Different evolutionary patterns between young duplicate genes in the human genome
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* Corresponding author: Wen-Hsiung Li whli@uchicago.edu
Genome Biology 2003, 4:R56 doi:10.1186/gb-2003-4-9-r56
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Chungoo Park, Kateryna D Makova Genome Biology 2009, 10:R10 (28 January 2009) Gene expression data for duplicated gene pairs in humans provides insights into the regulatory factors affecting the expression divergence of these genes and implications for their evolution. |
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Tomàs Marques-Bonet, Ze Cheng, Xinwei She, Evan E Eichler, Arcadi Navarro BMC Genomics 2008, 9:384 (12 August 2008) |
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On the association between chromosomal rearrangements and genic evolution in humans and chimpanzees Tomàs Marques-Bonet, Jesús Sànchez-Ruiz, Lluís Armengol, Razi Khaja, Jaume Bertranpetit, Núria Lopez-Bigas, Mariano Rocchi, Elodie Gazave, Arcadi Navarro Genome Biology 2007, 8:R230 (30 October 2007) Analysis of the genes located in rearranged human and chimpanzee chromosomes identified lower divergence than for those in colinear chromosomes. |
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Improving the specificity of high-throughput ortholog prediction Debra L Fulton, Yvonne Y Li, Matthew R Laird, Benjamin GS Horsman, Fiona M Roche, Fiona SL Brinkman BMC Bioinformatics 2006, 7:270 (28 May 2006) A new high-throughput method, Ortholuge, utilizes phylogenetic distance ratios to distinguish orthologous genes from those that are paralogous, and can be used on bacteria and eukaryotes on a genome-wide scale.
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Fast rate of evolution in alternatively spliced coding regions of mammalian genes Ekaterina O Ermakova, Ramil N Nurtdinov, Mikhail S Gelfand BMC Genomics 2006, 7:84 (18 April 2006) A comparison of orthologous human and mouse genes indicates that alternatively spliced exons tend to have a faster rate of evolution than constitutive exons, with the rate of both synonymous and nonsynonymous substitutions increased.
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Many genes in fish have species-specific asymmetric rates of molecular evolution Dirk Steinke, Walter Salzburger, Ingo Braasch, Axel Meyer BMC Genomics 2006, 7:20 (8 February 2006) |
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Rapid and asymmetric divergence of duplicate genes in the human gene coexpression network Wen-Yu Chung, Reka Albert, Istvan Albert, Anton Nekrutenko, Kateryna D Makova BMC Bioinformatics 2006, 7:46 (27 January 2006) When genes duplicate, they quickly diverge, losing shared coexpressed partners and acquiring different new partners according to a human coexpression network analysis that utilized tissue-specific microarray data.
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A combined approach exploring gene function based on Worm-Human Orthology Ivica Tamas, Emily Hodges, Patrick Dessi, Robert Johnsen, Ana Vaz Gomes BMC Genomics 2005, 6:65 (6 May 2005) |
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Duplicated genes evolve slower than singletons despite the initial rate increase I King Jordan, Yuri I Wolf, Eugene V Koonin BMC Evolutionary Biology 2004, 4:22 (6 July 2004) Following gene duplication there is a period of rapid evolution, which then slows down in cases where the original gene has an important biological function and the duplicate is retained.
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