Table 2

The 428 human ePKs with known or likely kinase catalytic function

Group

Number within group

Family

Number within family

Family members (SUGEN nomenclature)


TK

84

Ack

2

ACK, TNK1

Abl

2

ABL, ARG

Csk

2

CSK, CTK

FAK

2

FAK, PYK2

Fer

2

FER, FES

JAK

4

JAK1, JAK2, JAK3, TYK2

Src

11

BLK, BRK, FGR, FRK, FYN, HCK, LCK, LYN, SRC, SRM, YES

Syk

2

SYK, ZAP70

Tec

5

BMX, BTK, ITK, TEC, TXK

Alk

2

ALK, LTK

Axl

3

AXL, MER, TYRO3

DDR

2

DDR1, DDR2

EGFR

3

EGFR, HER2/ErbB2, HER4/ErbB4

Eph

12

EphA1, EphA2, EphA3, EphA4, EphA5, EphA6, EphA7, EphA8, EphB1, EphB2, EphB3, EphB4

FGFR

4

FGFR1, FGFR2, FGFR3, FGFR4

InsR

3

IGF1R, INSR, IRR

Lmr

3

LMR1, LMR2, LMR3

Met

2

MET, RON

Musk

1

MUSK

PDGFR/VEGFR

8

FLT3, FMS, KIT, PDGFRa, PDGFRb, FLT1, FLT4, KDR

Ret

1

RET

Ror

2

ROR1, ROR2

Sev

1

ROS

Tie

2

TIE1, TIE2

Trk

3

TRKA, TRKB, TRKC

AGC

61

PKA

5

PKACa, PKACb, PKACg, PRKX, PRKY

PKG

2

PKG1, PKG2

PKC

9

PKCa, PKCb, PKCd, PKCe, PKCg, PKCh, PKCi, PKCt, PKCz

AKT

3

AKT1, AKT2, AKT3

DMPK

7

CRIK, DMPK1, DMPK2, MRCKa, MRCKb, ROCK1, ROCK2

GRK

7

BARK1, BARK2, GPRK4, GPRK5, GPRK6, GPRK7, RHOK

MAST

5

MAST1, MAST2, MAST3, MAST4, MASTL

NDR

4

LATS1, LATS2, NDR1, NDR2

PKB

1

PDK1

PKN

3

PKN1, PKN2, PKN3

RSK

9

MSK1, MSK2, RSK1, RSK2, RSK3, RSK4, SgK494, p70S6K, p70S6Kb

SGK

3

SGK, SGK2, SGK3

YANK

3

YANK1, YANK2, YANK3

CAMK

66

CAMK1

5

CaMK1a, CaMK1b, CaMK1d, CaMK1g, CaMK4

CAMK2

4

CaMK2a, CaMK2b, CaMK2d, CaMK2g

CAMKL

20

AMPKa1, AMPKa2, BRSK1, BRSK2, CHK1, HUNK, LKB1, MARK1, MARK2, MARK3, MARK4, MEL, NIM1, NuaK1, NuaK2, PASK, QIK, QSK, SIK, SNRK

DAPK

5

DAPK1, DAPK2, DAPK3, DRAK1, DRAK2

DCAMKL

3

DCAMKL1, DCAMKL2, DCAMKL3

MAPKAPK

5

MAPKAPK2, MAPKAPK3, MAPKAPK5, MNK1, MNK2

MLCK

4

caMLCK, skMLCK, smMLCK, SgK085

PHK

2

PHKg1, PHKg2

PIM

3

PIM1, PIM2, PIM3

PKD

3

PKD1, PKD2, PKD3

PSK

1

PSKH1

RAD53

1

CHK2

Trio

4

Obscn, SPEG, Trad, Trio

TSSK

5

SSTK, TSSK1, TSSK2, TSSK3, TSSK

CAMK-Unique

1

STK33

CMGC

61

CDK

20

CCRK, CDC2, CDK2, CDK3, CDK4, CDK5, CDK6, CDK7, CDK8, CDK9, CDK10, CDK11, CHED, CRK7, PCTAIRE1, PCTAIRE2, PCTAIRE3, PFTAIRE1, PFTAIRE2, PITSLRE

MAPK

14

Erk1, Erk2, Erk3, Erk4, Erk5, Erk7, JNK1, JNK2, JNK3, NLK, p38a, p38b, p38d, p38g

GSK

2

GSK3A, GSK3B

CLK

4

CLK1, CLK2, CLK3, CLK4

CDKL

5

CDKL1, CDKL2, CDKL3, CDKL4, CDKL5

DYRK

10

DYRK1A, DYRK1B, DYRK2, DYRK3, DYRK4, HIPK1, HIPK2, HIPK3, HIPK4, PRP4

RCK

3

ICK, MAK, MOK

SRPK

3

MSSK1, SRPK1, SRPK2

STE

45

STE7

7

MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7

STE20

28

GCK, HPK1, KHS1, KHS2, LOK, MST1, MST2, MST3, MST4, MYO3A, MYO3B, OSR1, PAK1, PAK2, PAK3, PAK4, PAK5, PAK6, SLK, STLK3, TAO1, TAO2, TAO3, YSK1, ZC1/HGK, ZC2/TNIK, ZC3/MINK, ZC4/NRK

STE11

8

MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8

STE-Unique

2

COT, NIK

TKL

37

IRAK

2

IRAK1, IRAK4

LISK

4

LIMK1, LIMK2, TESK1, TESK2

LRRK

2

LRRK1, LRRK2

MLK

9

DLK, HH498, LZK, MLK1, MLK2, MLK3, MLK4, TAK1, ZAK

RAF

3

ARAF, BRAF, RAF1

RIPK

5

ANKRD3, RIPK1, RIPK2, RIPK3, SgK288

STKR

12

ACTR2, ACTR2B, ALK1, ALK2, ALK4, ALK7, BMPR1A, BMPR1B, BMPR2, MISR2, TGFbR1, TGFbR2

CK1

11

CK1

7

CK1a, CK1a2, CK1d, CK1e, CK1g1, CK1g2, CK1g3

TTBK

2

TTBK1, TTBK2

VRK

2

VRK1, VRK2

Other

63

Aur

3

AurA, AurB, AurC

BUB

1

BUB1

Bud32

1

PRPK

CAMKK

2

CaMKK1, CaMKK2

CDC7

1

CDC7

CK2

2

CK2a1, CK2a2

IKK

4

IKKa, IKKb, IKKe, TBK1

IRE

2

IRE1, IRE2

MOS

1

MOS

NAK

4

AAK1, BIKE, GAK, MPSK1

NEK

11

NEK1, NEK2, NEK3, NEK4, NEK5, NEK6, NEK7, NEK8, NEK9, NEK10, NEK11

NKF1

3

SBK, SgK069, SgK110

NKF2

1

PINK1

NKF4

2

CLIK1, CLIK1L

PEK

4

GCN2, HRI, PEK, PKR

PLK

4

PLK1, PLK2, PLK3, PLK4

TLK

2

TLK1, TLK2

TOPK

1

PBK

TTK

1

TTK

ULK

4

Fused, ULK1, ULK2, ULK3

VPS15

1

PIK3R4

WEE

3

MYT1, Wee1, Wee1B

Wnk

4

Wnk1, Wnk2, Wnk3, Wnk4

Other-Unique

2

KIS, SgK496


Hanks Genome Biology 2003 4:111   doi:10.1186/gb-2003-4-5-111