Table 1

Androgen-sensitive and androgen-insensitive cellular processes

Group

Cellular process

ICAT-labeled protein ratios ≥1.6

ICAT-labeled proteins in cellular process

Observed compared with expected

p-value

38

RNA splicing

12

14

Over

5.92E-05

18

Energy generation

38

74

Over

3.01E-04

25

Nucleotide metabolism

30

56

Over

5.20E-04

43

Vesicular transport

12

68

Under

1.87E-03

19

Lipid, fat and sterol metabolism

31

63

Over

2.30E-03

37

RNA processing/modification

25

48

Over

2.32E-03

35

Protein synthesis

17

84

Under

3.11E-03

For each cellular process category, the observed number of proteins showing an ICAT ratio ≥1.6 was compared to the number expected at random. Using the hypergeometric distribution, a p-value was calculated for each cellular process category from four numbers: the total number of ICAT-reagent labeled proteins (1,064), the total number of proteins with ICAT ratios ≥1.6 (350), the number of ICAT-reagent labeled proteins in the cellular process category, and the number of ICAT-reagent labeled proteins in the cellular process category with a ratio ≥1.6. Cellular process categories showing low p-values are shown. Each of these has either an over-representation of changed proteins or an under-representation.

Wright et al. Genome Biology 2003 5:R4