Genomic and proteomic adaptations to growth at high temperature

doi:10.1186/gb-2004-5-10-117

Genome Biology

Volume 5
Issue 10

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Opinion

Genomic and proteomic adaptations to growth at high temperature

Donal A Hickey¹ and Gregory AC Singer¹^,2

¹Department of Biology, Concordia University, 7141 Sherbrooke Street, Montreal, Quebec, H4B 1R6, Canada

²Human Cancer Genetics Program, Comprehensive Cancer Center, Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA

author email corresponding author email

Genome Biology 2004, 5:117doi:10.1186/gb-2004-5-10-117


Published:	30 September 2004

Subject areas: Evolution, Biochemistry and structural biology, Microbiology and parasitology, Molecular biology, Physiology

Abstract

Most positively selected mutations cause changes in metabolism, resulting in a better-adapted phenotype. But as well as acting on the information content of genes, natural selection may also act directly on nucleic acid and protein molecules. We review the evidence for direct temperature-dependent natural selection acting on genomes, transcriptomes and proteomes.