Table 1 |
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Top 30 genes showing higher expression in xenograft tumors over cultures for each cell line ranked by fold change |
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| Probe set |
Gene |
Gene product description |
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| Higher in U118 tumors over cultures (p < 0.01, fold change > 5) |
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| V00594_s_at |
MT2A |
Metallothionein 2a |
| M33552_at |
LSP1 |
Lymphocyte-specific protein 1 |
| U41518_at |
AQP1 |
Aquaporin 1 (channel-forming integral protein, 28 kD) |
| Z24680_at |
GARP |
Glycoprotein A repetitions predominant |
| J04599_at |
BGN |
Biglycan |
| J03278_at |
PDGFRB |
Platelet-derived growth factor receptor, beta polypeptide |
| M11718_at |
COL5A2 |
Collagen, type V, alpha 2 |
| L08096_s_at |
TNFSF7 |
Tumor necrosis factor (ligand) superfamily, member 7 |
| D87002_cds2_at |
POM121L1 |
Similar to rat integral membrane glycoprotein POM121 |
| HG2994-HT4850_s_at |
ELN |
Elastin (supravalvular aortic stenosis, Williams-Beuren syndrome) |
| Z74615_at |
COL1A1 |
Collagen, type I, alpha 1 |
| M57399_at |
PTN |
Pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1) |
| L07807_s_at |
DNM1 |
Dynamin 1 |
| Z74616_s_at |
COL1A2 |
Collagen, type I, alpha 2 |
| L38486_at |
MFAP4 |
Microfibrillar-associated protein 4 |
| X14885_rna1_s_at |
TGFB3 |
Transforming growth factor, beta 3 |
| U24488_s_at |
TNXB |
Tenascin XB |
| D86479_at |
AEBP1 |
AE-binding protein 1 |
| M80563_at |
S100A4 |
S100 calcium-binding protein A4 |
| M18533_at |
DMD |
Dystrophin (muscular dystrophy, Duchenne and Becker types |
| HG945-HT945_s_at |
ZNF9 |
Zinc finger protein 9 (a cellular retroviral nucleic acid binding protein) |
| M93221_at |
MRC1 |
Mannose receptor, C type 1 |
| D12485_at |
ENPP1 |
Ectonucleotide pyrophosphatase/phosphodiesterase 1 |
| HG1078-HT1078_at |
FLJ10254 |
Hypothetical protein FLJ10254 |
| HG2810-HT2921_at |
HOXA10 |
Homeo box A10 |
| M24351_cds3_s_at |
PTHLH |
Parathyroid hormone-like hormone |
| D13666_s_at |
OSF-2 |
Osteoblast specific factor 2 (fasciclin I-like) |
| Z37976_at |
LTBP2 |
Latent transforming growth factor beta binding protein 2 |
| M35878_at |
IGFBP3 |
Insulin-like growth factor binding protein 3 |
| X04412_at |
GSN |
Gelsolin (amyloidosis, Finnish type) |
| Higher in A549 tumors over cultures (p < 0.01, fold change > 10) |
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| Z19574_rna1_at |
KRT17 |
Keratin 17 |
| M29540_at |
CEACAM5 |
Carcinoembryonic antigen-related cell adhesion molecule 5 |
| M35252_at |
TM4SF3 |
Transmembrane 4 superfamily member 3 |
| HG371-HT26388_s_at |
MUC1 |
Mucin 1, transmembrane |
| X52003_at |
TFF1 |
Trefoil factor 1 (breast cancer, estrogen-inducible sequence expressed in) |
| U40434_at |
MSLN |
Mesothelin |
| Z48314_s_at |
MUC5AC |
Mucin 5, subtypes A and C, tracheobronchial/gastric |
| M57730_at |
EFNA1 |
Ephrin-A1 |
| L24203_at |
TRIM29 |
Tripartite motif-containing 29 |
| U17760_rna1_at |
LAMB3 |
Laminin, beta 3 (nicein (125 kD), kalinin (140 kD), BM600 (125 kD)) |
| U04313_at |
SERPINB5 |
Serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5 |
| J05068_at |
TCN1 |
Transcobalamin I (vitamin B12 binding protein, R binder family) |
| AB006781_s_at |
LGALS4 |
Lectin, galactoside-binding, soluble, 4 (galectin 4) |
| K01396_at |
SERPINA1 |
Serine (or cysteine) proteinase inhibitor, clade A), member 1 |
| M27436_s_at |
F3 |
Coagulation factor III (thromboplastin, tissue factor) |
| V01512_rna1_at |
FOS |
v-Fos FBJ murine osteosarcoma viral oncogene homolog |
| M18728_at |
CEACAM6 |
Carcinoembryonic antigen-related cell adhesion molecule 6 |
| HG2981-HT3127_s_at |
CD44 |
CD44 antigen (homing function and Indian blood group system) |
| U37283_at |
MAGP2 |
Microfibril-associated glycoprotein-2 |
| U78551_at |
MUC5B |
Mucin 5, subtype B, tracheobronchial |
| S77410_at |
AGTR1 |
Angiotensin receptor 1 |
| J04469_at |
CKMT1 |
Creatine kinase, mitochondrial 1 (ubiquitous) |
| S73591_at |
TXNIP |
Thioredoxin interacting protein |
| Y00318_at |
IF |
I factor (complement) |
| M35878_at |
IGFBP3 |
Insulin-like growth factor binding protein 3 |
| M34309_at |
ERBB3 |
v-Erb-b2 avian erythroblastic leukemia viral oncogene homolog 3 |
| M95787_at |
TAGLN |
Transgelin |
| L34155_at |
LAMA3 |
Laminin, alpha 3 (nicein (150 kD), kalinin (165 kD), BM600 (150 kD), epilegrin) |
| U65932_at |
ECM1 |
Extracellular matrix protein 1 |
| D87953_at |
NDRG1 |
N-Myc downstream regulated |
|
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Genes in bold were found upregulated in xenograft tumors over cultures for both cell lines with p < 0.05 in each. For A549, underlined genes were also found upregulated in lung tumors over A549 cultures with p < 0.05. For U118, underlined genes were also found upregulated in brain tumors over U118 cultures with p < 0.05. |
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Creighton et al. Genome Biology 2003 4:R46 doi:10.1186/gb-2003-4-7-r46 |
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