Table 1 |
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Features of human protein prenyltransferases |
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| Farnesyltransferase (FT) |
Geranylgeranyltransferase I (GGT1) |
Geranylgeranyltransferase II (GGT2 or RabGGT) |
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| Gene name (α subunit) |
FNTA |
FNTA |
RABGGTA |
| Gene name (β subunit) |
FNTB |
PGGT1B |
RABGGTB |
| Substrate motif |
Carboxy-terminal -Ca1a2X box* |
Carboxy-terminal -Ca1a2X box* |
Carboxy-terminal motif such as -CC, -CXC, -CCX, -CCXX, -CCXXX, or -CXXX† |
| Lipid anchor |
 Farnesyl |
 Geranylgeranyl |
 Geranylgeranyl(one or two moieties per substrate) |
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*C, cysteine; a1, and a2 are amino acids that are preferably aliphatic; the identity of a1 is more flexible than a2. X can be C, S, Q, A, M, T, H, V, N, F, G, or I for FT, or L, F, I, V, or M for GGT1 (in decreasing order of affinity). †Requires an escort protein such as REP1. |
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Maurer-Stroh et al. Genome Biology 2003 4:212 doi:10.1186/gb-2003-4-4-212 |
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