Table 1 |
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|
The septin genes and proteins in five representative organisms |
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|
Species |
Approved gene name |
Chromosomal location* |
Size (amino acids) |
Mass (kDa) |
Isoelectric point (pI) |
Charge |
Number of predicted coiled coils |
Accession number |
|
|
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|
Saccharomyces cerevisiae |
Cdc3 |
XII:764137 |
520 |
60.0 |
5.3 |
A |
2 |
L16548 |
|
Cdc10 |
III:118342 |
322 |
37.0 |
5.6 |
A |
0 |
L16549 |
|
|
Cdc11 |
X:576294 |
415 |
47.6 |
4.8 |
A |
1 |
L16550 |
|
|
Cdc12 |
VIII:328038 |
407 |
46.7 |
8.2 |
B |
1 |
L16551 |
|
|
Spr3 |
VII:607564 |
512 |
59.8 |
7.3 |
N |
3 |
U24129 |
|
|
Spr28 |
IV:905043 |
423 |
48.2 |
5.8 |
A |
1 |
NP_010504 |
|
|
Shs1/Sep7 |
IV:52446 |
551 |
62.6 |
5.3 |
A |
2 |
Z74273 |
|
|
Schizosaccharomyces pombe |
spn1 |
I:1067997 |
469 |
53.7 |
5.3 |
A |
1 |
U31742 |
|
spn2 |
I:960487 |
331 |
38.1 |
8.0 |
B |
0 |
U29888 |
|
|
spn3 |
II:2682372 |
412 |
46.6 |
4.7 |
A |
1 |
U29889 |
|
|
spn4 |
I:1962024 |
380 |
44.7 |
7.0 |
N |
1 |
U29890 |
|
|
spn5 |
I:3044705 |
464 |
53.1 |
8.2 |
B |
1 |
U29891 |
|
|
spn6 |
III:421493 |
380 |
44.0 |
6.9 |
N |
1 |
AL032824 |
|
|
spn7 |
II:161221 |
428 |
49.2 |
5.2 |
A |
0 |
AF417166 |
|
|
Caenorhabditis elegans |
unc-59 |
I:21.15 |
459 |
52.9 |
8.9 |
B |
1 |
NM_060987 |
|
unc-61 |
V:6.66 |
530 |
60.7 |
8.9 |
B |
1 |
NM_182356 |
|
|
Drosophila melanogaster |
Pnut |
44C2 |
539 |
60.2 |
9.0 |
B |
1 |
NM_165597 |
|
Sep1 |
19F5 |
361 |
41.1 |
6.1 |
A |
2 |
NM_167747 |
|
|
Sep2 |
92F2 |
419 |
48.5 |
7.4 |
N |
1 |
NM_079693 |
|
|
Sep4 |
15A1 |
427 |
49.0 |
6.9 |
N |
2 |
NM_167530 |
|
|
Sep5 |
43F8 |
422 |
48.5 |
7.3 |
N |
1 |
NM_165578 |
|
|
Homo sapiens |
Sept1 |
16p11.1 |
366 |
41.8 |
5.5 |
A |
2 |
NM_052838 |
|
Sept2 |
2q37.3 |
361 |
41.5 |
6.2 |
A |
2 |
NM_004404 |
|
|
Sept3 |
22q13.2 |
345 |
39.3 |
6.8 |
N |
0 |
NM_145733 |
|
|
Sept4 |
17q23 |
478 |
55.1 |
5.7 |
A |
2 |
NM_004574 |
|
|
Sept5 |
22q11.2 |
369 |
42.3 |
6.4 |
A |
2 |
NM_002688 |
|
|
Sept6 |
Xq24 |
427 |
48.9 |
6.4 |
A |
1 |
NM_145799 |
|
|
Sept7 |
7q36.1 |
418 |
48.8 |
9.0 |
B |
1 |
NM_001788 |
|
|
Sept8 |
5q31 |
483 |
55.8 |
5.9 |
A |
1 |
XM_034872 |
|
|
Sept9 |
17q25.3 |
586 |
65.4 |
9.3 |
B |
0 |
AF189713 |
|
|
Sept10 |
8q11.23 |
517 |
60.0 |
6.6 |
N |
1 |
BC020502 |
|
|
Sept11 |
4q21.22 |
429 |
49.4 |
6.4 |
A |
1 |
NM_018243 |
|
|
Sept12 |
16p13.3 |
358 |
40.8 |
6.7 |
N |
0 |
NM_144605 |
|
|
|
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|
The data refer to the largest gene products for each gene, deduced from cDNAs on the sequence databases. *The numbers given for the yeast genes refer to the position of the gene along the sequence of the chromosome. A, acidic (pI < 6.5); B, basic (pI > 7.5); N, neutral. The algorithm COILS [56,57] was used to predict coiled coils, and the peaks above an arbitrary threshold (p > 0.8 at a window size of 14) were counted. The mouse genome has counterparts to each of the 12 human septin genes (not shown). For comparative nomenclature of the mouse and human Sept1-Sept10 genes and the products, see [58]. |
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Kinoshita Genome Biology 2003 4:236 doi:10.1186/gb-2003-4-11-236 |
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