Table 4 |
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|
Protein domain enrichment found in recently duplicated mouse genes* |
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| InterPro entry ID |
Protein domain description |
Number found in 608 duplicated genes |
Number found in all 16,515 annotated genes in genome |
Enrichment† |
|
|
||||
| IPR000276 |
Rhodopsin-like GPCR superfamily |
135 |
1229 |
3.0 |
| IPR000725 |
Olfactory receptor |
103 |
861 |
3.3 |
| IPR003006 |
Immunoglobulin/major histocompatibility complex |
46 |
372 |
3.4 |
| IPR004072 |
Vomeronasal receptor, type 1 |
31 |
108 |
7.8 |
| IPR001909 |
KRAB box |
23 |
103 |
6.1 |
| IPR001254 |
Serine protease, trypsin family |
21 |
117 |
4.9 |
| IPR002401 |
E-class P450, group I |
20 |
61 |
8.9 |
| IPR001128 |
Cytochrome P450 |
20 |
68 |
8.0 |
| IPR007086 |
Zn-finger, C2H2 subtype |
20 |
139 |
3.9 |
| IPR001314 |
Chymotrypsin serine protease, family S1 |
19 |
108 |
4.8 |
| IPR002403 |
E-class P450, group IV |
17 |
56 |
8.2 |
| IPR002397 |
B-class P450 |
13 |
29 |
11.9 |
| IPR001304 |
C-type lectin |
13 |
96 |
3.7 |
| IPR000215 |
Serpin |
12 |
48 |
6.8 |
| IPR002402 |
E-class P450, group II |
9 |
14 |
18.5 |
| IPR006046 |
Glycoside hydrolase family 13 |
7 |
8 |
23.0 |
| IPR006047 |
Alpha amylase, catalytic domain |
7 |
10 |
19.2 |
| IPR001400 |
Somatotropin hormone |
7 |
32 |
6.1 |
| IPR006048 |
Alpha amylase, C-terminal all-beta domain |
6 |
7 |
24.7 |
| IPR002018 |
Carboxylesterase, type B |
6 |
13 |
12.3 |
| IPR004073 |
Vomeronasal receptor, type 2 |
6 |
13 |
12.3 |
| IPR001039 |
Major histocompatibility complex protein, class I |
6 |
17 |
9.9 |
| IPR001828 |
Extracellular ligand-binding receptor |
6 |
29 |
5.5 |
| IPR002213 |
UDP-glucoronosyl/UDP-glucosyl transferase |
5 |
12 |
11.8 |
| IPR002448 |
Odour-binding protein |
4 |
9 |
13.2 |
| IPR000068 |
Extracellular calcium-sensing receptor |
4 |
10 |
11.0 |
|
|
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|
*Only Ensembl gene annotation (608 genes) was used in this analysis. †All results shown are statistically significant with p-values < 10-5 (chi2 test). |
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|
Cheung et al. Genome Biology 2003 4:R47 doi:10.1186/gb-2003-4-8-r47 |
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