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Opinion

Exploiting microarrays to reveal differential gene expression in the nervous system

Robert S Griffin, Charles D Mills, Michael Costigan and Clifford J Woolf*

Author Affiliations

Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA

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Genome Biology 2003, 4:105  doi:10.1186/gb-2003-4-2-105

Published: 29 January 2003

Abstract

Microarrays have been used in a wide variety of experimental systems, but realizing their full potential is contingent on sophisticated and rigorous experimental design and data analysis. This article highlights what is needed to get the most out of microarrays in terms of accurately and effectively revealing differential gene expression and regulation in the nervous system.