Table 3

Examples of recent mouse gene duplications
Locus1*
 Gene
 Percent identity†
 Annotation
 Locus2*
 Gene
 Percent identity†
 Annotation
 Duplication % identity‡
1 F
 NM_009888
 99.6
 Cfh (Complement component factor h)
 1 F
 M29010
 99.0
 Complement factor H-related protein mRNA
 97.1
3 G1
 NM_009669
 100
 Amy2 (Amylase 2, pancreatic)
 3 G1
 M11896
 99.6
 Pancreatic amylase B-1
 97.6
5 E2
 NM_053184
 99.9
 Ugt2a1 (UDP glycosyltransferase 2 A1)
 5 E2
 BF144793
 99.6
 cDNA clone IMAGE:4021939
 95.7
5 E2
 NM_009467
 100
 Ugt2b5(UDP-glucuronosyl-transferase 2b5)
 5 E2
 NM_053215
 100
 RIKEN cDNA 0610033E06 gene
 93.3
5 E4
 NM_008620
 99.9
 Mpa2 (macrophage activation 2)
 5 E4
 BC007143
 99.5
 Similar to macrophage activation 2
 90.6
5 G1
 NM_029693
 100
 RIKEN cDNA 1700123K08
 7 B2
 NM_027702
 100
 RIKEN cDNA 4933421I07 gene
 91.1
6 C1
 NM_053238
 100
 V1rc8 (Vomeronasal 1 receptor, C8)
 6 C1
 NM_053239
 99.7
 V1rc9 (Vomeronasal 1 receptor, C9)
 95.1
6 D1
 NM_011467
 99.9
 Spr (sepiapterin reductase)
 6 D1
 BE862957
 99.5
 EST sequence
 95.8
6 F1
 AI505330
 100
 Similar to initiation factor eIF-4AI
 6 F1
 AI503670
 99.8
 Similar to initiation factor eIF-4AI
 98.9
6 F2
 NM_008646
 99.9
 Mug2 (Murinoglobulin 2)
 6 F2
 NM_008645
 99.9
 Mug1 (Murinoglobulin 1)
 94.6
6 F3
 NM_020257
 99.8
 Dcl1 (c-type lectin 1)
 6 F3
 NM_027562
 99.9
 4632413B12Rik (C-lectin related protein)
 90.8
6 F3
 NM_008463
 99.7
 Klra5 (Killer cell lectin-like receptor, A5)
 6 F3
 NM_008464
 99.5
 Klra6 (Killer cell lectin-like receptor, A6)
 90.0
6 F3
 NM_010649
 99.8
 Klra4 (Killer cell lectin-like receptor A4)
 6 F3
 NM_016659
 99.8
 Klra1 (Killer cell lectin-like receptor A1)
 91.4
6 F3
 NM_010737
 99.8
 Klrb1b (Killer cell lectin-like receptor 1b)
 6 F3
 NM_008527
 99.9
 Klrb1c (Killer cell lectin-like receptor 1c)
 90.8
7 A2
 NM_011860
 100
 Mater (Maternal effect gene)
 7 A1
 AK016782
 100
 Similar to Mater protein
 96.6
7 B1
 NM_032541
 100
 Hamp hepcidin antimicrobial peptide
 7 B1
 AK007975
 99.8
 Prohepcidin homolog
 92.8
7 B2
 NM_010115
 99
 Klk13 (Kallikrein 13)
 7 B2
 NM_008454
 99.9
 Klk16 (Kallikrein 16)
 92.2
8 D1
 L11333
 99.9
 Carboxylesterase
 8 D1
 NM_144511
 100
 Es31
 95.2
9 F4
 NM_130864
 99.6
 Acaa acetyl-Coenzyme A acyltransferase
 9 F4
 BC019882
 100
 Similar to acetyl-CoA acyltransferase
 96.6
10 B3
 NM_013532
 99.9
 Gp49a (Glycoprotein 49A)
 10 B3
 NM_008147
 100
 Gp49b (glycoprotein 49B)
 96.7
10 D2
 NM_017372
 100
 Lyzs (Lysozyme)
 10 D2
 NM_013590
 99.8
 Lzp-s (P lysozyme structural)
 95.3
11 A3.2
 NM_172792
 100
 hypothetical protein 4932414J04
 17 D
 AK03001
 100
 Tyrosine protein kinase/cysteine-rich region
 94.0
11 B1.3
 NM_011396
 99.9
 Slc22a5 (Solute carrier family 22)
 11 B1.3
 NM_019723
 100
 Slc22a9 (solute carrier family 22)
 91.2
11 D
 NM_021347
 100
 Gsdm (Gasdermin)
 11 D
 NM_029727
 99.9
 2200001G21Rik
 94.2
12 F1
 BC002065
 99.6
 Serine protease inhibitor 2-1
 12 F1
 BY761363
 99.9
 EST sequence
 92.2
12 F1
 NM_013772
 100
 Tcl1b3 (T-cell leukemia/lymphoma 1B, 3)
 12 F1
 NM_013776
 100
 Tcl1b5 (T-cell leukemia/lymphoma 1B, 5)
 95.3
13 A1
 NM_013778
 99.5
 Akr1c13 (Aldo-keto reductase 1, C13)
 13 A1
 NM_013777
 99.5
 Akrc12 (Aldo-keto reductase 1, C12)
 96.1
13 A3
 NM_008864
 99.2
 Csh1 (chorionic somatomammotrophin 1)
 13 A3.3
 AK082929
 100
 Similar to placental lactogen 1
 98.8
13 A4
 NM_011456
 100
 Spi14 (Serine Protease Inhibitor 14)
 13 A4
 NM_011455
 100
 Spi13 (serine protease inhibitor 13)
 95.2
13 D1
 NM_010872
 100
 Birc1b (Neuronal apoptosis inhibitory 2)
 13 D1
 NM_008670
 99.9
 Birc1a (Neuronal apoptosis inhibitory 1)
 90.0
14 C1
 NM_010373
 99.7
 Gzme (Granzyme E)
 14 C1
 NM_010372
 99.9
 Gzmd (Granzyme D)
 94.7
14 C2
 NM_172603
 100
 4933417L10Rik
 14 C3
 BE381578
 100
 EST sequence
 94.0
15 E2
 NM_007781
 100
 Csf2rb2 (Colony stimulating factor 2, β-2)
 15 E2
 NM_007780
 99.8
 Csf2rb1 (Colony stimulating factor 2, β-1)
 95.0
15 E2
 NM_010005
 100
 Cyp2d10 (Cytochrome P450, 2d10)
 15 E2
 NM_010006
 100
 Cyp2d9 (cytochrome P450, 2d9)
 92.1
16 B1
 NM_023125
 100
 Kng (Kininogen)
 16 B1
 BI330914
 99.1
 EST sequence
 90.0
16 B3
 M92418
 99.8
 MS2 (Cysteine proteinase inhibitor)
 16 B3
 BB654253
 100
 EST sequence
 95.2
17 B2
 NM_009780
 99.9
 C4 (Complement component 4)
 17 B2
 M21576
 99.5
 Slp (MHC sex-limited protein)
 96.3
X A2
 NM_008955
 100
 Psx1 (Placenta specific homeobox 1)
 X A2
 NM_023894
 100
 Homeobox protein GPBOX
 91.6

*Locations of duplicons by mouse chromosome banding; locus 1 and 2 represent a duplication pair. †Alignment percent identity between gene and genomic sequences showing correct matches. ‡ % similarity: average DNA percent identity between paralogous gene/transcript sequences in locus 1 and 2 (duplicated pair)

Cheung et al. Genome Biology 2003 4:R47   doi:10.1186/gb-2003-4-8-r47