DNA replication: telling time with microarrays
1 Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
2 Cancer Research UK Chromosome Replication Group, Division of Gene Regulation and Expression, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
Genome Biology 2003, 4:204 doi:10.1186/gb-2003-4-2-204Published: 30 January 2003
A long-standing hypothesis about eukaryotic DNA replication is that the late-replicating regions are transcriptionally inert and that repressing transcription delays replication initiation. But do contrasting results from yeast and a recent study in Drosophila imply that replication timing and transcriptional activity are differentially regulated in yeast and higher eukaryotes?