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Global nucleosome distribution and the regulation of transcription in yeast

Sevinc Ercan1,2, Michael J Carrozza1 and Jerry L Workman1 email

Stowers Institute for Medical Research, 1,000 East 50th Street, Kansas City, MO 64110, USA

Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA

author email corresponding author email

Genome Biology 2004, 5:243doi:10.1186/gb-2004-5-10-243

Published: 30 September 2004

Subject areas: Molecular biology, Genome studies, Model organisms

Abstract

Recent studies show that active regulatory regions of the yeast genome have a lower density of nucleosomes than other regions, and that there is an inverse correlation between nucleosome density and the transcription rate of a gene. This may be the result of transcription factors displacing nucleosomes.


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