Table 1 |
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|
Summary of the functional features of KRAB-containing zinc-finger repressor proteins |
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| Subfamily |
Protein |
Species |
Chromosomal localization |
Number of zinc fingers |
Expression pattern |
Proposed function |
|
|
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| A + B subfamily |
HKr18 |
Human |
19 |
20 |
Ubiquitous |
Repressor or RNA pol II |
| HKr19 |
Human |
7 |
11 |
Testis |
Cell differentiation |
|
| KID-1 |
Human |
5q35.3 |
13 |
Ubiquitous |
Nucleolar integrity |
|
| Kid2 |
Mouse |
11 |
13 |
Embryonic brain, kidney, gut and lung |
Mouse development |
|
| Kid3 |
Mouse |
11 |
11 |
Embryonic (E16.5) kidney, gut, lung and heart |
Kidney development |
|
| KOX1 |
Human |
12q24.33 |
9 |
Ubiquitous |
Repressor of RNA pol I, II, and II promoters |
|
| KRAZ1 |
Mouse |
17 |
15 |
Ubiquitous |
Repressor or RNA pol II |
|
| KRAZ2 |
Mouse |
5 |
9 |
Ubiquitous |
Repressor or RNA pol II |
|
| KS1 |
Rat |
10 |
Ubiquitous |
Tumor suppressor |
||
| KZF-1 |
Rat |
6 |
9 |
Testis |
Spermatogenesis |
|
| RbaK |
Human |
7 |
16 |
Ubiquitous |
Cell cycle arrest |
|
| RITA |
Human |
9q13 |
12 |
Ubiquitous |
Thyroid carcinoma |
|
| ZBRK1 |
Human |
19q13.41 |
8 |
Skeletal muscle |
Interaction with Brca1 |
|
| ZF5128 |
Human |
19 |
9 |
Ubiquitous |
T cell activation |
|
| ZNF41 |
Human |
Xp11.2 |
18 |
Ubiquitous |
Flanking a translocation breakpoint in synovial sarcoma |
|
| ZNF43 |
Human |
19p13.1-p12 |
22 |
T cell, B cell, and Ewing cells |
Differentiation and growth arrest in Ewing cells |
|
| ZNF85 |
Human |
19p13.1-p12 |
15 |
Ubiquitous |
Repressor RNA pol II |
|
| ZNF91 |
Human |
19p12 |
27 |
Seminoma and lymphoid cells |
Repression of the human Fc gamma RIIB gene |
|
| ZNF133 |
Human |
20p11.23 |
15 |
Ubiquitous |
Repressor RNA pol II |
|
| ZNF140 |
Human |
12q24 |
9 |
Lymphoid cells |
Repression of the human Fc gamma RIIB gene |
|
| ZNF141 |
Human |
4p16.3 |
10 |
Ubiquitous |
Candidate for the Wolf-Hirschhorn syndrome |
|
| ZNF157 |
Human |
Xp11.2 |
12 |
Blood vessels |
Potential hotspot for neurogenetic disorders |
|
| A subfamily |
HZF12 |
Human |
19 |
9 |
Ubiquitous |
Repressor of RNA pol II |
| MZF31 |
Mouse |
2 |
9 |
Ubiquitous |
Repressor of RNA pol II |
|
| pMLZ-8 |
Mouse |
4 |
15 |
Ubiquitous |
Repressor of RNA pol II |
|
| ZK1 |
Human |
19p13.2 |
15 |
Hematopoietic and various cancer cells |
Radiation-induced apoptotic cell death |
|
| ZNF136 |
Human |
19p13.1-p12 |
13 |
Ubiquitous |
Weak repressor of RNA pol II |
|
| A + b subfamily |
HZF4 |
Human |
19p13.32 |
18 |
Ubiquitous |
Repressor of RNA pol II |
| Zfp93 |
Human |
19p13.1-p12 |
15 |
Ubiquitous |
Repressor of RNA pol II |
|
| rKr2 |
Rat |
1 |
19 |
Central nervous system and testis |
Maturation of neurons and oligodendrocyte |
|
| ZNF45 |
Human |
19p13.2 |
11 |
Ubiquitous |
Potential hotspot for malignant disorders |
|
| ZNF155 |
Human |
19q13.2 |
11 |
Ubiquitous |
Repressor of RNA pol II |
|
| ZNF221 |
Human |
19q13.2 |
15 |
Ubiquitous |
Repressor of RNA pol II |
|
| ZNF222 |
Human |
19 |
7 |
Ubiquitous |
Repressor of RNA pol II |
|
| ZNF224 |
Human |
19 |
16 |
Ubiquitous |
Repressor of RNA pol II |
|
| ZNF225 |
Human |
19 |
17 |
Ubiquitous |
Repressor of RNA pol II |
|
| ZNF226 |
Human |
19 |
17 |
Ubiquitous |
Repressor of RNA pol II |
|
| SCAN subfamily |
FPM315 |
Human |
16p13.3 |
9 |
Ubiquitous |
Represses the Col11a2 promoter |
| SKAT2 |
Mouse |
11 |
14 |
Brain, kidney and hematopoietic cells |
Regulation of cytokine in T cells |
|
| Skz1 |
Mouse |
13 |
7 |
Ubiquitous |
Repressor of RNA pol II |
|
| ZFP95 |
Human |
7 |
13 |
Ubiquitous |
Repressor of RNA pol II |
|
| ZNF197 |
Human |
3p21. |
20 |
Ubiquitous |
Repressor of RNA pol II |
|
| ZNF202 |
Human |
11q23.3 |
8 |
Ubiquitous |
Energy metabolism |
|
| ZNF274 |
Human |
19q |
7 |
Ubiquitous |
Repressor of RNA pol II |
|
|
|
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|
Urrutia Genome Biology 2003 4:231 doi:10.1186/gb-2003-4-10-231 |
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