Figure 3.

FISH detection of Mater duplication. (a) Metaphase FISH showing three pairs of signals (yellow) detected on mouse chromosome 7 using BAC clone RP23-225F5 (detection frequency of 70%) mapping to duplicated Mater regions. (b) DAPI banding of the same partial mitotic figures for the identification of mouse chromosome 7. A control probe RP23-464L20 was mapped to a single location in the F2 region (data not shown).