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Differential gene-expression patterns in genital fibroblasts of normal males and 46,XY females with androgen insensitivity syndrome: evidence for early programming involving the androgen receptor

Paul-Martin Holterhus*, Olaf Hiort, Janos Demeter, Patrick O Brown* and James D Brooks*

Genome Biology 2003, 4:R37 doi:10.1186/gb-2003-4-6-r37

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BioMed Central: 2 citations

Research article   Open Access

Disorders of sex development expose transcriptional autonomy of genetic sex and androgen-programmed hormonal sex in human blood leukocytes

Paul-Martin Holterhus, Jan-Hendrik Bebermeier, Ralf Werner, Janos Demeter, Annette Richter-Unruh, Gunnar Cario, Mahesh Appari, Reiner Siebert, Felix Riepe, James D Brooks, Olaf Hiort BMC Genomics 2009, 10:292 (1 July 2009)

Abstract | Full text | PDF | PubMed

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Intrinsic androgen-dependent gene expression patterns revealed by comparison of genital fibroblasts from normal males and individuals with complete and partial androgen insensitivity syndrome

Paul-Martin Holterhus, Uta Deppe, Ralf Werner, Annette Richter-Unruh, Jan-Hendrik Bebermeier, Lutz Wünsch, Susanne Krege, Hans-Udo Schweikert, Janos Demeter, Felix Riepe, Olaf Hiort, James D Brooks BMC Genomics 2007, 8:376 (18 October 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | Editor’s summary

Genital fibroblasts from XY females with complete androgen insensitivity syndrome have extensive differences in gene expression compared to those from XY males, which may suggest candidate genes for androgen-dependent aspects of genital differentiation.

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