Genome Biology

official impact factor 6.89

Open Access

Phylogenetically and spatially conserved word pairs associated with gene-expression changes in yeasts

Derek Y Chiang, Alan M Moses, Manolis Kellis, Eric S Lander and Michael B Eisen*

Genome Biology 2003, 4:R43 doi:10.1186/gb-2003-4-7-r43

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BioMed Central: 11 citations

Software   Open Access Highly Accessed

ArrayPlex: distributed, interactive and programmatic access to genome sequence, annotation, ontology, and analytical toolsets

Patrick J Killion, Vishwanath R Iyer Genome Biology 2008, 9:R159 (12 November 2008)

ArrayPlex is a software package that centrally provides a large number of flexible toolsets useful for functional genomics.

Database   Open Access

A Caenorhabditis motif compendium for studying transcriptional gene regulation

Christoph Dieterich, Ralf J Sommer BMC Genomics 2008, 9:30 (23 January 2008)

Method   Open Access Highly Accessed

Prediction of synergistic transcription factors by function conservation

Zihua Hu, Boyu Hu, James F Collins Genome Biology 2007, 8:R257 (5 December 2007)

A new strategy is proposed for identifying synergistic transcription factors by function conservation, leading to the identification of 51 homotypic transcription-factor combinations.

Research article   Open Access

Flexible promoter architecture requirements for coactivator recruitment

Derek Y Chiang, David A Nix, Ryan K Shultzaberger, Audrey P Gasch, Michael B Eisen BMC Molecular Biology 2006, 7:16 (28 April 2006)

Software   Open Access

XcisClique: analysis of regulatory bicliques

Amrita Pati, Cecilia Vasquez-Robinet, Lenwood S Heath, Ruth Grene, TM Murali BMC Bioinformatics 2006, 7:218 (21 April 2006)

Methodology article   Open Access Highly Accessed

Genome-wide identification of the regulatory targets of a transcription factor using biochemical characterization and computational genomic analysis

Emmitt R Jolly, Chen-Shan Chin, Ira Herskowitz, Hao Li BMC Bioinformatics 2005, 6:275 (18 November 2005)

A new method combining biochemical characterisation with computational genomic analysis has been used successfully to identify targets of the yeast sporulation transcription factor, Ndt80.

Research article   Open Access

Ab initio identification of putative human transcription factor binding sites by comparative genomics

D CorĂ , C Herrmann, C Dieterich, F Di Cunto, P Provero, M Caselle BMC Bioinformatics 2005, 6:110 (2 May 2005)

Method   Open Access Highly Accessed

Fast and systematic genome-wide discovery of conserved regulatory elements using a non-alignment based approach

Olivier Elemento, Saeed Tavazoie Genome Biology 2005, 6:R18 (26 January 2005)

The authors describe a powerful approach for discovering globally conserved regulatory elements between two genomes that does not require alignments. Its application to pairs of yeasts, worm, flies and mammals, yields a large number of known and novel putative regulatory elements, many of which show surprising conservation across large phylogenetic distances.

Research   Open Access

Construction of predictive promoter models on the example of antibacterial response of human epithelial cells

Ekaterina Shelest, Edgar Wingender Theoretical Biology and Medical Modelling 2005, 2:2 (12 January 2005)

Method   Open Access Highly Accessed

MONKEY: identifying conserved transcription-factor binding sites in multiple alignments using a binding site-specific evolutionary model

Alan M Moses, Derek Y Chiang, Daniel A Pollard, Venky N Iyer, Michael B Eisen Genome Biology 2004, 5:R98 (30 November 2004)

MONKEY is a new method for identifying conserved transcription-factor binding sites from multiple-sequence alignments.

Minireview   Free

Rewiring the transcriptional regulatory circuits of cells

Devin R Scannell, Ken Wolfe Genome Biology 2004, 5:206 (29 January 2004)

New data from yeast species show that both changing the cis-acting DNA elements in promoters, and replacing the trans-acting regulatory proteins can regulate gene expression.