Genome Biology
Volume 4
Issue 2 |
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MinireviewDNA replication: telling time with microarraysHeather J McCune1 and Anne D Donaldson2  1Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA 2Cancer Research UK Chromosome Replication Group, Division of Gene Regulation and Expression, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK  author email corresponding author email
Genome Biology 2003,
4:204doi:10.1186/gb-2003-4-2-204
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| Published: |
30 January 2003 |
Subject areas: Molecular biology, Cell biology, Genome studies Abstract
A long-standing hypothesis about eukaryotic DNA replication is that the late-replicating regions are transcriptionally inert and that repressing transcription delays replication initiation. But do contrasting results from yeast and a recent study in Drosophila imply that replication timing and transcriptional activity are differentially regulated in yeast and higher eukaryotes? | 
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