Genome Biology
Volume 4
Issue 4 |
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MinireviewModifications of histone cores and tails in V(D)J recombinationKathrin Muegge  Laboratory of Molecular Immunoregulation, SAIC-Basic Science Program, National Cancer Institute, Frederick, MD 21701, USA  author email corresponding author email
Genome Biology 2003,
4:211doi:10.1186/gb-2003-4-4-211
Subject areas: Molecular biology, Immunology, Genetics Abstract
The organization of chromatin and modifications to the tails of histone proteins are thought to be important in regulating the rearrangement of V, D and J gene segments, which encode immunoglobulins and T-cell receptors. A recent study shows that methylated lysine 79 in the core region of histone H3 also plays a role by providing a euchromatic 'mark' that may regulate access of the V(D)J recombinase. | 
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