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An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targets

Karen I Zeller1, Anil G Jegga2, Bruce J Aronow2, Kathryn A O'Donnell3 and Chi V Dang1,3*

Author Affiliations

1 Division of Hematology, Department of Medicine, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

2 Divisions of Pediatric Informatics and Molecular Developmental Biology, Children's Hospital Research Foundation, Children's Hospital Medical Center and Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH 45229, USA

3 Program in Human Genetics and Molecular Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

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Genome Biology 2003, 4:R69 doi:10.1186/gb-2003-4-10-r69

Published: 11 September 2003

Abstract

We report a database of genes responsive to the Myc oncogenic transcription factor. The database Myc Target Gene prioritizes candidate target genes according to experimental evidence and clusters responsive genes into functional groups. We coupled the prioritization of target genes with phylogenetic sequence comparisons to predict c-Myc target binding sites, which are in turn validated by chromatin immunoprecipitation assays. This database is essential for the understanding of the genetic regulatory networks underlying the genesis of cancers.