Table 1

Summary of the functional features of Sp1-like/KLF family members
Protein*
 KLF number
 Species
 Chromosomal localization†
 Transcriptional activity (and functional domains)
 Expression pattern
 Interacting coactivatorand/or corepressor
 Cellular functions
Sp1
 -
 Human, mouse, rat and Drosophila
 12q13
 Activator (Q-rich domains)
 Ubiquitous
 CRSP, p300/CBP, TAFII130
 Embryogenesis
Sp2
 -
 Human, mouse and rat
 17q21
 Unknown (Q-rich domain)
Unknown
 Unknown
Sp3
 -
 Human, mouse and rat
 2q31
 Activator and/or repressor (Q-rich domains)
 Ubiquitous
 Unknown
 Unknown
Sp4
 -
 Human, mouse and rat
 7p15
 Activator (Q-rich domains)
 Brain-enriched
 Unknown
 Post-natal survival and male fertility
mSp5
 -
 Mouse
Unknown
 Ubiquitous
 Unknown
 Unknown
Sp6
 KLF14
 Human and mouse
 17q21
 Activator
 Ubiquitous
 Unknown
 Unknown
EKLF
 KLF1
 Human and mouse
 19p13
 Activator (acidic domain)
 Erythroid and mast cells
 p300/CBP, PCAF, SWI/SNF and mSin3A
 Erythropoiesis
LKLF
 KLF2
 Human and mouse
 19p13
 Activator (acidic domain)
 Lung, blood vessels, lymphocytes
 Unknown
 Blood vessel, lung development, T-cell survival
BKLF
 KLF3
 Human, mouse and rat
 4p14
 Activator/repressor (PVDLS/T motif)
 Erythroid tissue- and brain-enriched
 CtBP2
 Unknown
GKLF
 KLF4
 Human, mouse, rat and zebrafish
 9q31
 Activator and/or repressor (acidic domain)
 Gut-enriched
 p300/CBP
 Anti-proliferation, survival
IKLF
 KLF5
 Human, mouse and rat
 13q21
 Activator
 Gut and epithelial tissues
 Unknown
 Cell growth
CPBP
 KLF6
 Human and mouse
 10p15
 Activator
 Ubiquitous
 Unknown
 Putative tumor suppressor
UKLF
 KLF7
 Human and mouse
 2q32
 Activator (acidic domain)
 Ubiquitous
 Unknown
 Cell-cycle arrest
BKLF3
 KLF8
 Human
 Xp11
 Repressor (PVDLS/T motif)
 Ubiquitous
 CtBP2
 Unknown
BTEB1
 KLF9
 Human, mouse and rat
 9q13
 Activator/repressor (SID)
 Ubiquitous
 mSin3A
 Neurite outgrowth and carcinogen metabolism
TIEG1
 KLF10
 Human
 8q22
 Repressor (SID, R2, R3)
 Ubiquitous
 mSin3A
 Apoptosis, anti-proliferation
TIEG2/FKLF
 KLF11
 Human
 2p25
 Activator and/or repressor (SID, R2, R3)
 Ubiquitous
 mSin3A
 Anti-proliferation
AP-2rep
 KLF12
 Human, mouse, rat and zebrafish
 13q21
 Repressor (PVDLS/T motif)
 Brain, kidney, liver and lung
 CtBP1
 Unknown
BTEB3/RFLAT-1/FKLF-2
 KLF13
 Human, mouse and rat
 15q12
 Activator/repressor (SID, R2 and R3)
 Ubiquitous
 mSin3A, p300/CBP and PCAF
 Anti-proliferation and carcinogen metabolism
KKLF
 KLF15
 Human, mouse and rat
 3q13
 Repressor
 Ubiquitous
 Unknown
 Unknown
BTEB4/mDRRF
 KLF16
 Human and mouse
 19q13
 Repressor (SID)
 Ubiquitous
 mSin3A
 Carcinogen metabolism
BTEB5
 -
 Human
 7
 Unknown
 Unknown
 Unknown
 Unknown

*Original name with which the protein was first published. †Chromosomal localization data refer to the human genes and have been obtained from the human genome database of the National Center for Biotechnology Information (NCBI) [57].

Kaczynski et al. Genome Biology 2003 4:206   doi:10.1186/gb-2003-4-2-206