Table 3

Meiosis-specific S. cerevisiae genes with orthologs in C. glabrata

Gene

Function

IME1

Master regulatory switch of meiosis

MCK1

Kinase required for maximal IME1 expression

RIM9

Stimulates expression of IME1

IME2

Kinase, stimulates meiotic gene expression

UME6

Transcriptional regulator of meiotic genes

RIM4

Activation of sporulation-specific genes

IDS2

Ime2-dependent signaling protein

MUM2

Required for premeiotic DNA synthesis and sporulation

HOP2

Prevents nonhomologous synapsis in meiosis

MSH4

Meiosis-specific MutS homolog, recombination

SPO1

Required for spindle body duplication

SPO22

Required for meiotic chromosome segregation

CSM1

Required for meiotic chromosome segregation

CSM3

Required for meiotic chromosome segregation

SMK1

Sporulation-specific MAP kinase

DIT1

Dityrosine biosynthesis enzyme

SPO75

Required for spore and ascus formation

SMA2

Required for proper prospore membrane formation

SPS2*

Putative prospore membrane protein

*We are not certain whether plasmid CG4206 contains an ortholog of SPS2 or the similar gene YCL048W, but we have included it in the table because both SPS2 and YCL048W encode prospore membrane proteins induced during sporulation [70].

Wong et al. Genome Biology 2003 4:R10   doi:10.1186/gb-2003-4-2-r10