Table 1

Overview of studies of gene-dosage effects in trisomies

Mao et al. [6]
 Amano et al. [7]
 Kahlem et al. [8]
 Lyle et al. [9]
Species and strain
 Humans with Down syndrome
 Ts1Cje mice
 Ts65Dn mice
 Ts65Dn mice
Number of individuals
 4 plus 4 controls
 6 plus 6 controls
 4 plus 4 controls
 4 plus 4 controls
Ages
 17-20 weeks gestation
 Postnatal day 0
 3-4 months
 Postnatal day 30 and 11 months
Tissues
 Cerebrum and cortex-derived astrocyte cell lines
 Whole brains
 Cortex, midbrain, cerebellum, heart, testis, liver, kidney, lung, and muscle
 Brain, liver, kidney, heart, muscle, and lung
Technique used
 Affymetrix microarrays
 Affymetrix microarrays
 Custom cDNA array
 RT-PCR
Number of genes on trisomic segment
 Over 300
 71
 94 (77 tested in 9 tissues)
 94 (78 tested in 10 tissues)
Trisomic genes increased in expression
 25 (variation among individuals)
 37 (variation among individuals)
 All genes (of 66 with detectable expression) except in muscle and 10 gene-tissue combinations
 607 gene-tissue combinations (of 666 with detectable expression)
Non-trisomic genes with altered expression
 Approximately 185
 258
 Not determined
 Not determined

Gardiner Genome Biology 2004 5:244   doi:10.1186/gb-2004-5-10-244