Global nucleosome distribution and the regulation of transcription in yeast
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* Corresponding author: Jerry L Workman JLW@Stowers-Institute.org
1 Stowers Institute for Medical Research, 1,000 East 50th Street, Kansas City, MO 64110, USA
2 Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA
Genome Biology 2004, 5:243 doi:10.1186/gb-2004-5-10-243
Published: 30 September 2004Abstract
Recent studies show that active regulatory regions of the yeast genome have a lower density of nucleosomes than other regions, and that there is an inverse correlation between nucleosome density and the transcription rate of a gene. This may be the result of transcription factors displacing nucleosomes.