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DNA replication: telling time with microarrays

Heather J McCune1 and Anne D Donaldson2*

Author Affiliations

1 Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA

2 Cancer Research UK Chromosome Replication Group, Division of Gene Regulation and Expression, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK

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Genome Biology 2003, 4:204  doi:10.1186/gb-2003-4-2-204

Published: 30 January 2003

Abstract

A long-standing hypothesis about eukaryotic DNA replication is that the late-replicating regions are transcriptionally inert and that repressing transcription delays replication initiation. But do contrasting results from yeast and a recent study in Drosophila imply that replication timing and transcriptional activity are differentially regulated in yeast and higher eukaryotes?