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Global nucleosome distribution and the regulation of transcription in yeast

Sevinc Ercan12, Michael J Carrozza1 and Jerry L Workman1*

Author Affiliations

1 Stowers Institute for Medical Research, 1,000 East 50th Street, Kansas City, MO 64110, USA

2 Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA

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Genome Biology 2004, 5:243  doi:10.1186/gb-2004-5-10-243

Published: 30 September 2004

Abstract

Recent studies show that active regulatory regions of the yeast genome have a lower density of nucleosomes than other regions, and that there is an inverse correlation between nucleosome density and the transcription rate of a gene. This may be the result of transcription factors displacing nucleosomes.