Review
Matrix metalloproteinases: old dogs with new tricks
-
* Corresponding author: Suneel S Apte aptes@bme.ri.ccf.org
Department of Biomedical Engineering, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Genome Biology 2003, 4:216 doi:10.1186/gb-2003-4-6-216
Published: 29 May 2003Abstract
The matrix metalloproteinase family in humans comprises 23 enzymes, which are involved in many biological processes and diseases. It was previously thought that these enzymes acted only to degrade components of the extracellular matrix, but this view has changed with the discovery that non-extracellular-matrix molecules are also substrates.