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Gene-dosage effects in Down syndrome and trisomic mouse models

Katheleen Gardiner

Genome Biology 2004, 5:244 doi:10.1186/gb-2004-5-10-244

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BioMed Central: 2 citations

Research article   Open Access

Altered expression of mitochondrial and extracellular matrix genes in the heart of human fetuses with chromosome 21 trisomy

Anna Conti, Floriana Fabbrini, Paola D'Agostino, Rosa Negri, Dario Greco, Rita Genesio, Maria D'Armiento, Carlo Olla, Dario Paladini, Mariastella Zannini, Lucio Nitsch BMC Genomics 2007, 8:268 (7 August 2007)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Cell type-specific over-expression of chromosome 21 genes in fibroblasts and fetal hearts with trisomy 21

Chi-Ming Li, Meirong Guo, Martha Salas, Nicole Schupf, Wayne Silverman, Warren B Zigman, Sameera Husain, Dorothy Warburton, Harshwardhan Thaker, Benjamin Tycko BMC Medical Genetics 2006, 7:24 (15 March 2006)

Abstract | Full text | PDF | PubMed | Editor’s summary

Differential over-expression of chromosome 21 genes in trisomy 21 fibroblasts and fetal hearts may help explain the occurrence of cardiac defects and autoimmune diseases in patients with Down syndrome.

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