Table 1 |
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|
Myc-responsive genes reported in multiple systems |
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| Gene target |
LocusLink ID number |
Description |
Regulation |
Myc DNA binding |
|
|
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| APEX |
328 |
Endonuclease |
U |
C* |
| CAD |
790 |
Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase |
U |
C* |
| CCNA2 |
890 |
Cyclin A2 |
U |
|
| CCND2 |
894 |
CYCLIN D2 |
U |
C* |
| CCNE1 |
898 |
CYCLIN E1 |
U |
|
| CDK4 |
1,019 |
CDK4 Cyclin-dependent kinase 4 |
U |
G, C* |
| CDKN1A |
1026 |
Cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
D |
|
| CDKN2B |
1,030 |
Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) |
D |
G,C |
| CHC1 |
1104 |
RCC1; chromosome condensation 1 |
U |
G |
| DDX18 |
8,886 |
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 18 (Myc-regulated), MrDb |
U |
|
| DUSP1 |
1,843 |
Dual specificity phosphatase 1 |
D |
|
| EIF4E |
1,977 |
Eukaryotic translation initiation factor 4E |
U |
G, C* |
| ENO1 |
2,023 |
Enolase 1, (alpha) |
U |
C* |
| FASN |
2,194 |
Fatty acid synthase |
U |
C* |
| FKBP4 |
2,288 |
FK506 binding protein 4, 59 kDa |
U |
|
| FN1 |
2,335 |
Fibronectin 1 |
D |
|
| GADD45A |
1,647 |
Growth arrest and DNA-damage-inducible, alpha |
D |
|
| HSPA4 |
3,308 |
Heat shock 70 kDa protein 4 |
U |
G |
| HSPCAL3 |
3,324 |
Heat shock 90 kDa protein 1, alpha-like 3 |
U |
C* |
| HSPD1 |
3,329 |
Heat shock 60 kDa protein 1 (chaperonin) |
U |
C* |
| HSPE1 |
3,336 |
Heat shock 10 kDa protein 1 (chaperonin 10) |
U |
C* |
| LDHA |
3,939 |
Lactate dehydrogenase A |
U |
G, C |
| MGST1 |
4,257 |
Glutathione transferase. GST-1 |
U |
C* |
| MYC |
4,609 |
v-myc myelocytomatosis viral oncogene homolog (avian) |
D |
|
| NCL |
4,691 |
Nucleolin |
U |
C* |
| NME1 |
4,830 |
Non-metastatic cells 1, protein (NM23A) expressed in |
U |
C* |
| NME2 |
4,831 |
NM23-H2, non-metastatic cells 2, protein (NM23B) expressed in |
U |
C |
| NPM1 |
4,869 |
Nucleophosmin, B23 |
U |
C |
| ODC1 |
4,953 |
Ornithine decarboxylase 1 |
U |
G, C |
| PPAT |
5,471 |
Phosphoribosyl pyrophosphate amidotransferase |
U |
C* |
| PTMA |
5,757 |
Prothymosin, alpha (gene sequence 28) |
U |
C*, D, G |
| RPL23 |
9,349 |
ribosomal protein L23 |
U |
C* |
| RPL3 |
6,122 |
Ribosomal protein L3 |
U |
|
| RPL6 |
6,128 |
Ribosomal protein L6 |
U |
|
| RPS15A |
6,210 |
Ribosomal protein S15A |
U |
|
| SRM |
6,723 |
Spermidine synthase |
U |
C* |
| TERT |
7,015 |
Telomerase reverse transcriptase |
U |
G, C* |
| TFRC |
7,037 |
Transferrin receptor (p90, CD71) |
U |
C* |
| THBS1 |
7,057 |
Thrombospondin 1 |
D |
|
| TNFSF6 |
356 |
Tumor necrosis factor (ligand) superfamily, member 6 |
U |
G |
| TP53 |
7,157 |
Tumor protein p53 (Li-Fraumeni syndrome) |
U |
G |
| TPM1 |
7,168 |
Tropomyosin 1 (alpha) |
D |
|
|
|
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|
U, upregulate; D, downregulated; G, gel shift; D, DNA footprint analysis; C, ChIP analysis; C*, ChIP [19]. Adapted from [1]. |
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|
Zeller et al. Genome Biology 2003 4:R69 doi:10.1186/gb-2003-4-10-r69 |
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