Hotspots of homologous recombination in the human genome: not all homologous sequences are equal
Departments of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
Current address (sabbatical until July 2005): Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 ISA, UK
Genome Biology 2004, 5:242 doi:10.1186/gb-2004-5-10-242Published: 28 September 2004
Homologous recombination between alleles or non-allelic paralogous sequences does not occur uniformly but is concentrated in 'hotspots' with high recombination rates. Recent studies of these hotspots show that they do not share common sequence motifs, but they do have other features in common.