Figure 2.

Pericentric inversion of HSA 15q11-q13 in chimpanzee two-color FISH. Probe RP11-88O16 (red), located in distal human 15q13.3, and probe pDJ-778A2 (green), which hybridizes to the HERC2-related PWS/AS breakpoint clusters in 15q11.2 and 15q13.1 clearly demonstrate the inversion of HSA 15q proximal material in chimpanzee (b). Humans (a) share the ancestral state with gorilla (c) and orangutan (d). The DAPI image for each chromosome is shown above the hybridization image and centromeres are indicated by the arrows.