Hotspots of homologous recombination in the human genome: not all homologous sequences are equal

doi:10.1186/gb-2004-5-10-242

Genome Biology

Volume 5
Issue 10

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Hotspots of homologous recombination in the human genome: not all homologous sequences are equal

James R Lupski¹^,2

¹Departments of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA

²Current address (sabbatical until July 2005): Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 ISA, UK

author email corresponding author email

Genome Biology 2004, 5:242doi:10.1186/gb-2004-5-10-242


Published:	28 September 2004

Subject areas: Genetics, Genome studies, Evolution

Abstract

Homologous recombination between alleles or non-allelic paralogous sequences does not occur uniformly but is concentrated in 'hotspots' with high recombination rates. Recent studies of these hotspots show that they do not share common sequence motifs, but they do have other features in common.