DAVID: Database for Annotation, Visualization, and Integrated Discovery

Glynn Dennis Jr¹, Brad T Sherman¹, Douglas A Hosack¹, Jun Yang¹, Wei Gao¹, H Clifford Lane² and Richard A Lempicki¹

¹Science Applications International Corporation - Frederick, Clinical Services Program, Laboratory of Immunopathogenesis and Bioinformatics, National Cancer Institute at Frederick, MD 21702, USA

²Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA

author email corresponding author email

Genome Biology 2003, 4:R60doi:10.1186/gb-2003-4-9-r60


Published:	14 August 2003

A previous version of this manuscript was made available before peer review at http://genomebiology.com/2003/4/5/P3

Subject areas: Bioinformatics, Genome studies

Abstract

The distributed nature of biological knowledge poses a major challenge to the interpretation of genome-scale datasets, including those derived from microarray and proteomic studies. This report describes DAVID, a web-accessible program that integrates functional genomic annotations with intuitive graphical summaries. Lists of gene or protein identifiers are rapidly annotated and summarized according to shared categorical data for Gene Ontology, protein domain, and biochemical pathway membership. DAVID assists in the interpretation of genome-scale datasets by facilitating the transition from data collection to biological meaning.