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Highly Accessed Review

Computational prediction of transcription-factor binding site locations

Martha L Bulyk

Author Affiliations

Division of Genetics, Departments of Medicine, Pathology and Harvard/MIT Division of Health Sciences and Technology, Brigham and Women's Hospital and Harvard Medical School, New Research Building, 77 Avenue Louis Pasteur, Boston, MA 02115, USA

Genome Biology 2003, 5:201  doi:10.1186/gb-2003-5-1-201

Published: 23 December 2003

Abstract

Identifying genomic locations of transcription-factor binding sites, particularly in higher eukaryotic genomes, has been an enormous challenge. Various experimental and computational approaches have been used to detect these sites; methods involving computational comparisons of related genomes have been particularly successful.