Table 5

Genes that have undergone recent duplication in both the mouse and human genome*

Refseq^†

Gene description

NM_007534

B-cell leukemia/lymphoma 2 related protein A1b (Bcl2a1b)

NM_007558

Bone morphogenetic protein 8a (Bmp8a)

NM_007812

Cytochrome P450, 2a5 (Cyp2a5)

NM_008181

Glutathione S-transferase, alpha 1 (Ya) (Gsta1)

NM_010390

Histocompatibility 2, Q region locus 1 (H2Q1)

NM_009467

UDP-glucuronosyltransferase 2 family, member 5 (Ugt2b5)

NM_009669

Amylase 2, pancreatic (Amy2)

NM_009888

Complement component factor h (Cfh)

NM_010856

Myosin heavy chain, cardiac muscle, adult (Myhca)

NM_013778

Aldo-keto reductase family 1, member C13 (Akr1c13)

NM_022033

3-Oxoacid CoA transferase 2 (Oxct2) (Imbedded in the Bmp8a gene)

NM_026419

Elastase 3B, pancreatic (Ela3b)

NM_031176

Tenascin XB (Tnxb)

NM_130864

Acetyl-coenzyme A acyltransferase (peroxisomal 3-oxoacyl-Coenzyme athiolase) (Acaa)

NM_010997

Olfactory receptor 54 (Olfr54)

NM_031170

Keratin complex 2, basic, gene 8 (Krt2-8)

*Six hundred and seventy-five duplicated mouse gene sequences were aligned to the June 2002 human genome assembly by BLAST (with an initial expected value cutoff of <10^-10). The best aligned human genes were subsequently used for reciprocal BLAST alignments (against the mouse genome sequence) to establish a putative orthologous relationship between the mouse and human gene pairs. Using results from our human genome duplication analysis [9,37], we examined regions of the human genome where the human genes are involved in recent segmental duplication. ^†Italics represents genes that are entirely within a duplication in the mouse genome.

Cheung et al. Genome Biology 2003 4:R47   doi:10.1186/gb-2003-4-8-r47