Table 3

Functional analysis of actual versus random miRNAs

GO molecular function class


Transcription regulator

Apoptosis regulator

Cell adhesion molecule

Binding

Enzyme

Transporter

Signal transducer

Translation regulator

Motor

Enzyme regulator

Structural molecule

Chaperone


Actual miRNAs

113

6

10

146

128

35

66

4

6

9

6

1

Random miRNAs (average)

43

1

2

98

88

22

41

2

4

9

7

1

Standard deviation

± 7.5

± 0.9

± 1.5

± 13.3

± 13.7

± 4.9

± 9.7

± 1.3

± 2.2

± 3.9

± 2.6

± 1.2

Z-score

9.3

5.9

5.0

3.6

2.9

2.7

2.6

1.4

1.0

0.01

-0.3

-0.3


Integers are number of detected conserved cases in each class. The standard deviation is for 50 experiments. The Z-scores for seven functional classes indicate over-represention for actual miRNA target genes. The thresholds used are S: 100; ΔG: -19 kcal/mol; ID: 70%.

Enright et al. Genome Biology 2003 5:R1   doi:10.1186/gb-2003-5-1-r1

Open Data