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Probing the yeast proteome for RNA-processing factors

Sander Granneman1 and Susan J Baserga1,2,3*

Author Affiliations

1 Departments of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06520, USA

2 Genetics, Yale University School of Medicine, New Haven, CT 06520, USA

3 Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA

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Genome Biology 2003, 4:229 doi:10.1186/gb-2003-4-10-229

Published: 22 September 2003

Abstract

A method has been developed to identify proteins required for the biogenesis of non-coding RNA in yeast, using a microarray to screen for aberrant patterns of RNA processing in mutant strains, and new proteins involved in the processing of ribosomal and non-coding RNAs have been found.