Human genes regulated in the diurnal comparison with orthologs that display circadian regulation in mouse heart and liver [19,20], and SCN . The 608 significantly regulated (p < 0.05) hSkM genes identified in the diurnal comparison (0800 and 2000 hours) were subjected to an additional statistical filter of absolute fold change > 20% (n = 239) and linked to mouse circadian-regulated orthologs. The resultant 44 putative hSkM circadian-regulated genes are represented as boxes and colored in GenMAPP  using different filtering criteria. (a) The 44 putative hSkM circadian-regulated genes colored by p values and displaying fold changes from the diurnal comparison (0800 vs 2000 hours non-exercised leg). (b) The 44 putative hSkM circadian-regulated genes colored by p values and displaying fold changes from the comparison 6 hours after RE. (c) The 44 putative hSkM circadian-regulated genes colored by p values and displaying fold changes from the 18 hours after RE comparison. Red, blue, and gray boxes indicate significant upregulation, downregulation, and no significant regulation, respectively, using p-value stringencies defined in the key for each comparison. Numbers to the right of the gene boxes are the fold changes in the diurnal comparison. L, promoter for the light-responsive element; E, E-box (Clock/Bmal1 promoter). Ortholog information is denoted to the left of the gene boxes: mHrts and mLvrs, mouse ortholog was circadian-regulated as described  in mouse heart or liver, respectively; mLvrp and mSCNp, mouse ortholog was diurnally regulated as described  in mouse liver or SCN, respectively.
Zambon et al. Genome Biology 2003 4:R61 doi:10.1186/gb-2003-4-10-r61