|
The 428 human ePKs with known or likely kinase catalytic function |
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| Group |
Number within group |
Family |
Number within family |
Family members (SUGEN nomenclature) |
|
|
||||
| TK |
84 |
Ack |
2 |
ACK, TNK1 |
| Abl |
2 |
ABL, ARG |
||
| Csk |
2 |
CSK, CTK |
||
| FAK |
2 |
FAK, PYK2 |
||
| Fer |
2 |
FER, FES |
||
| JAK |
4 |
JAK1, JAK2, JAK3, TYK2 |
||
| Src |
11 |
BLK, BRK, FGR, FRK, FYN, HCK, LCK, LYN, SRC, SRM, YES |
||
| Syk |
2 |
SYK, ZAP70 |
||
| Tec |
5 |
BMX, BTK, ITK, TEC, TXK |
||
| Alk |
2 |
ALK, LTK |
||
| Axl |
3 |
AXL, MER, TYRO3 |
||
| DDR |
2 |
DDR1, DDR2 |
||
| EGFR |
3 |
EGFR, HER2/ErbB2, HER4/ErbB4 |
||
| Eph |
12 |
EphA1, EphA2, EphA3, EphA4, EphA5, EphA6, EphA7, EphA8, EphB1, EphB2, EphB3, EphB4 |
||
| FGFR |
4 |
FGFR1, FGFR2, FGFR3, FGFR4 |
||
| InsR |
3 |
IGF1R, INSR, IRR |
||
| Lmr |
3 |
LMR1, LMR2, LMR3 |
||
| Met |
2 |
MET, RON |
||
| Musk |
1 |
MUSK |
||
| PDGFR/VEGFR |
8 |
FLT3, FMS, KIT, PDGFRa, PDGFRb, FLT1, FLT4, KDR |
||
| Ret |
1 |
RET |
||
| Ror |
2 |
ROR1, ROR2 |
||
| Sev |
1 |
ROS |
||
| Tie |
2 |
TIE1, TIE2 |
||
| Trk |
3 |
TRKA, TRKB, TRKC |
||
| AGC |
61 |
PKA |
5 |
PKACa, PKACb, PKACg, PRKX, PRKY |
| PKG |
2 |
PKG1, PKG2 |
||
| PKC |
9 |
PKCa, PKCb, PKCd, PKCe, PKCg, PKCh, PKCi, PKCt, PKCz |
||
| AKT |
3 |
AKT1, AKT2, AKT3 |
||
| DMPK |
7 |
CRIK, DMPK1, DMPK2, MRCKa, MRCKb, ROCK1, ROCK2 |
||
| GRK |
7 |
BARK1, BARK2, GPRK4, GPRK5, GPRK6, GPRK7, RHOK |
||
| MAST |
5 |
MAST1, MAST2, MAST3, MAST4, MASTL |
||
| NDR |
4 |
LATS1, LATS2, NDR1, NDR2 |
||
| PKB |
1 |
PDK1 |
||
| PKN |
3 |
PKN1, PKN2, PKN3 |
||
| RSK |
9 |
MSK1, MSK2, RSK1, RSK2, RSK3, RSK4, SgK494, p70S6K, p70S6Kb |
||
| SGK |
3 |
SGK, SGK2, SGK3 |
||
| YANK |
3 |
YANK1, YANK2, YANK3 |
||
| CAMK |
66 |
CAMK1 |
5 |
CaMK1a, CaMK1b, CaMK1d, CaMK1g, CaMK4 |
| CAMK2 |
4 |
CaMK2a, CaMK2b, CaMK2d, CaMK2g |
||
| CAMKL |
20 |
AMPKa1, AMPKa2, BRSK1, BRSK2, CHK1, HUNK, LKB1, MARK1, MARK2, MARK3, MARK4, MEL, NIM1, NuaK1, NuaK2, PASK, QIK, QSK, SIK, SNRK |
||
| DAPK |
5 |
DAPK1, DAPK2, DAPK3, DRAK1, DRAK2 |
||
| DCAMKL |
3 |
DCAMKL1, DCAMKL2, DCAMKL3 |
||
| MAPKAPK |
5 |
MAPKAPK2, MAPKAPK3, MAPKAPK5, MNK1, MNK2 |
||
| MLCK |
4 |
caMLCK, skMLCK, smMLCK, SgK085 |
||
| PHK |
2 |
PHKg1, PHKg2 |
||
| PIM |
3 |
PIM1, PIM2, PIM3 |
||
| PKD |
3 |
PKD1, PKD2, PKD3 |
||
| PSK |
1 |
PSKH1 |
||
| RAD53 |
1 |
CHK2 |
||
| Trio |
4 |
Obscn, SPEG, Trad, Trio |
||
| TSSK |
5 |
SSTK, TSSK1, TSSK2, TSSK3, TSSK |
||
| CAMK-Unique |
1 |
STK33 |
||
| CMGC |
61 |
CDK |
20 |
CCRK, CDC2, CDK2, CDK3, CDK4, CDK5, CDK6, CDK7, CDK8, CDK9, CDK10, CDK11, CHED, CRK7, PCTAIRE1, PCTAIRE2, PCTAIRE3, PFTAIRE1, PFTAIRE2, PITSLRE |
| MAPK |
14 |
Erk1, Erk2, Erk3, Erk4, Erk5, Erk7, JNK1, JNK2, JNK3, NLK, p38a, p38b, p38d, p38g |
||
| GSK |
2 |
GSK3A, GSK3B |
||
| CLK |
4 |
CLK1, CLK2, CLK3, CLK4 |
||
| CDKL |
5 |
CDKL1, CDKL2, CDKL3, CDKL4, CDKL5 |
||
| DYRK |
10 |
DYRK1A, DYRK1B, DYRK2, DYRK3, DYRK4, HIPK1, HIPK2, HIPK3, HIPK4, PRP4 |
||
| RCK |
3 |
ICK, MAK, MOK |
||
| SRPK |
3 |
MSSK1, SRPK1, SRPK2 |
||
| STE |
45 |
STE7 |
7 |
MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7 |
| STE20 |
28 |
GCK, HPK1, KHS1, KHS2, LOK, MST1, MST2, MST3, MST4, MYO3A, MYO3B, OSR1, PAK1, PAK2, PAK3, PAK4, PAK5, PAK6, SLK, STLK3, TAO1, TAO2, TAO3, YSK1, ZC1/HGK, ZC2/TNIK, ZC3/MINK, ZC4/NRK |
||
| STE11 |
8 |
MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8 |
||
| STE-Unique |
2 |
COT, NIK |
||
| TKL |
37 |
IRAK |
2 |
IRAK1, IRAK4 |
| LISK |
4 |
LIMK1, LIMK2, TESK1, TESK2 |
||
| LRRK |
2 |
LRRK1, LRRK2 |
||
| MLK |
9 |
DLK, HH498, LZK, MLK1, MLK2, MLK3, MLK4, TAK1, ZAK |
||
| RAF |
3 |
ARAF, BRAF, RAF1 |
||
| RIPK |
5 |
ANKRD3, RIPK1, RIPK2, RIPK3, SgK288 |
||
| STKR |
12 |
ACTR2, ACTR2B, ALK1, ALK2, ALK4, ALK7, BMPR1A, BMPR1B, BMPR2, MISR2, TGFbR1, TGFbR2 |
||
| CK1 |
11 |
CK1 |
7 |
CK1a, CK1a2, CK1d, CK1e, CK1g1, CK1g2, CK1g3 |
| TTBK |
2 |
TTBK1, TTBK2 |
||
| VRK |
2 |
VRK1, VRK2 |
||
| Other |
63 |
Aur |
3 |
AurA, AurB, AurC |
| BUB |
1 |
BUB1 |
||
| Bud32 |
1 |
PRPK |
||
| CAMKK |
2 |
CaMKK1, CaMKK2 |
||
| CDC7 |
1 |
CDC7 |
||
| CK2 |
2 |
CK2a1, CK2a2 |
||
| IKK |
4 |
IKKa, IKKb, IKKe, TBK1 |
||
| IRE |
2 |
IRE1, IRE2 |
||
| MOS |
1 |
MOS |
||
| NAK |
4 |
AAK1, BIKE, GAK, MPSK1 |
||
| NEK |
11 |
NEK1, NEK2, NEK3, NEK4, NEK5, NEK6, NEK7, NEK8, NEK9, NEK10, NEK11 |
||
| NKF1 |
3 |
SBK, SgK069, SgK110 |
||
| NKF2 |
1 |
PINK1 |
||
| NKF4 |
2 |
CLIK1, CLIK1L |
||
| PEK |
4 |
GCN2, HRI, PEK, PKR |
||
| PLK |
4 |
PLK1, PLK2, PLK3, PLK4 |
||
| TLK |
2 |
TLK1, TLK2 |
||
| TOPK |
1 |
PBK |
||
| TTK |
1 |
TTK |
||
| ULK |
4 |
Fused, ULK1, ULK2, ULK3 |
||
| VPS15 |
1 |
PIK3R4 |
||
| WEE |
3 |
MYT1, Wee1, Wee1B |
||
| Wnk |
4 |
Wnk1, Wnk2, Wnk3, Wnk4 |
||
| Other-Unique |
2 |
KIS, SgK496 |
||
Hanks Genome Biology 2003 4:111 doi:10.1186/gb-2003-4-5-111 |
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