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Highly AccessReview

Computational prediction of transcription-factor binding site locations

Martha L Bulyk email

Division of Genetics, Departments of Medicine, Pathology and Harvard/MIT Division of Health Sciences and Technology, Brigham and Women's Hospital and Harvard Medical School, New Research Building, 77 Avenue Louis Pasteur, Boston, MA 02115, USA

author email corresponding author email

Genome Biology 2003, 5:201doi:10.1186/gb-2003-5-1-201

Published: 23 December 2003

Subject areas: Molecular biology, Bioinformatics, Genome studies, Evolution

Abstract

Identifying genomic locations of transcription-factor binding sites, particularly in higher eukaryotic genomes, has been an enormous challenge. Various experimental and computational approaches have been used to detect these sites; methods involving computational comparisons of related genomes have been particularly successful.


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