Refinement of a chimpanzee pericentric inversion breakpoint to a segmental duplication cluster
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* Corresponding author: Evan E Eichler eee@cwru.edu
Genome Biology 2003, 4:R50 doi:10.1186/gb-2003-4-8-r50
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On the association between chromosomal rearrangements and genic evolution in humans and chimpanzees Tomàs Marques-Bonet, Jesús Sànchez-Ruiz, Lluís Armengol, Razi Khaja, Jaume Bertranpetit, Núria Lopez-Bigas, Mariano Rocchi, Elodie Gazave, Arcadi Navarro Genome Biology 2007, 8:R230 (30 October 2007) Analysis of the genes located in rearranged human and chimpanzee chromosomes identified lower divergence than for those in colinear chromosomes. |
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Research
Is mammalian chromosomal evolution driven by regions of genome fragility? Aurora Ruiz-Herrera, Jose Castresana, Terence J Robinson Genome Biology 2006, 7:R115 (8 December 2006) An analysis of the distribution of evolutionary breakpoints in eight species suggests that certain human chromosomal regions are repeatedly used during the evolutionary process, are associated with fragile sites, and show an enrichment of tandem repeats. |
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Research
Hotspots of mammalian chromosomal evolution Jeffrey A Bailey, Robert Baertsch, W Kent, David Haussler, Evan E Eichler Genome Biology 2004, 5:R23 (8 March 2004) This study reports an abundance of primate-specific segmental duplications at the breakpoints of syntenic blocks in the human genome. Segmental duplications are associated with syntenic rearrangements but do not necessarily cause them. |