Genome Biology

official impact factor 6.89

This article has not been peer reviewed.

Highly Access

DAVID: Database for Annotation, Visualization, and Integrated Discovery

Glynn Dennis*, Brad T Sherman, Douglas A Hosack, Jun Yang, Wei Gao, H Clifford Lane and Richard A Lempicki

Genome Biology 2003, 4:P3 doi:10.1186/gb-2003-4-5-p3

Accesses  

  • Last 30 days: 375 accesses
  • Last year: 3925 accesses
  • All time: 29073 accesses

Cited by

BioMed Central: 224 citations

Research article   Open Access

Genome-wide analysis of hepatic LRH-1 reveals a promoter binding preference and suggests a role in regulating genes of lipid metabolism in concert with FXR

Hansook Kim Chong, Jacob Biesinger, Young-Kyo Seo, Xiaohui Xie, Timothy F Osborne BMC Genomics 2012, 13:51 (1 February 2012)

Research article   Open Access

Genome-wide landscape of liver X receptor chromatin binding and gene regulation in human macrophages

Petri Pehkonen, Lynn Welter-Stahl, Janine Diwo, Jussi Ryynanen, Anke Wienecke-Baldacchino, Sami Heikkinen, Eckardt Treuter, Knut R Steffensen, Carsten Carlberg BMC Genomics 2012, 13:50 (31 January 2012)

Research   Open Access

Suppression of Cancer Stemness p21-regulating mRNA and microRNA Signatures in Recurrent Ovarian Cancer Patient Samples

Michael F Gallagher, Cynthia CBB Heffron, Alexandros Laios, Sharon A O'Toole, Brendan Ffrench, Paul C Smyth, Richard J Flavin, Salah A Elbaruni, Cathy D Spillane, Cara M Martin, Orla M Shelis, John J O'Leary Journal of Ovarian Research 2012, 5:2 (19 January 2012)

Proceedings   Open Access

Improving ChIP-seq peak-calling for functional co-regulator binding by integrating multiple sources of biological information

Hatice Osmanbeyoglu, Ryan J Hartmaier, Steffi Oesterreich, Xinghua Lu BMC Genomics 2012, 13(Suppl 1):S1 (17 January 2012)

Research article   Open Access

Protease-associated cellular networks in malaria parasite Plasmodium falciparum

Timothy G Lilburn, Hong Cai, Zhan Zhou, Yufeng Wang BMC Genomics 2011, 12(Suppl 5):S9 (23 December 2011)

Research article   Open Access Highly Accessed

Regulatory coordination of clustered microRNAs based on microRNA-transcription factor regulatory network

Jin Wang, Martin Haubrock, Kun-Ming Cao, Xu Hua, Chen-Yu Zhang, Edgar Wingender, Jie Li BMC Systems Biology 2011, 5:199 (16 December 2011)

Proceedings   Open Access

Exploring molecular links between lymph node invasion and cancer prognosis in human breast cancer

Sangwoo Kim, Hojung Nam, Doheon Lee BMC Systems Biology 2011, 5(Suppl 2):S4 (14 December 2011)

Proceedings   Open Access

A robust tool for discriminative analysis and feature selection in paired samples impacts the identification of the genes essential for reprogramming lung tissue to adenocarcinoma

Swee Toh, Philip Prathipati, Efthimios Motakis, Chee Keong Kwoh, Surya Yenamandra, Vladimir A Kuznetsov BMC Genomics 2011, 12(Suppl 3):S24 (30 November 2011)

Proceedings   Open Access

Construction and analysis of the protein-protein interaction networks for schizophrenia, bipolar disorder, and major depression

Sheng-An Lee, Theresa Tsao, Ko-Chun Yang, Han Lin, Yu-Lun Kuo, Chien-Hsiang Hsu, Wen-Kuei Lee, Kuo-Chuan Huang, Cheng-Yan Kao BMC Bioinformatics 2011, 12(Suppl 13):S20 (30 November 2011)

Research article   Open Access Highly Accessed

Genome-wide analysis of gene expression during Xenopus tropicalis tadpole tail regeneration

Nick R Love, Yaoyao Chen, Boyan Bonev, Michael J Gilchrist, Lynne Fairclough, Robert Lea, Timothy J Mohun, Roberto Paredes, Leo AH Zeef, Enrique Amaya BMC Developmental Biology 2011, 11:70 (15 November 2011)

Research article   Open Access

Sex-dimorphism in Cardiac Nutrigenomics: effect of Trans fat and/or Monosodium Glutamate consumption

Kate S Collison, Marya Z Zaidi, Zakia Maqbool, Soad M Saleh, Angela Inglis, Nadine J Makhoul, Razan Bakheet, Mohammed Shoukri, Futwan A Al-Mohanna BMC Genomics 2011, 12:555 (12 November 2011)

Research article   Open Access

Identification of common and cell type specific LXXLL motif EcR cofactors using a bioinformatics refined candidate RNAi screen in Drosophila melanogaster cell lines

Melissa B Davis, Inigo SanGil, Grace Berry, Rashidat Olayokun, Lori H Neves BMC Developmental Biology 2011, 11:66 (3 November 2011)

Research article   Open Access

Comparison of static immersion and intravenous injection systems for exposure of zebrafish embryos to the natural pathogen Edwardsiella tarda

Joost J van Soest, Oliver W Stockhammer, Anita Ordas, Guido V Bloemberg, Herman P Spaink, Annemarie H Meijer BMC Immunology 2011, 12:58 (17 October 2011)

Research article   Open Access Highly Accessed

Meta-analysis and genome-wide interpretation of genetic susceptibility to drug addiction

Chuan-Yun Li, Wei-Zhen Zhou, Ping-Wu Zhang, Catherine Johnson, Liping Wei, George R Uhl BMC Genomics 2011, 12:508 (15 October 2011)

Methodology article   Open Access Highly Accessed

Identifying cancer biomarkers by network-constrained support vector machines

Li Chen, Jianhua Xuan, Rebecca B Riggins, Robert Clarke, Yue Wang BMC Systems Biology 2011, 5:161 (12 October 2011)

Research article   Open Access Highly Accessed

Genome-wide mapping of Sox6 binding sites in skeletal muscle reveals both direct and indirect regulation of muscle terminal differentiation by Sox6

Chung-Il An, Yao Dong, Nobuko Hagiwara BMC Developmental Biology 2011, 11:59 (10 October 2011)

Research article   Open Access

Deciphering c-MYC-regulated genes in two distinct tissues

Samuel C Robson, Lesley Ward, Helen Brown, Heather Turner, Ewan Hunter, Stella Pelengaris, Michael Khan BMC Genomics 2011, 12:476 (30 September 2011)

Research article   Open Access

Genome-wide examination of the transcriptional response to ecdysteroids 20-hydroxyecdysone and ponasterone A in Drosophila melanogaster

Sarah E Gonsalves, Scott J Neal, Amy S Kehoe, J Westwood BMC Genomics 2011, 12:475 (29 September 2011)

Research article   Open Access

Decreased expression of B cell related genes in leukocytes of women with Parkinson's disease

Merav Kedmi, Anat Bar-Shira, Tanya Gurevich, Nir Giladi, Avi Orr-Urtreger Molecular Neurodegeneration 2011, 6:66 (23 September 2011)

Software   Open Access Highly Accessed

Cistrome: an integrative platform for transcriptional regulation studies

Tao Liu, Jorge A Ortiz, Len Taing, Clifford A Meyer, Bernett Lee, Yong Zhang, Hyunjin Shin, Swee S Wong, Jian Ma, Ying Lei, Utz J Pape, Michael Poidinger, Yiwen Chen, Kevin Yeung, Myles Brown, Yaron Turpaz, X Shirley Liu Genome Biology 2011, 12:R83 (22 August 2011)

A Galaxy-based web application for integrative analysis of ChIP data

Research article   Open Access

Histological and transcriptome-wide level characteristics of fetal myofiber hyperplasia during the second half of gestation in Texel and Ujumqin sheep

Hangxing Ren, Li Li, Hongwei Su, Lingyang Xu, Caihong Wei, Li Zhang, Hongbin Li, Wenzhong Liu, Lixin Du BMC Genomics 2011, 12:411 (14 August 2011)

Research article   Open Access

Transcriptome analysis of embryonic mammary cells reveals insights into mammary lineage establishment

Olivia Wansbury, Alan Mackay, Naoko Kogata, Costas Mitsopoulos, Howard Kendrick, Kathryn Davidson, Christiana Ruhrberg, Jorge S Reis-Filho, Matthew J Smalley, Marketa Zvelebil, Beatrice A Howard Breast Cancer Research 2011, 13:R79 (11 August 2011)

Research   Open Access

Comparison of human glomerulus proteomic profiles obtained from low quantities of samples by different mass spectrometry with the comprehensive database

Ying Zhang, Yutaka Yoshida, Bo Xu, Sameh Magdeldin, Hidehiko Fujinaka, Zan Liu, Masahito Miyamoto, Eishin Yaoita, Tadashi Yamamoto Proteome Science 2011, 9:47 (10 August 2011)

Short Report   Open Access

Limited redundancy in genes regulated by Cyclin T2 and Cyclin T1

Rajesh Ramakrishnan, Wendong Yu, Andrew P Rice BMC Research Notes 2011, 4:260 (26 July 2011)

Research article   Open Access

Integration of Genome-Wide Computation DRE Search, AhR ChIP-chip and Gene Expression Analyses of TCDD-Elicited Responses in the Mouse Liver

Edward Dere, Raymond Lo, Trine Celius, Jason Matthews, Timothy R Zacharewski BMC Genomics 2011, 12:365 (15 July 2011)

Methodology   Open Access

Genome-wide mapping of imprinted differentially methylated regions by DNA methylation profiling of human placentas from triploidies

Ryan KC Yuen, Ruby Jiang, Maria S Peñaherrera, Deborah E McFadden, Wendy P Robinson Epigenetics & Chromatin 2011, 4:10 (13 July 2011)

Research   Open Access Highly Accessed

Analysis of EGFR signaling pathway in nasopharyngeal carcinoma cells by quantitative phosphoproteomics

Lin Ruan, Xin-Hui Li, Xun-Xun Wan, Hong Yi, Cui Li, Mao-Yu Li, Peng-Fei Zhang, Gu-Qing Zeng, Jia-Quan Qu, Qiu-Yan He, Jian-Huang Li, Yu Chen, Zhu-Chu Chen, Zhi-Qiang Xiao Proteome Science 2011, 9:35 (28 June 2011)

Research   Open Access Highly Accessed

Expression analysis of asthma candidate genes during human and murine lung development

Erik Melén, Alvin T Kho, Sunita Sharma, Roger Gaedigk, J Steven Leeder, Thomas J Mariani, Vincent J Carey, Scott T Weiss, Kelan G Tantisira Respiratory Research 2011, 12:86 (23 June 2011)

Research article   Open Access Highly Accessed

Staphylococcus aureus Biofilm and Planktonic cultures differentially impact gene expression, mapk phosphorylation, and cytokine production in human keratinocytes

Patrick R Secor, Garth A James, Philip Fleckman, John E Olerud, Kate McInnerney, Philip S Stewart BMC Microbiology 2011, 11:143 (21 June 2011)

Proceedings   Open Access

Jejunal gene expression patterns correlate with severity of systemic infection in chicken

Dirkjan Schokker, Mari A Smits, Johanna MJ Rebel BMC Proceedings 2011, 5(Suppl 4):S4 (3 June 2011)

Research   Open Access

Integrated metabolome and transcriptome analysis of the NCI60 dataset

Gang Su, Charles F Burant, Christopher W Beecher, Brian D Athey, Fan Meng BMC Bioinformatics 2011, 12(Suppl 1):S36 (15 February 2011)

Research   Open Access

Investigation gene and microRNA expression in glioblastoma

Hua Dong, Hoicheong Siu, Li Luo, Xiangzhong Fang, Li Jin, Momiao Xiong BMC Genomics 2010, 11(Suppl 3):S16 (1 December 2010)

Research article   Open Access Highly Accessed

Global transcriptional profiles of beating clusters derived from human induced pluripotent stem cells and embryonic stem cells are highly similar

Manoj K Gupta, Damir J Illich, Andrea Gaarz, Matthias Matzkies, Filomain Nguemo, Kurt Pfannkuche, Huamin Liang, Sabine Classen, Michael Reppel, Joachim L Schultze, Jürgen Hescheler, Tomo Šarić BMC Developmental Biology 2010, 10:98 (15 September 2010)

Research   Open Access

Copy number and gene expression differences between African American and Caucasian American prostate cancer

Amy E Rose, Jaya M Satagopan, Carole Oddoux, Qin Zhou, Ruliang Xu, Adam B Olshen, Jessie Z Yu, Atreya Dash, Jerome Jean-Gilles, Victor Reuter, William L Gerald, Peng Lee, Iman Osman Journal of Translational Medicine 2010, 8:70 (22 July 2010)

Research   Open Access Highly Accessed

Gene expression profiling of mouse p53-deficient epidermal carcinoma defines molecular determinants of human cancer malignancy

Ramón García-Escudero, Ana B Martínez-Cruz, Mirentxu Santos, Corina Lorz, Carmen Segrelles, Guillermo Garaulet, Cristina Saiz-Ladera, Clotilde Costa, Águeda Buitrago-Pérez, Marta Dueñas, Jesús M Paramio Molecular Cancer 2010, 9:193 (14 July 2010)

Brief reports   Open Access

GTC: A web server for integrating systems biology data with web tools and desktop applications

Dan Tenenbaum, J Christopher Bare, Nitin S Baliga Source Code for Biology and Medicine 2010, 5:7 (13 July 2010)

Methodology article   Open Access Highly Accessed

PCA2GO: a new multivariate statistics based method to identify highly expressed GO-Terms

Marc Bruckskotten, Mario Looso, Franz Cemiĉ, Anne Konzer, Jürgen Hemberger, Marcus Krüger, Thomas Braun BMC Bioinformatics 2010, 11:336 (21 June 2010)

Research article   Open Access

A gene network switch enhances the oxidative capacity of ovine skeletal muscle during late fetal development

Keren Byrne, Tony Vuocolo, Cedric Gondro, Jason D White, Noelle E Cockett, Tracy Hadfield, Christopher A Bidwell, Jolena N Waddell, Ross L Tellam BMC Genomics 2010, 11:378 (15 June 2010)

Research article   Open Access

Transcriptional regulation of gene expression clusters in motor neurons following spinal cord injury

Jesper Ryge, Ole Winther, Jacob Wienecke, Albin Sandelin, Ann-Charlotte Westerdahl, Hans Hultborn, Ole Kiehn BMC Genomics 2010, 11:365 (9 June 2010)

Research article   Open Access

Bayesian integrated modeling of expression data: a case study on RhoG

Rashi Gupta, Dario Greco, Petri Auvinen, Elja Arjas BMC Bioinformatics 2010, 11:295 (1 June 2010)

Research article   Open Access Highly Accessed

Bioinformatic identification and characterization of human endothelial cell-restricted genes

Manoj Bhasin, Lei Yuan, Derin B Keskin, Hasan H Otu, Towia A Libermann, Peter Oettgen BMC Genomics 2010, 11:342 (28 May 2010)

Research article   Open Access

Benzo(a)pyrene induces similar gene expression changes in testis of DNA repair proficient and deficient mice

Nicole Verhofstad, Jeroen LA Pennings, Conny van Oostrom, Jan van Benthem, Frederik J van Schooten, Harry van Steeg, Roger WL Godschalk BMC Genomics 2010, 11:333 (26 May 2010)

Research article   Open Access

Functional and gene network analyses of transcriptional signatures characterizing pre-weaned bovine mammary parenchyma or fat pad uncovered novel inter-tissue signaling networks during development

Paola Piantoni, Massimo Bionaz, Daniel E Graugnard, Kristy M Daniels, Robin E Everts, Sandra L Rodriguez-Zas, Harris A Lewin, Hurley L Hurley, Michael Akers, Juan J Loor BMC Genomics 2010, 11:331 (26 May 2010)

Software   Open Access

PhenoFam-gene set enrichment analysis through protein structural information

Maciej Paszkowski-Rogacz, Mikolaj Slabicki, M Teresa Pisabarro, Frank Buchholz BMC Bioinformatics 2010, 11:254 (17 May 2010)

Research article   Open Access

Meta-analysis of archived DNA microarrays identifies genes regulated by hypoxia and involved in a metastatic phenotype in cancer cells

Michael Pierre, Benoît DeHertogh, Anthoula Gaigneaux, Bertrand DeMeulder, Fabrice Berger, Eric Bareke, Carine Michiels, Eric Depiereux BMC Cancer 2010, 10:176 (30 April 2010)

Research article   Open Access Highly Accessed

Identification of copy number variations and common deletion polymorphisms in cattle

Joon Bae, Hyun Cheong, Lyoung Kim, Suk NamGung, Tae Park, Ji-Yong Chun, Jason Kim, Charisse Pasaje, Jin Lee, Hyoung Shin BMC Genomics 2010, 11:232 (9 April 2010)

Research article   Open Access Highly Accessed

Whole transcriptome analysis of the hippocampus: toward a molecular portrait of epileptogenesis

Oswaldo K Okamoto, Luciana Janjoppi, Felipe M Bonone, Aline P Pansani, Alexandre V da Silva, Fúlvio A Scorza, Esper A Cavalheiro BMC Genomics 2010, 11:230 (8 April 2010)

Research   Open Access

Akt regulates the expression of MafK, synaptotagmin I, and syntenin-1, which play roles in neuronal function

Young-Tae Ro, Bo-Kwang Jang, Chan Shin, Eui U Park, Chul Kim, Sung-Il Yang Journal of Biomedical Science 2010, 17:18 (17 March 2010)

Method   Open Access Highly Accessed

Identification of functional modules that correlate with phenotypic difference: the influence of network topology

Jui-Hung Hung, Troy W Whitfield, Tun-Hsiang Yang, Zhenjun Hu, Zhiping Weng, Charles DeLisi Genome Biology 2010, 11:R23 (26 February 2010)

A gene set enrichment analysis method for including network topology in the identification of genes involved in phenotypic alterations is described. Classifications: Genome studies, Methods

Research article   Open Access

Pediatric primary central nervous system germ cell tumors of different prognosis groups show characteristic miRNome traits and chromosome copy number variations

Hsei-Wei Wang, Yu-Hsuan Wu, Jui-Yu Hsieh, Muh-Lii Liang, Meng-En Chao, Da-Jung Liu, Ming-Ta Hsu, Tai-Tong Wong BMC Genomics 2010, 11:132 (24 February 2010)

Research article   Open Access

Expression profiling of mouse embryonic fibroblasts with a deletion in the helicase domain of the Werner Syndrome gene homologue treated with hydrogen peroxide

Adam Labbé, Ramachander VN Turaga, Éric R Paquet, Chantal Garand, Michel Lebel BMC Genomics 2010, 11:127 (22 February 2010)

Research article   Open Access Highly Accessed

Cellular processes of v-Src transformation revealed by gene profiling of primary cells - Implications for human cancer

Bart M Maślikowski, Benjamin D Néel, Ying Wu, Lizhen Wang, Natalie A Rodrigues, Germain Gillet, Pierre-André Bédard BMC Cancer 2010, 10:41 (12 February 2010)

Research   Open Access

Proteomic analysis of prolactinoma cells by immuno-laser capture microdissection combined with online two-dimensional nano-scale liquid chromatography/mass spectrometry

Yingchao Liu, Jinsong Wu, Guoquan Yan, Ruiping Hou, Dongxiao Zhuang, Luping Chen, Qi Pang, Jianhong Zhu Proteome Science 2010, 8:2 (29 January 2010)

Research article   Open Access

Relationship between operon preference and functional properties of persistent genes in bacterial genomes

Marit S Bratlie, Jostein Johansen, Finn Drabløs BMC Genomics 2010, 11:71 (28 January 2010)

Research article   Open Access

Transcriptional adaptations following exercise in Thoroughbred horse skeletal muscle highlights molecular mechanisms that lead to muscle hypertrophy

Beatrice A McGivney, Suzanne S Eivers, David E MacHugh, James N MacLeod, Grace M O'Gorman, Stephen DE Park, Lisa M Katz, Emmeline W Hill BMC Genomics 2009, 10:638 (30 December 2009)

Research article   Open Access

Increased epithelial stem cell traits in advanced endometrial endometrioid carcinoma

Shing-Jyh Chang, Tao-Yeuan Wang, Chan-Yen Tsai, Tzu-Fang Hu, Margaret Chang, Hsei-Wei Wang BMC Genomics 2009, 10:613 (16 December 2009)

Research article   Open Access

Global transcriptional response after exposure of fission yeast cells to ultraviolet light

Henriette C Skjølberg, Øyvind Fensgård, Hilde Nilsen, Beáta Grallert, Erik Boye BMC Cell Biology 2009, 10:87 (16 December 2009)

Research article   Open Access

Dissecting the dynamics of dysregulation of cellular processes in mouse mammary gland tumor

Wieslawa I Mentzen, Matteo Floris, Alberto de la Fuente BMC Genomics 2009, 10:601 (13 December 2009)

Research article   Open Access Highly Accessed

Deciphering the transcriptional circuitry of microRNA genes expressed during human monocytic differentiation

Sebastian Schmeier, Cameron R MacPherson, Magbubah Essack, Mandeep Kaur, Ulf Schaefer, Harukazu Suzuki, Yoshihide Hayashizaki, Vladimir B Bajic BMC Genomics 2009, 10:595 (10 December 2009)

This article is part of a collection on FANTOM4

Research article   Open Access

RNA profiles of rat olfactory epithelia: individual and age related variations

Maud Rimbault, Stéphanie Robin, Amaury Vaysse, Francis Galibert BMC Genomics 2009, 10:572 (2 December 2009)

Methodology article   Open Access Highly Accessed

Illumina WG-6 BeadChip strips should be normalized separately

Wei Shi, Ashish Banerjee, Matthew E Ritchie, Steve Gerondakis, Gordon K Smyth BMC Bioinformatics 2009, 10:372 (11 November 2009)

Research article   Open Access Highly Accessed

Identification of differentially expressed miRNAs in chicken lung and trachea with avian influenza virus infection by a deep sequencing approach

Ying Wang, Vinayak Brahmakshatriya, Huifeng Zhu, Blanca Lupiani, Sanjay M Reddy, Byung-Jun Yoon, Preethi H Gunaratne, Jong Kim, Rui Chen, Junjun Wang, Huaijun Zhou BMC Genomics 2009, 10:512 (5 November 2009)

Research article   Open Access Highly Accessed

Transcriptome analysis of differentiating trypanosomes reveals the existence of multiple post-transcriptional regulons

Rafael Queiroz, Corinna Benz, Kurt Fellenberg, Jörg D Hoheisel, Christine Clayton BMC Genomics 2009, 10:495 (26 October 2009)

Research article   Open Access

Expulsion of Trichuris muris is associated with increased expression of angiogenin 4 in the gut and increased acidity of mucins within the goblet cell

Riccardo D'Elia, Matthew L deSchoolmeester, Leo AH Zeef, Steven H Wright, Alan D Pemberton, Kathryn J Else BMC Genomics 2009, 10:492 (24 October 2009)

Proceedings   Open Access

Site-specific impacts on gene expression and behavior in fathead minnows (Pimephales promelas) exposed in situ to streams adjacent to sewage treatment plants

Natàlia Garcia-Reyero, Ira R Adelman, Dalma Martinović, Li Liu, Nancy D Denslow BMC Bioinformatics 2009, 10(Suppl 11):S11 (8 October 2009)

Proceedings   Open Access

Comparing gene annotation enrichment tools for functional modeling of agricultural microarray data

Bart Berg, Chamali Thanthiriwatte, Prashanti Manda, Susan M Bridges BMC Bioinformatics 2009, 10(Suppl 11):S9 (8 October 2009)

Methodology article   Open Access

Generation of Gene Ontology benchmark datasets with various types of positive signal

Petri Törönen, Petri Pehkonen, Liisa Holm BMC Bioinformatics 2009, 10:319 (7 October 2009)

Research article   Open Access

Early over expression of messenger RNA for multiple genes, including insulin, in the Pancreatic Lymph Nodes of NOD mice is associated with Islet Autoimmunity

Béatrice Regnault, José Osorio y Fortea, Dongmei Miao, George Eisenbarth, Evie Melanitou BMC Medical Genomics 2009, 2:63 (2 October 2009)

Research   Open Access

Molecular networks involved in mouse cerebral corticogenesis and spatio-temporal regulation of Sox4 and Sox11 novel antisense transcripts revealed by transcriptome profiling

King-Hwa Ling, Chelsee A Hewitt, Tim Beissbarth, Lavinia Hyde, Kakoli Banerjee, Pike-See Cheah, Ping Z Cannon, Christopher N Hahn, Paul Q Thomas, Gordon K Smyth, Seong-Seng Tan, Tim Thomas, Hamish S Scott Genome Biology 2009, 10:R104 (2 October 2009)

SAGE analysis reveals spatiotemporally regulated transcripts and overlapping sense and antisense transcripts that are important for mouse cerebral cortex development

Research article   Open Access

Robust extraction of functional signals from gene set analysis using a generalized threshold free scoring function

Petri Törönen, Pauli J Ojala, Pekka Marttinen, Liisa Holm BMC Bioinformatics 2009, 10:307 (23 September 2009)

Research article   Open Access Highly Accessed

Effects of typical and atypical antipsychotic drugs on gene expression profiles in the liver of schizophrenia subjects

Kwang H Choi, Brandon W Higgs, Serge Weis, Jonathan Song, Ida C Llenos, Jeannette R Dulay, Robert H Yolken, Maree J Webster BMC Psychiatry 2009, 9:57 (16 September 2009)

Both typical and atypical antipsychotics affect different biological processes in the liver by changing gene expression profiles, providing valuable information for the development of future drugs with less side effects.

Research article   Open Access Highly Accessed

Gene expression profiling of human alveolar macrophages infected by B. anthracis spores demonstrates TNF-α and NF-κb are key components of the innate immune response to the pathogen

Mikhail Dozmorov, Wenxin Wu, Kaushik Chakrabarty, J Leland Booth, Robert E Hurst, K Mark Coggeshall, Jordan P Metcalf BMC Infectious Diseases 2009, 9:152 (10 September 2009)

Research article   Open Access Highly Accessed

Gene expression down-regulation in CD90+ prostate tumor-associated stromal cells involves potential organ-specific genes

Laura E Pascal, Young Goo, Ricardo ZN Vêncio, Laura S Page, Amber A Chambers, Emily S Liebeskind, Thomas K Takayama, Lawrence D True, Alvin Y Liu BMC Cancer 2009, 9:317 (8 September 2009)

Software   Open Access Highly Accessed

Genephony: a knowledge management tool for genome-wide research

Angelo Nuzzo, Alberto Riva BMC Bioinformatics 2009, 10:278 (3 September 2009)

Research   Open Access Highly Accessed

Expression profiling identifies genes involved in emphysema severity

Santiyagu Francis, Jill E Larsen, Sandra J Pavey, Rayleen V Bowman, Nicholas K Hayward, Kwun M Fong, Ian A Yang Respiratory Research 2009, 10:81 (2 September 2009)

Research article   Open Access Highly Accessed

Weighted gene co-expression network analysis of the peripheral blood from Amyotrophic Lateral Sclerosis patients

Christiaan GJ Saris, Steve Horvath, Paul WJ van Vught, Michael A van Es, Hylke M Blauw, Tova F Fuller, Peter Langfelder, Joseph DeYoung, John HJ Wokke, Jan H Veldink, Leonard H van den Berg, Roel A Ophoff BMC Genomics 2009, 10:405 (27 August 2009)

Research article   Open Access Highly Accessed

Integrating microRNA and mRNA expression profiles of neuronal progenitors to identify regulatory networks underlying the onset of cortical neurogenesis

Joseph A Nielsen, Pierre Lau, Dragan Maric, Jeffery L Barker, Lynn D Hudson BMC Neuroscience 2009, 10:98 (19 August 2009)

Research article   Open Access Highly Accessed

Combined genome-wide expression profiling and targeted RNA interference in primary mouse macrophages reveals perturbation of transcriptional networks associated with interferon signalling

Paul Lacaze, Sobia Raza, Garwin Sing, David Page, Thorsten Forster, Petter Storm, Marie Craigon, Tarif Awad, Peter Ghazal, Tom C Freeman BMC Genomics 2009, 10:372 (10 August 2009)

Research article   Open Access Highly Accessed

The steady-state transcriptome of the four major life-cycle stages of Trypanosoma cruzi

Todd A Minning, D Brent Weatherly, James Atwood, Ron Orlando, Rick L Tarleton BMC Genomics 2009, 10:370 (7 August 2009)

Research article   Open Access Highly Accessed

Candidate pathways and genes for prostate cancer: a meta-analysis of gene expression data

Ivan P Gorlov, Jinyoung Byun, Olga Y Gorlova, Ana M Aparicio, Eleni Efstathiou, Christopher J Logothetis BMC Medical Genomics 2009, 2:48 (4 August 2009)

Research article   Open Access Highly Accessed

Detection of differentially expressed genes between Erhualian and Large White placentas on day 75 and 90 of gestation

Quan-Yong Zhou, Ming-Di Fang, Ting-Hua Huang, Chang-Chun Li, Mei Yu, Shu-Hong Zhao BMC Genomics 2009, 10:337 (26 July 2009)

Research article   Open Access

Identification of pediatric septic shock subclasses based on genome-wide expression profiling

Hector R Wong, Natalie Cvijanovich, Richard Lin, Geoffrey L Allen, Neal J Thomas, Douglas F Willson, Robert J Freishtat, Nick Anas, Keith Meyer, Paul A Checchia, Marie Monaco, Kelli Odom, Thomas P Shanley BMC Medicine 2009, 7:34 (22 July 2009)

Genome-wide expression profiling allows the classification of pediatric septic shock into three distinct subclasses, which may enable the design of specific therapies, particularly targeted at the adaptive immune system and zinc homeostasis.

Research article   Open Access Highly Accessed

In silico identification of a core regulatory network of OCT4 in human embryonic stem cells using an integrated approach

Lukas Chavez, Abha S Bais, Martin Vingron, Hans Lehrach, James Adjaye, Ralf Herwig BMC Genomics 2009, 10:314 (15 July 2009)

Research article   Open Access

Genome wide analysis of human genes transcriptionally and post-transcriptionally regulated by the HTLV-I protein p30

John M Taylor, Sofiane Ghorbel, Christophe Nicot BMC Genomics 2009, 10:311 (14 July 2009)

Research article   Open Access Highly Accessed

OHMM: a Hidden Markov Model accurately predicting the occupancy of a transcription factor with a self-overlapping binding motif

Amar Drawid, Nupur Gupta, Vijayalakshmi H Nagaraj, Céline Gélinas, Anirvan M Sengupta BMC Bioinformatics 2009, 10:208 (7 July 2009)

Research   Open Access

Annotating the human genome with Disease Ontology

John D Osborne, Jared Flatow, Michelle Holko, Simon M Lin, Warren A Kibbe, Lihua Zhu, Maria I Danila, Gang Feng, Rex L Chisholm BMC Genomics 2009, 10(Suppl 1):S6 (7 July 2009)

Software   Open Access Highly Accessed

Seeking unique and common biological themes in multiple gene lists or datasets: pathway pattern extraction pipeline for pathway-level comparative analysis

Ming Yi, Uma Mudunuri, Anney Che, Robert M Stephens BMC Bioinformatics 2009, 10:200 (29 June 2009)

Research article   Open Access

Discernment of possible mechanisms of hepatotoxicity via biological processes over-represented by co-expressed genes

Jeff W Chou, Pierre R Bushel BMC Genomics 2009, 10:272 (18 June 2009)

Research   Open Access

Proteins recruited by SH3 domains of Ruk/CIN85 adaptor identified by LC-MS/MS

Serhiy Havrylov, Yuriy Rzhepetskyy, Agata Malinowska, Lyudmyla Drobot, Maria Redowicz Proteome Science 2009, 7:21 (16 June 2009)

Proceedings   Open Access

Human microRNA target analysis and gene ontology clustering by GOmir, a novel stand-alone application

Maria G Roubelakis, Pantelis Zotos, Georgios Papachristoudis, Ioannis Michalopoulos, Kalliopi I Pappa, Nicholas P Anagnou, Sophia Kossida BMC Bioinformatics 2009, 10(Suppl 6):S20 (16 June 2009)

Research article   Open Access Highly Accessed

Mutations in many genes affect aggressive behavior in Drosophila melanogaster

Alexis C Edwards, Liesbeth Zwarts, Akihiko Yamamoto, Patrick Callaerts, Trudy FC Mackay BMC Biology 2009, 7:29 (11 June 2009)

Aggressive behavior in Drosophila melanogaster is a complex trait and 57 genes influencing aggression levels have now been identified in a screen of fly lines carrying P-element insertions.

Research article   Open Access Highly Accessed

Integrated analysis of DNA methylation and gene expression reveals specific signaling pathways associated with platinum resistance in ovarian cancer

Meng Li, Curt Balch, John S Montgomery, Mikyoung Jeong, Jae Chung, Pearlly Yan, Tim HM Huang, Sun Kim, Kenneth P Nephew BMC Medical Genomics 2009, 2:34 (8 June 2009)

Research   Open Access Highly Accessed

Gene and microRNA analysis of neutrophils from patients with polycythemia vera and essential thrombocytosis: down-regulation of micro RNA-1 and -133a

Stefanie Slezak, Ping Jin, Lorraine Caruccio, Jiaqiang Ren, Michael Bennett, Nausheen Zia, Sharon Adams, Ena Wang, Joao Ascensao, Geraldine Schechter, David Stroncek Journal of Translational Medicine 2009, 7:39 (4 June 2009)

Research article   Open Access Highly Accessed

Prediction of HIV-1 virus-host protein interactions using virus and host sequence motifs

Perry Evans, William Dampier, Lyle Ungar, Aydin Tozeren BMC Medical Genomics 2009, 2:27 (18 May 2009)

Research article   Open Access

Distinct gene-expression profiles characterize mammary tumors developed in transgenic mice expressing constitutively active and C-terminally truncated variants of STAT5

Tali Eilon, Itamar Barash BMC Genomics 2009, 10:231 (18 May 2009)

Primary research   Open Access

Gene expression profiling predicts a three-gene expression signature of endometrial adenocarcinoma in a rat model

Sandra Karlsson, Björn Olsson, Karin Klinga-Levan Cancer Cell International 2009, 9:12 (8 May 2009)

Research   Open Access

Use of serial analysis of gene expression to reveal the specific regulation of gene expression profile in asthmatic rats treated by acupuncture

Lei-Miao Yin, Gong-Hao Jiang, Yu Wang, Yan Wang, Yan-Yan Liu, Wei-Rong Jin, Yu-Dong Xu, Qing-Hua Zhang, Yong-Qing Yang Journal of Biomedical Science 2009, 16:46 (6 May 2009)

Research   Open Access Highly Accessed

Comprehensive proteomic analysis of human cervical-vaginal fluid using colposcopy samples

Geert Zegels, Geert AA Van Raemdonck, Edmond P Coen, Wiebren AA Tjalma, Xaveer WM Van Ostade Proteome Science 2009, 7:17 (17 April 2009)

Research article   Open Access Highly Accessed

Transcription and splicing regulation in human umbilical vein endothelial cells under hypoxic stress conditions by exon array

Xingyi Hang, Peiyao Li, Zhifeng Li, Wubin Qu, Ying Yu, Hualing Li, Zhiyong Shen, Hao Zheng, Yan Gao, Yonghong Wu, Minghua Deng, Zhixian Sun, Chenggang Zhang BMC Genomics 2009, 10:126 (25 March 2009)

Research   Open Access Highly Accessed

MicroRNA and gene expression patterns in the differentiation of human embryonic stem cells

Jiaqiang Ren, Ping Jin, Ena Wang, Francesco M Marincola, David F Stroncek Journal of Translational Medicine 2009, 7:20 (23 March 2009)

Research   Open Access

Toxicogenomic analysis of susceptibility to inhaled urban particulate matter in mice with chronic lung inflammation

Errol M Thomson, Andrew Williams, Carole L Yauk, Renaud Vincent Particle and Fibre Toxicology 2009, 6:6 (11 March 2009)

Research article   Open Access Highly Accessed

Rapid evolution of mammalian X-linked testis microRNAs

Xuejiang Guo, Bing Su, Zuomin Zhou, Jiahao Sha BMC Genomics 2009, 10:97 (4 March 2009)

Research article   Open Access Highly Accessed

Somatic, germline and sex hierarchy regulated gene expression during Drosophila metamorphosis

Matthew S Lebo, Laura E Sanders, Fengzhu Sun, Michelle N Arbeitman BMC Genomics 2009, 10:80 (13 February 2009)

Research article   Open Access Highly Accessed

Understanding Haemophilus parasuis infection in porcine spleen through a transcriptomics approach

Hongbo Chen, Changchun Li, Mingdi Fang, Mengjin Zhu, Xinyun Li, Rui Zhou, Kui Li, Shuhong Zhao BMC Genomics 2009, 10:64 (5 February 2009)

Software   Open Access Highly Accessed

GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists

Eran Eden, Roy Navon, Israel Steinfeld, Doron Lipson, Zohar Yakhini BMC Bioinformatics 2009, 10:48 (3 February 2009)

Research article   Open Access Highly Accessed

A Candida albicans early stage biofilm detachment event in rich medium

Adnane Sellam, Thamir Al-Niemi, Kathleen McInnerney, Susan Brumfield, Andre Nantel, Peter A Suci BMC Microbiology 2009, 9:25 (2 February 2009)

Software   Open Access

ArrayIDer: automated structural re-annotation pipeline for DNA microarrays

Bart HJ van den Berg, Jay H Konieczka, Fiona M McCarthy, Shane C Burgess BMC Bioinformatics 2009, 10:30 (23 January 2009)

Research article   Open Access

A Drosophila systems model of pentylenetetrazole induced locomotor plasticity responsive to antiepileptic drugs

Farhan Mohammad, Priyanka Singh, Abhay Sharma BMC Systems Biology 2009, 3:11 (21 January 2009)

Research article   Open Access Highly Accessed

Microarray and cDNA sequence analysis of transcription during nerve-dependent limb regeneration

James R Monaghan, Leonard G Epp, Srikrishna Putta, Robert B Page, John A Walker, Chris K Beachy, Wei Zhu, Gerald M Pao, Inder M Verma, Tony Hunter, Susan V Bryant, David M Gardiner, Tim T Harkins, S Randal Voss BMC Biology 2009, 7:1 (13 January 2009)

Following amputation, transcription is initially similar in innervated and denervated axolotl limbs, but without nerves there is a lack of cell proliferation and protracted wound healing takes place instead of regeneration.

Research article   Open Access Highly Accessed

Reconstruction and functional analysis of altered molecular pathways in human atherosclerotic arteries

Stefano Cagnin, Michele Biscuola, Cristina Patuzzo, Elisabetta Trabetti, Alessandra Pasquali, Paolo Laveder, Giuseppe Faggian, Mauro Iafrancesco, Alessandro Mazzucco, Pier Franco Pignatti, Gerolamo Lanfranchi BMC Genomics 2009, 10:13 (9 January 2009)

Research   Open Access Highly Accessed

Studying alternative splicing regulatory networks through partial correlation analysis

Liang Chen, Sika Zheng Genome Biology 2009, 10:R3 (9 January 2009)

The identification of links between exons and their regulators or targets and between co-spliced exons in human, mouse and rat provides novel insights into the alternative splicing regulatory network.

Software   Open Access

ContDist: a tool for the analysis of quantitative gene and promoter properties

Michael Hackenberg, Gorka Lasso, Rune Matthiesen BMC Bioinformatics 2009, 10:7 (7 January 2009)

Research article   Open Access

Interactions among type I and type II interferon, tumor necrosis factor, and β-estradiol in the regulation of immune response-related gene expressions in systemic lupus erythematosus

Hooi-Ming Lee, Toru Mima, Hidehiko Sugino, Chieko Aoki, Yasuo Adachi, Naoko Yoshio-Hoshino, Kenichi Matsubara, Norihiro Nishimoto Arthritis Research & Therapy 2009, 11:R1 (3 January 2009)

Software   Open Access Highly Accessed

WGCNA: an R package for weighted correlation network analysis

Peter Langfelder, Steve Horvath BMC Bioinformatics 2008, 9:559 (29 December 2008)

Research article   Open Access

Monocytes of patients with familial hypercholesterolemia show alterations in cholesterol metabolism

Sandy Mosig, Knut Rennert, Petra Büttner, Siegfried Krause, Dieter Lütjohann, Muhidien Soufi, Regine Heller, Harald Funke BMC Medical Genomics 2008, 1:60 (28 November 2008)

Research article   Open Access

Transcriptional response of rat frontal cortex following acute In Vivo exposure to the pyrethroid insecticides permethrin and deltamethrin

Joshua A Harrill, Zhen Li, Fred A Wright, Nicholas M Radio, William R Mundy, Rogelio Tornero-Velez, Kevin M Crofton BMC Genomics 2008, 9:546 (18 November 2008)

Short Report   Open Access

Global gene expression profiling of oral cavity cancers suggests molecular heterogeneity within anatomic subsites

Patricia Severino, Adriana M Alvares, Pedro Michaluart, Oswaldo K Okamoto, Fabio D Nunes, Carlos A Moreira-Filho, Eloiza H Tajara, BMC Research Notes 2008, 1:113 (13 November 2008)

Research article   Open Access

Putative psychosis genes in the prefrontal cortex: combined analysis of gene expression microarrays

Kwang Choi, Michael Elashoff, Brandon W Higgs, Jonathan Song, Sanghyeon Kim, Sarven Sabunciyan, Suad Diglisic, Robert H Yolken, Michael B Knable, E Fuller Torrey, Maree J Webster BMC Psychiatry 2008, 8:87 (7 November 2008)

Research article   Open Access

Gene expression profiling in chicken heterophils with Salmonella enteritidis stimulation using a chicken 44 K Agilent microarray

Hsin-I Chiang, Christina L Swaggerty, Michael H Kogut, Scot E Dowd, Xianyao Li, Igal Y Pevzner, Huaijun Zhou BMC Genomics 2008, 9:526 (6 November 2008)

Method   Open Access Highly Accessed

Boolean implication networks derived from large scale, whole genome microarray datasets

Debashis Sahoo, David L Dill, Andrew J Gentles, Robert Tibshirani, Sylvia K Plevritis Genome Biology 2008, 9:R157 (30 October 2008)

A method for analysis of microarray data is presented that extracts statistically significant Boolean implication relationships between pairs of genes.

Research article   Open Access

Transcriptional response of Mexican axolotls to Ambystoma tigrinum virus (ATV) infection

Jennifer D Cotter, Andrew Storfer, Robert B Page, Christopher K Beachy, S Randal Voss BMC Genomics 2008, 9:493 (20 October 2008)

Research article   Open Access

Mutant huntingtin activates Nrf2-responsive genes and impairs dopamine synthesis in a PC12 model of Huntington's disease

Willeke MC van Roon-Mom, Barry A Pepers, Peter AC 't Hoen, Carola ACM Verwijmeren, Johan T den Dunnen, Josephine C Dorsman, GertJan B van Ommen BMC Molecular Biology 2008, 9:84 (9 October 2008)

Research   Open Access Highly Accessed

Variations in the transcriptome of Alzheimer's disease reveal molecular networks involved in cardiovascular diseases

Monika Ray, Jianhua Ruan, Weixiong Zhang Genome Biology 2008, 9:R148 (8 October 2008)

Analysis of microarray data reveals extensive links between Alzheimer’s disease and cardiovascular diseases.

Research article   Open Access Highly Accessed

Maternal Oct-4 is a potential key regulator of the developmental competence of mouse oocytes

Maurizio Zuccotti, Valeria Merico, Lucia Sacchi, Michele Bellone, Thore C Brink, Riccardo Bellazzi, Mario Stefanelli, Carlo Redi, Silvia Garagna, James Adjaye BMC Developmental Biology 2008, 8:97 (6 October 2008)

Research article   Open Access Highly Accessed

Regulatory subunits of PKA define an axis of cellular proliferation/differentiation in ovarian cancer cells

Chris Cheadle, Maria Nesterova, Tonya Watkins, Kathleen C Barnes, John C Hall, Antony Rosen, Kevin G Becker, Yoon S Cho-Chung BMC Medical Genomics 2008, 1:43 (26 September 2008)

Overexpression of the regulatory subunit of cAMP-dependent protein kinase (PKA) in ovarian cancer cells causes hyperproliferation for the RI isoform and differentiation for RII, suggesting that PKA may be pivotal in disease progression.

Software   Open Access Highly Accessed

Presenting and exploring biological pathways with PathVisio

Martijn P van Iersel, Thomas Kelder, Alexander R Pico, Kristina Hanspers, Susan Coort, Bruce R Conklin, Chris Evelo BMC Bioinformatics 2008, 9:399 (25 September 2008)

Research article   Open Access Highly Accessed

Different gene-expression profiles for the poorly differentiated carcinoma and the highly differentiated papillary adenocarcinoma in mammary glands support distinct metabolic pathways

Tali Eilon, Itamar Barash BMC Cancer 2008, 8:270 (24 September 2008)

Method   Open Access Highly Accessed

Systematic bioinformatic analysis of expression levels of 17,330 human genes across 9,783 samples from 175 types of healthy and pathological tissues

Sami Kilpinen, Reija Autio, Kalle Ojala, Kristiina Iljin, Elmar Bucher, Henri Sara, Tommi Pisto, Matti Saarela, Rolf I Skotheim, Mari Björkman, John-Patrick Mpindi, Saija Haapa-Paananen, Paula Vainio, Henrik Edgren, Maija Wolf, Jaakko Astola, Matthias Nees, Sampsa Hautaniemi, Olli Kallioniemi Genome Biology 2008, 9:R139 (19 September 2008)

A method for the comparison of mRNA expression levels of most human genes across gene expression array experiments, and a database of the results, are presented.

Database   Open Access

SQUAT: A web tool to mine human, murine and avian SAGE data

Johan Leyritz, Stéphane Schicklin, Sylvain Blachon, Céline Keime, Céline Robardet, Jean-François Boulicaut, Jérémy Besson, Ruggero G Pensa, Olivier Gandrillon BMC Bioinformatics 2008, 9:378 (18 September 2008)

Methodology article   Open Access

Combining Shapley value and statistics to the analysis of gene expression data in children exposed to air pollution

Stefano Moretti, Danitsja van Leeuwen, Hans Gmuender, Stefano Bonassi, Joost van Delft, Jos Kleinjans, Fioravante Patrone, Domenico Merlo BMC Bioinformatics 2008, 9:361 (2 September 2008)

Proceedings   Open Access

From microarray to biology: an integrated experimental, statistical and in silico analysis of how the extracellular matrix modulates the phenotype of cancer cells

Mikhail G Dozmorov, Kimberly D Kyker, Paul J Hauser, Ricardo Saban, David D Buethe, Igor Dozmorov, Michael B Centola, Daniel J Culkin, Robert E Hurst BMC Bioinformatics 2008, 9(Suppl 9):S4 (12 August 2008)

Research article   Open Access Highly Accessed

Constructing disease-specific gene networks using pair-wise relevance metric: Application to colon cancer identifies interleukin 8, desmin and enolase 1 as the central elements

Wei Jiang, Xia Li, Shaoqi Rao, Lihong Wang, Lei Du, Chuanxing Li, Chao Wu, Hongzhi Wang, Yadong Wang, Baofeng Yang BMC Systems Biology 2008, 2:72 (10 August 2008)

Research   Open Access

Modeling gene-by-environment interaction in comorbid depression with alcohol use disorders via an integrated bioinformatics approach

Richard C McEachin, Benjamin J Keller, Erika FH Saunders, Melvin G McInnis BioData Mining 2008, 1:2 (17 July 2008)

Research article   Open Access Highly Accessed

Genes responsive to both oxidant stress and loss of estrogen receptor function identify a poor prognosis group of estrogen receptor positive primary breast cancers

Christina Yau, Christopher C Benz Breast Cancer Research 2008, 10:R61 (17 July 2008)

An investigation into the effect of oxidative stress on estrogen and estrogen receptor-regulated gene expression identified a subset of oxidant-sensitive genes associated with poor prognosis in ER+ primary breast cancer.

Research article   Open Access Highly Accessed

Evolutionary conservation of zinc finger transcription factor binding sites in promoters of genes co-expressed with WT1 in prostate cancer

Kurtis Eisermann, Sunpreet Tandon, Anton Bazarov, Adina Brett, Gail Fraizer, Helen Piontkivska BMC Genomics 2008, 9:337 (16 July 2008)

Research article   Open Access Highly Accessed

Meta-analysis of nasopharyngeal carcinoma microarray data explores mechanism of EBV-regulated neoplastic transformation

Xia Chen, Shuang Liang, WenLing Zheng, ZhiJun Liao, Tao Shang, WenLi Ma BMC Genomics 2008, 9:322 (7 July 2008)

Research article   Open Access

Association between PPARGC1A polymorphisms and the occurrence of nonalcoholic fatty liver disease (NAFLD)

Masato Yoneda, Kikuko Hotta, Yuichi Nozaki, Hiroki Endo, Takashi Uchiyama, Hironori Mawatari, Hiroshi Iida, Shingo Kato, Kunihiro Hosono, Koji Fujita, Kyoko Yoneda, Hirokazu Takahashi, Hiroyuki Kirikoshi, Noritoshi Kobayashi, Masahiko Inamori, Yasunobu Abe, Kensuke Kubota, Satoru Saito, Shiro Maeyama, Koichiro Wada, Atsushi Nakajima BMC Gastroenterology 2008, 8:27 (27 June 2008)

Methodology article   Open Access Highly Accessed

Literature-aided meta-analysis of microarray data: a compendium study on muscle development and disease

Rob Jelier, Peter AC 't Hoen, Ellen Sterrenburg, Johan T den Dunnen, Gert-Jan B van Ommen, Jan A Kors, Barend Mons BMC Bioinformatics 2008, 9:291 (24 June 2008)

Methodology article   Open Access Highly Accessed

Stability of gene contributions and identification of outliers in multivariate analysis of microarray data

Florent Baty, Daniel Jaeger, Frank Preiswerk, Martin M Schumacher, Martin H Brutsche BMC Bioinformatics 2008, 9:289 (20 June 2008)

Research article   Open Access Highly Accessed

Sources of variation in baseline gene expression levels from toxicogenomics study control animals across multiple laboratories

Michael J Boedigheimer, Russell D Wolfinger, Michael B Bass, Pierre R Bushel, Jeff W Chou, Matthew Cooper, J Christopher Corton, Jennifer Fostel, Susan Hester, Janice S Lee, Fenglong Liu, Jie Liu, Hui-Rong Qian, John Quackenbush, Syril Pettit, Karol L Thompson BMC Genomics 2008, 9:285 (12 June 2008)

An inter-laboratory meta-analysis of more than 500 microarrays from the liver and kidney of control rats defined key sources of variability in control animals and will aid in the efficient design of future toxicogenomics experiments.

Research   Open Access

Identification of differentially expressed proteins in spontaneous thymic lymphomas from knockout mice with deletion of p53

Bent Honoré, Søren Buus, Mogens H Claësson Proteome Science 2008, 6:18 (10 June 2008)

Research article   Open Access Highly Accessed

Functional characterization of endogenous siRNA target genes in Caenorhabditis elegans

Suvi Asikainen, Liisa Heikkinen, Garry Wong, Markus Storvik BMC Genomics 2008, 9:270 (3 June 2008)

Research article   Open Access Highly Accessed

'Systems toxicology' approach identifies coordinated metabolic responses to copper in a terrestrial non-model invertebrate, the earthworm Lumbricus rubellus

Jacob G Bundy, Jasmin K Sidhu, Faisal Rana, David J Spurgeon, Claus Svendsen, Jodie F Wren, Stephen R Stürzenbaum, A John Morgan, Peter Kille BMC Biology 2008, 6:25 (3 June 2008)

The toxic effects of chemical contaminants like copper on a key indicator organism, the earthworm, can be monitored by combining metabolomics and transcriptomics, a systems ecotoxicology approach that provides detailed molecular information about adaptation to soil pollutants.

Research   Open Access

On the necessity of different statistical treatment for Illumina BeadChip and Affymetrix GeneChip data and its significance for biological interpretation

Wing-Cheong Wong, Marie Loh, Frank Eisenhaber Biology Direct 2008, 3:23 (3 June 2008)

Research article   Open Access

Divergence of canonical danger signals: The genome-level expression patterns of human mononuclear cells subjected to heat shock or lipopolysaccharide

Hector R Wong, Kelli Odoms, Bhuvaneswari Sakthivel BMC Immunology 2008, 9:24 (30 May 2008)

Research   Open Access

Improving the power for detecting overlapping genes from multiple DNA microarray-derived gene lists

Xutao Deng, Jun Xu, Charles Wang BMC Bioinformatics 2008, 9(Suppl 6):S14 (28 May 2008)

Research article   Open Access

Genomic analysis of post-mating changes in the honey bee queen (Apis mellifera)

Sarah D Kocher, Freddie-Jeanne Richard, David R Tarpy, Christina M Grozinger BMC Genomics 2008, 9:232 (19 May 2008)

Research article   Open Access Highly Accessed

In vivo gene expression profiling of human intestinal epithelial cells: analysis by laser microdissection of formalin fixed tissues

Michael D George, Jan Wehkamp, Robert J Kays, Christian M Leutenegger, Sadiah Sabir, Irina Grishina, Satya Dandekar, Charles L Bevins BMC Genomics 2008, 9:209 (5 May 2008)

Research article   Open Access

Transcriptome analysis identifies pathways associated with enhanced maternal performance in QSi5 mice

Palaniappan Ramanathan, Ian C Martin, Margaret Gardiner-Garden, Peter C Thomson, Rosanne M Taylor, Christopher J Ormandy, Christopher Moran, Peter Williamson BMC Genomics 2008, 9:197 (29 April 2008)

Research   Open Access Highly Accessed

Histone deacetylase inhibition accelerates the early events of stem cell differentiation: transcriptomic and epigenetic analysis

Efthimia Karantzali, Herbert Schulz, Oliver Hummel, Norbert Hubner, AK Hatzopoulos, Androniki Kretsovali Genome Biology 2008, 9:R65 (4 April 2008)

A gene profiling study of mouse embryonic stem cells treated with the histone deacetylase inhibitor trichostatin A shows that inhibition of histone deacetylases accelerates the early events of differentiation, by regulating the expression of pluripotency- and differentiation-associated in an opposite manner.

Research   Open Access Highly Accessed

A sequence-based survey of the complex structural organization of tumor genomes

Benjamin J Raphael, Stanislav Volik, Peng Yu, Chunxiao Wu, Guiqing Huang, Elena V Linardopoulou, Barbara J Trask, Frederic Waldman, Joseph Costello, Kenneth J Pienta, Gordon B Mills, Krystyna Bajsarowicz, Yasuko Kobayashi, Shivaranjani Sridharan, Pamela L Paris, Quanzhou Tao, Sarah J Aerni, Raymond P Brown, Ali Bashir, Joe W Gray, Jan-Fang Cheng, Pieter de Jong, Mikhail Nefedov, Thomas Ried, Hesed M Padilla-Nash, Colin C Collins Genome Biology 2008, 9:R59 (25 March 2008)

Tumors and cancer cell lines were surveyed with end-sequencing profiling, yielding the largest available collection of sequence-ready tumor genome breakpoints and providing evidence that some rearrangements may be recurrent.

Database   Open Access

MADIBA: A web server toolkit for biological interpretation of Plasmodium and plant gene clusters

Philip J Law, Clotilde Claudel-Renard, Fourie Joubert, Abraham I Louw, Dave K Berger BMC Genomics 2008, 9:105 (28 February 2008)

Research article   Open Access Highly Accessed

Merging microarray data from separate breast cancer studies provides a robust prognostic test

Lei Xu, Aik Tan, Raimond L Winslow, Donald Geman BMC Bioinformatics 2008, 9:125 (27 February 2008)

Methodology article   Open Access

Simple integrative preprocessing preserves what is shared in data sources

Abhishek Tripathi, Arto Klami, Samuel Kaski BMC Bioinformatics 2008, 9:111 (21 February 2008)

Research article   Open Access

Effect of thyroid hormone concentration on the transcriptional response underlying induced metamorphosis in the Mexican axolotl (Ambystoma)

Robert B Page, Stephen R Voss, Amy K Samuels, Jeramiah J Smith, Srikrishna Putta, Christopher K Beachy BMC Genomics 2008, 9:78 (11 February 2008)

Research article   Open Access Highly Accessed

Analysis of the retinal gene expression profile after hypoxic preconditioning identifies candidate genes for neuroprotection

Markus Thiersch, Wolfgang Raffelsberger, Rico Frigg, Marijana Samardzija, Andreas Wenzel, Olivier Poch, Christian Grimm BMC Genomics 2008, 9:73 (8 February 2008)

Research article   Open Access Highly Accessed

Characterization of a newly developed chicken 44K Agilent microarray

Xianyao Li, Hsin-I Chiang, James Zhu, Scot E Dowd, Huaijun Zhou BMC Genomics 2008, 9:60 (31 January 2008)

Research article   Open Access Highly Accessed

Meta-analysis of breast cancer microarray studies in conjunction with conserved cis-elements suggest patterns for coordinate regulation

David D Smith, Pål Sætrom, Ola Snøve, Cathryn Lundberg, Guillermo E Rivas, Carlotta Glackin, Garrett P Larson BMC Bioinformatics 2008, 9:63 (28 January 2008)

Research   Open Access

Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling

Scott H Robbins, Thierry Walzer, Doulaye Dembélé, Christelle Thibault, Axel Defays, Gilles Bessou, Huichun Xu, Eric Vivier, MacLean Sellars, Philippe Pierre, Franck R Sharp, Susan Chan, Philippe Kastner, Marc Dalod Genome Biology 2008, 9:R17 (24 January 2008)

Genome-wide expression profiling of mouse and human leukocytes reveal conserved transcriptional programs of plasmacytoid or conventional dendritic cell subsets.

Research article   Open Access

Coordinated evolution of co-expressed gene clusters in the Drosophila transcriptome

Jason G Mezey, Sergey V Nuzhdin, Fangfei Ye, Corbin D Jones BMC Evolutionary Biology 2008, 8:2 (7 January 2008)

Method   Open Access Highly Accessed

Broad network-based predictability of Saccharomyces cerevisiae gene loss-of-function phenotypes

Kriston L McGary, Insuk Lee, Edward M Marcotte Genome Biology 2007, 8:R258 (5 December 2007)

Loss-of-function phenotypes of yeast genes can be predicted from the loss-of-function phenotypes of their neighbours in functional gene networks. This could potentially be applied to the prediction of human disease genes.

Method   Open Access Highly Accessed

Prediction of synergistic transcription factors by function conservation

Zihua Hu, Boyu Hu, James F Collins Genome Biology 2007, 8:R257 (5 December 2007)

A new strategy is proposed for identifying synergistic transcription factors by function conservation, leading to the identification of 51 homotypic transcription-factor combinations.

Research   Open Access

Genome-wide expression profiling and bioinformatics analysis of diurnally regulated genes in the mouse prefrontal cortex

Shuzhang Yang, Kai Wang, Otto Valladares, Sridhar Hannenhalli, Maja Bucan Genome Biology 2007, 8:R247 (20 November 2007)

Microarray analysis shows that approximately 10% of transcripts in the mouse prefrontal cortex have diurnally regulated expression patterns.

Software   Open Access Highly Accessed

The Firegoose: two-way integration of diverse data from different bioinformatics web resources with desktop applications

J Christopher Bare, Paul T Shannon, Amy K Schmid, Nitin S Baliga BMC Bioinformatics 2007, 8:456 (19 November 2007)

Research article   Open Access Highly Accessed

Suicide candidate genes associated with bipolar disorder and schizophrenia: An exploratory gene expression profiling analysis of post-mortem prefrontal cortex

Sanghyeon Kim, Kwang-Ho Choi, Ali Baykiz, Howard K Gershenfeld BMC Genomics 2007, 8:413 (12 November 2007)

Database   Open Access Highly Accessed

DAVID Knowledgebase: a gene-centered database integrating heterogeneous gene annotation resources to facilitate high-throughput gene functional analysis

Brad T Sherman, Da Huang, Qina Tan, Yongjian Guo, Stephan Bour, David Liu, Robert Stephens, Michael W Baseler, H Clifford Lane, Richard A Lempicki BMC Bioinformatics 2007, 8:426 (2 November 2007)

Research article   Open Access

Large-scale analysis by SAGE reveals new mechanisms of v-erbA oncogene action

Corinne Bresson, Celine Keime, Claudine Faure, Yann Letrillard, Maud Barbado, Sandra Sanfilippo, Najate Benhra, Olivier Gandrillon, Sandrine Gonin-Giraud BMC Genomics 2007, 8:390 (26 October 2007)

Methodology article   Open Access

Computational selection and prioritization of candidate genes for Fetal Alcohol Syndrome

Zané Lombard, Nicki Tiffin, Oliver Hofmann, Vladimir B Bajic, Winston Hide, Michèle Ramsay BMC Genomics 2007, 8:389 (25 October 2007)

Software   Open Access

BMDExpress: a software tool for the benchmark dose analyses of genomic data

Longlong Yang, Bruce C Allen, Russell S Thomas BMC Genomics 2007, 8:387 (25 October 2007)

Method   Open Access

Simplified ontologies allowing comparison of developmental mammalian gene expression

Adele Kruger, Oliver Hofmann, Piero Carninci, Yoshihide Hayashizaki, Winston Hide Genome Biology 2007, 8:R229 (25 October 2007)

The Developmental eVOC ontologies presented are simplified orthogonal ontologies describing the temporal and spatial distribution of developmental human and mouse anatomy.

Research   Open Access

Gene expression profiling of Hfe-/- liver and duodenum in mouse strains with differing susceptibilities to iron loading: identification of transcriptional regulatory targets of Hfe and potential hemochromatosis modifiers

Hélène Coppin, Valérie Darnaud, Léon Kautz, Delphine Meynard, Marc Aubry, Jean Mosser, Maria Martinez, Marie-Paule Roth Genome Biology 2007, 8:R221 (18 October 2007)

Gene expression profiling using microarrays of Hfe-/- liver and duodenum in mouse strains with differing susceptibilities to iron loading allowed the identification of transcriptional targets of the hemochromatosis-associated gene Hfe.

Research article   Open Access

Improved human disease candidate gene prioritization using mouse phenotype

Jing Chen, Huan Xu, Bruce J Aronow, Anil G Jegga BMC Bioinformatics 2007, 8:392 (16 October 2007)

Research article   Open Access

Characterization of oligopeptide patterns in large protein sets

Anders Bresell, Bengt Persson BMC Genomics 2007, 8:346 (1 October 2007)

Methodology article   Open Access

Linking microarray reporters with protein functions

Stan Gaj, Arie van Erk, Rachel IM van Haaften, Chris TA Evelo BMC Bioinformatics 2007, 8:360 (26 September 2007)

Research article   Open Access Highly Accessed

Integrated analysis of independent gene expression microarray datasets improves the predictability of breast cancer outcome

Zhe Zhang, Dechang Chen, David A Fenstermacher BMC Genomics 2007, 8:331 (20 September 2007)

Brief reports   Open Access

OCPAT: an online codon-preserved alignment tool for evolutionary genomic analysis of protein coding sequences

Guozhen Liu, Monica Uddin, Munirul Islam, Morris Goodman, Lawrence I Grossman, Roberto Romero, Derek E Wildman Source Code for Biology and Medicine 2007, 2:5 (18 September 2007)

Research article   Open Access

Characterization of the effect of sample quality on high density oligonucleotide microarray data using progressively degraded rat liver RNA

Karol L Thompson, P Scott Pine, Barry A Rosenzweig, Yaron Turpaz, Jacques Retief BMC Biotechnology 2007, 7:57 (13 September 2007)

Methodology article   Open Access Highly Accessed

EDISA: extracting biclusters from multiple time-series of gene expression profiles

Jochen Supper, Martin Strauch, Dierk Wanke, Klaus Harter, Andreas Zell BMC Bioinformatics 2007, 8:334 (12 September 2007)

Primary research   Open Access Highly Accessed

Modulation by decitabine of gene expression and growth of osteosarcoma U2OS cells in vitro and in xenografts: Identification of apoptotic genes as targets for demethylation

Khaldoun Al-Romaih, Gino R Somers, Jane Bayani, Simon Hughes, Mona Prasad, Jean-Claude Cutz, Hui Xue, Maria Zielenska, Yuzhuo Wang, Jeremy A Squire Cancer Cell International 2007, 7:14 (10 September 2007)

Software   Open Access Highly Accessed

The DAVID Gene Functional Classification Tool: a novel biological module-centric algorithm to functionally analyze large gene lists

Da Huang, Brad T Sherman, Qina Tan, Jack R Collins, W Gregory Alvord, Jean Roayaei, Robert Stephens, Michael W Baseler, H Clifford Lane, Richard A Lempicki Genome Biology 2007, 8:R183 (4 September 2007)

The DAVID gene functional classification tool uses a novel fuzzy clustering algorithm to condense a list of genes or associated biological terms into organized classes of related genes or biology, called biological modules.

Research   Open Access Highly Accessed

The roles of binding site arrangement and combinatorial targeting in microRNA repression of gene expression

Lawrence S Hon, Zemin Zhang Genome Biology 2007, 8:R166 (14 August 2007)

A genome wide analysis of factors affecting repression of mRNAs by microRNAs reveals roles for 3'UTR length, the number of target sites on the mRNA and the distance between pairs of binding sites.

Methodology article   Open Access

Post hoc pattern matching: assigning significance to statistically defined expression patterns in single channel microarray data

Randall Hulshizer, Eric M Blalock BMC Bioinformatics 2007, 8:240 (5 July 2007)

Research   Open Access

Morphine effects on striatal transcriptome in mice

Michal Korostynski, Marcin Piechota, Dorota Kaminska, Wojciech Solecki, Ryszard Przewlocki Genome Biology 2007, 8:R128 (28 June 2007)

Global transcriptional analysis of mouse striata following acute and chronic exposure to morphine reveals multiple physiological factors which may affect opioid-related phenotypes and implicates a number of gene networks, including glucocorticoid receptor regulated genes, in the response to this opioid.

Primary research   Open Access Highly Accessed

Common molecular pathways involved in human CD133+/CD34+ progenitor cell expansion and cancer

Oswaldo Okamoto, Ana Carolina SR Carvalho, Luciana C Marti, Ricardo Z Vêncio, Carlos A Moreira-Filho Cancer Cell International 2007, 7:11 (8 June 2007)

Research   Open Access Highly Accessed

A functional map of NFκB signaling identifies novel modulators and multiple system controls

Thomas A Halsey, Longlong Yang, John R Walker, John B Hogenesch, Russell S Thomas Genome Biology 2007, 8:R104 (6 June 2007)

Using cell-based genomic screens and functional assays, positive and negative modulators of NFκB signaling were identified and mapped onto the known NFκB signaling cascade.

Research article   Open Access Highly Accessed

Understanding network concepts in modules

Jun Dong, Steve Horvath BMC Systems Biology 2007, 1:24 (4 June 2007)

Software   Open Access Highly Accessed

Genome Expression Pathway Analysis Tool – Analysis and visualization of microarray gene expression data under genomic, proteomic and metabolic context

Markus Weniger, Julia C Engelmann, Jörg Schultz BMC Bioinformatics 2007, 8:179 (2 June 2007)

Research article   Open Access Highly Accessed

Silencing of core transcription factors in human EC cells highlights the importance of autocrine FGF signaling for self-renewal

Boris Greber, Hans Lehrach, James Adjaye BMC Developmental Biology 2007, 7:46 (16 May 2007)

Method   Open Access

Revealing signaling pathway deregulation by using gene expression signatures and regulatory motif analysis

Yingchun Liu, Markus Ringnér Genome Biology 2007, 8:R77 (11 May 2007)

A strategy for identifying cell signaling pathways whose deregulation result in an observed expression signature is presented.

Research   Open Access Highly Accessed

Genomic analysis of human lung fibroblasts exposed to vanadium pentoxide to identify candidate genes for occupational bronchitis

Jennifer L Ingram, Aurita Antao-Menezes, Elizabeth A Turpin, Duncan G Wallace, James B Mangum, Linda J Pluta, Russell S Thomas, James C Bonner Respiratory Research 2007, 8:34 (25 April 2007)

Research article   Open Access Highly Accessed

Expression profiling of genes regulated by TGF-beta: Differential regulation in normal and tumour cells

Prathibha Ranganathan, Animesh Agrawal, Raghu Bhushan, Aravinda K Chavalmane, Ravi Kalathur, Takashi Takahashi, Paturu Kondaiah BMC Genomics 2007, 8:98 (11 April 2007)

Research   Open Access

Global transcriptome analysis of murine embryonic stem cell-derived cardiomyocytes

Michael Doss, Johannes Winkler, Shuhua Chen, Rita Hippler-Altenburg, Isaia Sotiriadou, Marcel Halbach, Kurt Pfannkuche, Huamin Liang, Herbert Schulz, Oliver Hummel, Norbert Hübner, Ruth Rottscheidt, Jürgen Hescheler, Agapios Sachinidis Genome Biology 2007, 8:R56 (11 April 2007)