Ouput of DomainCharts. A) Visualization chart showing the distribution of 402 genes among protein domains. The parameters were set to a minimum hit threshold of 4 and output was sorted by hit count. Similar to the output of GoCharts and KeggCharts, blue bars represent the number of genes containing that particular domain. Selecting a blue bar opens an HTML table showing the LocusLink, Gene Name, Current Classification, and Other Classification data for the genes in that pathway (data not shown). B) Selecting the domain name 'IL8' in Figure 6A that contains 6 differentially expressed genes brings the user to a new page containing the output from the Conserved Domain Database (CDD) of NCBI, which provides detailed information about the IL8 domain including structural information, multiple sequence alignments, and descriptive information about the domain and the proteins that possess it.
Dennis et al. Genome Biology 2003 4:P3 doi:10.1186/gb-2003-4-5-p3