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Interleukins in inflammation

Jonathan Weitzman

Author Affiliations

Genome Biology 2003, 4:spotlight-20030217-01  doi:10.1186/gb-spotlight-20030217-01

The electronic version of this article is the complete one and can be found online at:


Published:17 February 2003

© 2003 BioMed Central Ltd

Research news

Figuring out the roles of individual cytokines can be complicated by the fact that they may share common functional subunits. Interleukin-12 (IL-12) is a heterodimer of p35 and p40 subunits, and is thought to play a key role in T-cell-dependent immunity and inflammation. In the February 13 Nature Cua et al. report that IL-23, a heterodimer of the IL-12 p40 subunit together with a distinct p19 subunit, is perhaps a more important factor in autoimmune inflammation (Nature 2003, 421:744-748). They used knockout mice, and cytokine replacement studies, to address the role of the p19, p35 or p40 subunits in experimental autoimmune encephalomyelitis (EAE), an inflammatory disease model. IL-23, but not IL-12, was essential for the development of EAE. IL-23 appears to directly activate macrophages in vivo, thereby inducing cytokine expression and late-stage inflammation.

References

  1. Interleukin-12 and the regulation of innate resistance and adaptive immunity.

    PubMed Abstract | Publisher Full Text OpenURL

  2. [http://www.nature.com] webcite

    Nature