Combined histomorphometric and gene-expression profiling applied to toxicology
1 Tissue Informatics Inc., 711 Bingham Street, Suite 200, Pittsburgh, PA 15203, USA
2 InforMax - Invitrogen Life Science Software, 7305 Executive Way, Frederick, MD 21704, USA
3 Motorola Life Sciences, 4088 Commercial Avenue, Northbrook, IL 60062, USA
4 Amersham Biosciences, 3200 West Germann Rd., Chandler, AZ 7285248, USA
Genome Biology 2003, 4:R32 doi:10.1186/gb-2003-4-5-r32Published: 30 April 2003
We have developed a unique methodology for the combined analysis of histomorphometric and gene-expression profiles amenable to intensive data mining and multisample comparison for a comprehensive approach to toxicology. This hybrid technology, termed extensible morphometric relational gene-expression analysis (EMeRGE), is applied in a toxicological study of time-varied vehicle- and carbon-tetrachloride (CCl4)-treated rats, and demonstrates correlations between specific genes and tissue structures that can augment interpretation of biological observations and diagnosis.