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Weeding out functions for Ku

Jonathan B Weitzman

Author Affiliations

Genome Biology 2003, 4:spotlight-20030106-02  doi:10.1186/gb-spotlight-20030106-02


The electronic version of this article is the complete one and can be found online at:


Published:6 January 2003

© 2003 BioMed Central Ltd

Research news

The Ku70/80 heterodimer is essential for the non-homologous end-joining type of repair of DNA double-strand breaks and for telomere integrity. Inactivation of the KU70 gene in Arabidopsis results in telomere lengthening. In the Early Edition of the Proceedings of the National Academy of Sciences Karel Riha and Dorothy Shippen report that Ku70 is important for the maintenance of the telomeric C strand and is a negative regulator of telomerase (Proc Natl Acad Sci USA 2002, 10.1073/pnas.0236128100). They analysed plants lacking both KU70 and TERT (encoding the catalytic subunit of telomerase). The ku70/tert double mutants no longer exhibited the telomere elongation seen in ku70 single mutants. Double-mutants had accelerated telomere shortening, reflecting a defect in C-strand maintenance, and had proliferative defects, but there was no evidence for chromosome-end fusion events.

References

  1. DNA end-joining: from yeast to man.

    PubMed Abstract | Publisher Full Text OpenURL

  2. Telomere length deregulation and enhanced sensitivity to genotoxic stress in Arabidopsis mutants deficient in Ku70.

    PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  3. [http://www.pnas.org] webcite

    Proceedings of the National Academy of Sciences