Genome Biology
Volume 4
Issue 12 |
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MinireviewGenetics and functional genomics of type 2 diabetes mellitusAyo Toye and Dominique Gauguier  The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK  author email corresponding author email
Genome Biology 2003,
4:241doi:10.1186/gb-2003-4-12-241
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24 November 2003 |
Subject areas: Medicine, Genome studies, Physiology Abstract
Genome-wide studies of transcription in the skeletal muscle of type 2 diabetic patients have identified coordinated changes in the expression of genes involved in oxidative phosphorylation, and have underlined the central role of the oxidative-phosphorylation regulator, PCG1α. These findings help unravel the complex pathogenesis and inheritance of polygenic type 2 diabetes mellitus. | 
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