Table 1

Myc-responsive genes reported in multiple systems

Gene target

LocusLink ID number

Description

Regulation

Myc DNA binding


APEX

328

Endonuclease

U

C*

CAD

790

Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase

U

C*

CCNA2

890

Cyclin A2

U

CCND2

894

CYCLIN D2

U

C*

CCNE1

898

CYCLIN E1

U

CDK4

1,019

CDK4 Cyclin-dependent kinase 4

U

G, C*

CDKN1A

1026

Cyclin-dependent kinase inhibitor 1A (p21, Cip1)

D

CDKN2B

1,030

Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

D

G,C

CHC1

1104

RCC1; chromosome condensation 1

U

G

DDX18

8,886

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 18 (Myc-regulated), MrDb

U

DUSP1

1,843

Dual specificity phosphatase 1

D

EIF4E

1,977

Eukaryotic translation initiation factor 4E

U

G, C*

ENO1

2,023

Enolase 1, (alpha)

U

C*

FASN

2,194

Fatty acid synthase

U

C*

FKBP4

2,288

FK506 binding protein 4, 59 kDa

U

FN1

2,335

Fibronectin 1

D

GADD45A

1,647

Growth arrest and DNA-damage-inducible, alpha

D

HSPA4

3,308

Heat shock 70 kDa protein 4

U

G

HSPCAL3

3,324

Heat shock 90 kDa protein 1, alpha-like 3

U

C*

HSPD1

3,329

Heat shock 60 kDa protein 1 (chaperonin)

U

C*

HSPE1

3,336

Heat shock 10 kDa protein 1 (chaperonin 10)

U

C*

LDHA

3,939

Lactate dehydrogenase A

U

G, C

MGST1

4,257

Glutathione transferase. GST-1

U

C*

MYC

4,609

v-myc myelocytomatosis viral oncogene homolog (avian)

D

NCL

4,691

Nucleolin

U

C*

NME1

4,830

Non-metastatic cells 1, protein (NM23A) expressed in

U

C*

NME2

4,831

NM23-H2, non-metastatic cells 2, protein (NM23B) expressed in

U

C

NPM1

4,869

Nucleophosmin, B23

U

C

ODC1

4,953

Ornithine decarboxylase 1

U

G, C

PPAT

5,471

Phosphoribosyl pyrophosphate amidotransferase

U

C*

PTMA

5,757

Prothymosin, alpha (gene sequence 28)

U

C*, D, G

RPL23

9,349

ribosomal protein L23

U

C*

RPL3

6,122

Ribosomal protein L3

U

RPL6

6,128

Ribosomal protein L6

U

RPS15A

6,210

Ribosomal protein S15A

U

SRM

6,723

Spermidine synthase

U

C*

TERT

7,015

Telomerase reverse transcriptase

U

G, C*

TFRC

7,037

Transferrin receptor (p90, CD71)

U

C*

THBS1

7,057

Thrombospondin 1

D

TNFSF6

356

Tumor necrosis factor (ligand) superfamily, member 6

U

G

TP53

7,157

Tumor protein p53 (Li-Fraumeni syndrome)

U

G

TPM1

7,168

Tropomyosin 1 (alpha)

D


U, upregulate; D, downregulated; G, gel shift; D, DNA footprint analysis; C, ChIP analysis; C*, ChIP [19]. Adapted from [1].

Zeller et al. Genome Biology 2003 4:R69   doi:10.1186/gb-2003-4-10-r69

Open Data