Genome Biology
Volume 4
Issue 12 |
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OpinionMulti-species sequence comparison: the next frontier in genome annotationInna Dubchak1  and Kelly Frazer2 1Genomics Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA 2Perlegen Sciences, 2021 Stierlin Ct., Mountain View, CA 94043, USA  author email corresponding author email
Genome Biology 2003,
4:122doi:10.1186/gb-2003-4-12-122
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| Published: |
27 November 2003 |
Subject areas: Evolution, Bioinformatics, Genome studies Abstract
Multi-species comparisons of DNA sequences are more powerful for discovering functional sequences than pairwise DNA sequence comparisons. Most current computational tools have been designed for pairwise comparisons, and efficient extension of these tools to multiple species will require knowledge of the ideal evolutionary distance to choose and the development of new algorithms for alignment, analysis of conservation, and visualization of results. | 
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