Correspondence
EST analyses predict the existence of a population of chimeric microRNA precursor-mRNA transcripts expressed in normal human and mouse tissues
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Correspondence: Neil R Smalheiser smalheiser@psych.uic.edu
Department of Psychiatry, University of Illinois at Chicago, 1601 W. Taylor Street MC 912, Chicago, IL 60612, USA
Genome Biology 2003, 4:403 doi:10.1186/gb-2003-4-7-403
Published: 18 June 2003Abstract
A significant population of expressed sequence tags (ESTs) encodes chimeric transcripts containing microRNA (miRNA) precursor sequences as well as pieces of adjacent mRNAs in sense orientation. These chimeric transcripts may potentially be involved in miRNA biosynthesis, and/or affect expression of adjacent mammalian mRNAs.