Open Access Software

GeneHopper: a web-based search engine to link gene-expression platforms through GenBank accession numbers

B Anders T Svensson, Arja J Kreeft, Gert-Jan B van Ommen, Johan T den Dunnen and Judith M Boer*

Author Affiliations

Center for Human and Clinical Genetics/Leiden Genome Technology Center, Leiden University Medical Center, Wassenaarseweg 72, 2333 AL Leiden, The Netherlands

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Genome Biology 2003, 4:R35 doi:10.1186/gb-2003-4-5-r35

Published: 25 April 2003

Abstract

Global gene-expression analysis is carried out using different technologies that are either array- or sequence-tag-based. To compare experiments that are performed on these different platforms, array probes and sequence tags need to be linked. An additional challenge is cross-referencing between species, to compare human profiles with those obtained in a mouse model, for example. We have developed the web-based search engine GeneHopper to link different expression resources based on UniGene clusters and HomoloGene orthologs databases of the National Center for Biotechnology Information (NCBI).