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Opinion

Multi-species sequence comparison: the next frontier in genome annotation

Inna Dubchak1* and Kelly Frazer2

Author Affiliations

1 Genomics Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA

2 Perlegen Sciences, 2021 Stierlin Ct., Mountain View, CA 94043, USA

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Genome Biology 2003, 4:122  doi:10.1186/gb-2003-4-12-122

Published: 27 November 2003

Abstract

Multi-species comparisons of DNA sequences are more powerful for discovering functional sequences than pairwise DNA sequence comparisons. Most current computational tools have been designed for pairwise comparisons, and efficient extension of these tools to multiple species will require knowledge of the ideal evolutionary distance to choose and the development of new algorithms for alignment, analysis of conservation, and visualization of results.