Genome Biology

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Bioconductor: open software development for computational biology and bioinformatics

Robert C Gentleman*, Vincent J Carey, Douglas M Bates, Ben Bolstad, Marcel Dettling, Sandrine Dudoit, Byron Ellis, Laurent Gautier, Yongchao Ge, Jeff Gentry, Kurt Hornik, Torsten Hothorn, Wolfgang Huber, Stefano Iacus, Rafael Irizarry, Friedrich Leisch, Cheng Li, Martin Maechler, Anthony J Rossini, Gunther Sawitzki, Colin Smith, Gordon Smyth, Luke Tierney, Jean YH Yang and Jianhua Zhang

Genome Biology 2004, 5:R80 doi:10.1186/gb-2004-5-10-r80

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Genome-wide landscape of liver X receptor chromatin binding and gene regulation in human macrophages

Petri Pehkonen, Lynn Welter-Stahl, Janine Diwo, Jussi Ryynanen, Anke Wienecke-Baldacchino, Sami Heikkinen, Eckardt Treuter, Knut R Steffensen, Carsten Carlberg BMC Genomics 2012, 13:50 (31 January 2012)

Research article   Open Access

The role of the Arabidopsis FUSCA3 transcription factor during inhibition of seed germination at high temperature

Rex S Chiu, Hardeep Nahal, Nicholas J Provart, Sonia Gazzarrini BMC Plant Biology 2012, 12:15 (27 January 2012)

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An evaluation of two-channel ChIP-on-chip and DNA methylation microarray normalization strategies.

Michiel E Adriaens, Magali Jaillard, Lars MT Eijssen, Claus-Dieter Mayer, Chris TA Evelo BMC Genomics 2012, 13:42 (25 January 2012)

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Interleukin-8 is the single most up-regulated gene in whole genome profiling of H. pylori exposed gastric epithelial cells

Lars L Eftang, Ying Esbensen, Tone M Tannaes, Ida RK Bukholm, Geir Bukholm BMC Microbiology 2012, 12:9 (17 January 2012)

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The genetic control of growth rate: a systems biology study in yeast.

Pinar Pir, Alex Gutteridge, Jian Wu, Bharat Rash, Douglas B Kell, Nianshu Zhang, Stephen G Oliver BMC Systems Biology 2012, 6:4 (13 January 2012)

Research   Open Access

Systems-wide RNAi analysis of CASP8AP2/FLASH shows transcriptional deregulation of the replication-dependent histone genes and extensive effects on the transcriptome of colorectal cancer cells

Amanda B Hummon, Jason J Pitt, Jordi Camps, Georg Emons, Susan B Skube, Konrad Huppi, Tamara L Jones, Tim Beissbarth, Frank Kramer, Marian Grade, Michael J Difilippantonio, Thomas Ried, Natasha J Caplen Molecular Cancer 2012, 11:1 (4 January 2012)

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Partition decoupling for multi-gene analysis of gene expression profiling data

Rosemary Braun, Gregory Leibon, Scott Pauls, Daniel Rockmore BMC Bioinformatics 2011, 12:497 (30 December 2011)

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Correlation of gene expression and protein production rate - a system wide study

Mikko Arvas, Tiina Pakula, Bart Smit, Jari Rautio, Heini Koivistoinen, Paula Jouhten, Erno Lindfors, Marilyn Wiebe, Merja Penttilä, Markku Saloheimo BMC Genomics 2011, 12:616 (20 December 2011)

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Genome-wide transcriptional profiling of peripheral blood leukocytes from cattle infected with Mycobacterium bovis reveals suppression of host immune genes

Kate E Killick, John A Browne, Stephen DE Park, David A Magee, Irene Martin, Kieran G Meade, Stephen V Gordon, Eamonn Gormley, Cliona O'Farrelly, Karsten Hokamp, David E MacHugh BMC Genomics 2011, 12:611 (19 December 2011)

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Expression QTL mapping in regulatory and helper T cells from the BXD family of strains reveals novel cell-specific genes, gene-gene interactions and candidate genes for auto-immune disease

Rudi Alberts, Hairong Chen, Claudia Pommerenke, August B Smit, Sabine Spijker, Robert W Williams, Robert Geffers, Dunja Bruder, Klaus Schughart BMC Genomics 2011, 12:610 (19 December 2011)

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Genetic architecture of gene expression in ovine skeletal muscle

Lisette JA Kogelman, Keren Byrne, Tony Vuocolo, Nathan S Watson-Haigh, Haja N Kadarmideen, James W Kijas, Hutton V Oddy, Graham E Gardner, Cedric Gondro, Ross L Tellam BMC Genomics 2011, 12:607 (15 December 2011)

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Jetset: selecting the optimal microarray probe set to represent a gene

Qiyuan Li, Nicolai J Birkbak, Balazs Gyorffy, Zoltan Szallasi, Aron C Eklund BMC Bioinformatics 2011, 12:474 (15 December 2011)

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Genome-wide transcriptome analysis of gametophyte development in Physcomitrella patens

Lihong Xiao, Hui Wang, Ping Wan, Tingyun Kuang, Yikun He BMC Plant Biology 2011, 11:177 (15 December 2011)

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Variants on the promoter region of PTEN affect breast cancer progression and patient survival

Tuomas Heikkinen, Dario Greco, Liisa M Pelttari, Johanna Tommiska, Pia Vahteristo, Päivi Heikkilä, Carl Blomqvist, Kristiina Aittomäki, Heli Nevanlinna Breast Cancer Research 2011, 13:R130 (15 December 2011)

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More than just a metabolic regulator - elucidation and validation of new targets of PdhR in Escherichia coli

Anna-Katharina Göhler, Öznur Kökpinar, Wolfgang Schmidt-Heck, Robert Geffers, Reinhard Guthke, Ursula Rinas, Stefan Schuster, Knut Jahreis, Christoph Kaleta BMC Systems Biology 2011, 5:197 (14 December 2011)

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Identification of dysfunctional modules and disease genes in congenital heart disease by a network-based approach

Danning He, Zhi-Ping Liu, Luonan Chen BMC Genomics 2011, 12:592 (2 December 2011)

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RNA-seq in grain unveils fate of neo- and paleopolyploidization events in bread wheat (Triticum aestivum L.)

Caroline Pont, Florent Murat, Carole Confolent, Sandrine Balzergue, Jérôme Salse Genome Biology 2011, 12:R119 (2 December 2011)

Transcriptomics reveals the evolutionary trajectory of polyploidization, with insights into gene networks and genome organization

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Evaluation of the NOD/SCID xenograft model for glucocorticoid-regulated gene expression in childhood B-cell precursor acute lymphoblastic leukemia

Vivek A Bhadri, Mark J Cowley, Warren Kaplan, Toby N Trahair, Richard B Lock BMC Genomics 2011, 12:565 (17 November 2011)

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Rigorous and thorough bioinformatic analyses of olfactory receptor promoters confirm enrichment of O/E and homeodomain binding sites but reveal no new common motifs

Janet M Young, Ralf M Luche, Barbara J Trask BMC Genomics 2011, 12:561 (15 November 2011)

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Genome-wide analysis of gene expression during Xenopus tropicalis tadpole tail regeneration

Nick R Love, Yaoyao Chen, Boyan Bonev, Michael J Gilchrist, Lynne Fairclough, Robert Lea, Timothy J Mohun, Roberto Paredes, Leo AH Zeef, Enrique Amaya BMC Developmental Biology 2011, 11:70 (15 November 2011)

Methodology article   Open Access

Consistent Differential Expression Pattern (CDEP) on microarray to identify genes related to metastatic behavior

Lam C Tsoi, Tingting Qin, Elizabeth H Slate, W Jim Zheng BMC Bioinformatics 2011, 12:438 (11 November 2011)

Research article   Open Access

Conjugating effects of symbionts and environmental factors on gene expression in deep-sea hydrothermal vent mussels

Isabelle Boutet, Raymond Ripp, Odile Lecompte, Carole Dossat, Erwan Corre, Arnaud Tanguy, François H Lallier BMC Genomics 2011, 12:530 (28 October 2011)

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Gene network analyses point to the importance of human tissue kallikreins in melanoma progression

Waleska K Martins, Gustavo H Esteves, Otávio M Almeida, Gisele G Rezze, Gilles Landman, Sarah M Marques, Alex F Carvalho, Luiz F L Reis, João P Duprat, Beatriz S Stolf BMC Medical Genomics 2011, 4:76 (27 October 2011)

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Impact of the spotted microarray preprocessing method on fold-change compression and variance stability

Jérôme Ambroise, Bertrand Bearzatto, Annie Robert, Bernadette Govaerts, Benoît Macq, Jean-Luc Gala BMC Bioinformatics 2011, 12:413 (25 October 2011)

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High-throughput RNA interference screening using pooled shRNA libraries and next generation sequencing

David Sims, Ana M Mendes-Pereira, Jessica Frankum, Darren Burgess, Maria-Antonietta Cerone, Cristina Lombardelli, Costas Mitsopoulos, Jarle Hakas, Nirupa Murugaesu, Clare M Isacke, Kerry Fenwick, Ioannis Assiotis, Iwanka Kozarewa, Marketa Zvelebil, Alan Ashworth, Christopher J Lord Genome Biology 2011, 12:R104 (21 October 2011)

The incorporation of next generation sequencing into RNAi screening makes for a rapid, user-friendly and high-throughput method

Methodology   Open Access

Dynamic gene network reconstruction from gene expression data in mice after influenza A (H1N1) infection

Konstantina Dimitrakopoulou, Charalampos Tsimpouris, George Papadopoulos, Claudia Pommerenke, Esther Wilk, Kyriakos N Sgarbas, Klaus Schughart, Anastasios Bezerianos Journal of Clinical Bioinformatics 2011, 1:27 (21 October 2011)

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Analytical variables influencing the performance of a miRNA based laboratory assay for prediction of relapse in stage I non-small cell lung cancer (NSCLC)

Jesper Dahlgaard, Wiktor Mazin, Thomas Jensen, Mette Pøhl, Wiam Bshara, Anker Hansen, Eric Kanisto, Stephen Hamilton-Dutoit, Olfred Hansen, Henrik Hager, Henrik J Ditzel, Sai Yendamuri, Steen Knudsen BMC Research Notes 2011, 4:424 (19 October 2011)

Methodology article   Open Access

A computable cellular stress network model for non-diseased pulmonary and cardiovascular tissue

Walter K Schlage, Jurjen W Westra, Stephan Gebel, Natalie L Catlett, Carole Mathis, Brian P Frushour, Arnd Hengstermann, Aaron Van Hooser, Carine Poussin, Ben Wong, Michael Lietz, Jennifer Park, David Drubin, Emilija Veljkovic, Manuel C Peitsch, Julia Hoeng, Renee Deehan BMC Systems Biology 2011, 5:168 (19 October 2011)

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SpeCond: a method to detect condition-specific gene expression

Florence MG Cavalli, Richard Bourgon, Wolfgang Huber, Juan M Vaquerizas, Nicholas M Luscombe Genome Biology 2011, 12:R101 (18 October 2011)

A method to detect condition-specific gene expression from microarray data

Research article   Open Access

Transcriptomics of shading-induced and NAA-induced abscission in apple (Malus domestica) reveals a shared pathway involving reduced photosynthesis, alterations in carbohydrate transport and signaling and hormone crosstalk

Hong Zhu, Chris D Dardick, Eric P Beers, Ann M Callanhan, Rui Xia, Rongcai Yuan BMC Plant Biology 2011, 11:138 (17 October 2011)

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Chipster: user-friendly analysis software for microarray and other high-throughput data

M Aleksi Kallio, Jarno T Tuimala, Taavi Hupponen, Petri Klemelä, Massimiliano Gentile, Ilari Scheinin, Mikko Koski, Janne Käki, Eija I Korpelainen BMC Genomics 2011, 12:507 (14 October 2011)

Research article   Open Access

Deciphering c-MYC-regulated genes in two distinct tissues

Samuel C Robson, Lesley Ward, Helen Brown, Heather Turner, Ewan Hunter, Stella Pelengaris, Michael Khan BMC Genomics 2011, 12:476 (30 September 2011)

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Mulcom: a multiple comparison statistical test for microarray data in Bioconductor

Claudio Isella, Tommaso Renzulli, Davide Corà, Enzo Medico BMC Bioinformatics 2011, 12:382 (28 September 2011)

Research article   Open Access

mRNA expression profiles of primary high-grade central osteosarcoma are preserved in cell lines and xenografts

Marieke L Kuijjer, Heidi M Namløs, Esther I Hauben, Isidro Machado, Stine H Kresse, Massimo Serra, Antonio Llombart-Bosch, Pancras CW Hogendoorn, Leonardo A Meza-Zepeda, Ola Myklebost, Anne-Marie Cleton-Jansen BMC Medical Genomics 2011, 4:66 (20 September 2011)

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Thawing Frozen Robust Multi-array Analysis (fRMA)

Matthew N McCall, Rafael A Irizarry BMC Bioinformatics 2011, 12:369 (16 September 2011)

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Genome-wide expression assay comparison across frozen and fixed postmortem brain tissue samples

Maggie L Chow, Hai-Ri Li, Mary E Winn, Craig April, Cynthia C Barnes, Anthony Wynshaw-Boris, Jian-Bing Fan, Xiang-Dong Fu, Eric Courchesne, Nicholas J Schork BMC Genomics 2011, 12:449 (10 September 2011)

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Tissue-specific gene expression templates for accurate molecular characterization of the normal physiological states of multiple human tissues with implication in development and cancer studies

Pei-Ing Hwang, Huan-Bin Wu, Chin-Di Wang, Bai-Ling Lin, Cheng-Tao Chen, Shinsheng Yuan, Guani Wu, Ker-Chau Li BMC Genomics 2011, 12:439 (1 September 2011)

Gene Expression Templates (GET) can be used to identify the normal physiological state of various human tissues, with variation from this template allowing the identification of cancerous tissues and cell lines.

Research article   Open Access

A eukaryotic-type signalling system of Pseudomonas aeruginosa contributes to oxidative stress resistance, intracellular survival and virulence

Jana Goldová, Aleš Ulrych, Kamil Hercík, Pavel Branny BMC Genomics 2011, 12:437 (31 August 2011)

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Cistrome: an integrative platform for transcriptional regulation studies

Tao Liu, Jorge A Ortiz, Len Taing, Clifford A Meyer, Bernett Lee, Yong Zhang, Hyunjin Shin, Swee S Wong, Jian Ma, Ying Lei, Utz J Pape, Michael Poidinger, Yiwen Chen, Kevin Yeung, Myles Brown, Yaron Turpaz, X Shirley Liu Genome Biology 2011, 12:R83 (22 August 2011)

A Galaxy-based web application for integrative analysis of ChIP data

Methodology article   Open Access

Extracting quantitative genetic interaction phenotypes from matrix combinatorial RNAi

Elin Axelsson, Thomas Sandmann, Thomas Horn, Michael Boutros, Wolfgang Huber , Bernd Fischer BMC Bioinformatics 2011, 12:342 (17 August 2011)

Research article   Open Access

Gene expression profiling of human whole blood samples with the Illumina WG-DASL assay

Mary E Winn, Marian Shaw, Craig April, Brandy Klotzle, Jian-Bing Fan, Sarah S Murray, Nicholas J Schork BMC Genomics 2011, 12:412 (15 August 2011)

Methodology article   Open Access

NETGEM: Network Embedded Temporal GEnerative Model for gene expression data

Vinay Jethava, Chiranjib Bhattacharyya, Devdatt Dubhashi, Goutham N Vemuri BMC Bioinformatics 2011, 12:327 (8 August 2011)

Research article   Open Access

Combined analysis of transcriptome and metabolite data reveals extensive differences between black and brown nearly-isogenic soybean (Glycine max) seed coats enabling the identification of pigment isogenes

Nik Kovinich, Ammar Saleem, John T Arnason, Brian Miki BMC Genomics 2011, 12:381 (29 July 2011)

Research   Open Access

Estrogens regulate neuroinflammatory genes via estrogen receptors α and β in the frontal cortex of middle-aged female rats

Miklós Sárvári, Erik Hrabovszky, Imre Kalló, Norbert Solymosi, Kinga Tóth, István Likó, János Széles, Sándor Mahó, Béla Molnár, Zsolt Liposits Journal of Neuroinflammation 2011, 8:82 (20 July 2011)

Research article   Open Access

Anti-inflammatory effects of tetradecylthioacetic acid (TTA) in macrophage-like cells from Atlantic salmon (Salmo salar L.)

Fabian Grammes, Harald Takle BMC Immunology 2011, 12:41 (20 July 2011)

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Construction of a computable cell proliferation network focused on non-diseased lung cells

Jurjen W Westra, Walter K Schlage, Brian P Frushour, Stephan Gebel, Natalie L Catlett, Wanjiang Han, Sean F Eddy, Arnd Hengstermann, Andrea L Matthews, Carole Mathis, Rosemarie B Lichtner, Carine Poussin, Marja Talikka, Emilija Veljkovic, Aaron A Van Hooser, Benjamin Wong, Michael J Maria, Manuel C Peitsch, Renee Deehan, Julia Hoeng BMC Systems Biology 2011, 5:105 (2 July 2011)

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The functional cancer map: A systems-level synopsis of genetic deregulation in cancer

Markus Krupp, Thorsten Maass, Jens U Marquardt, Frank Staib, Tobias Bauer, Rainer König, Stefan Biesterfeld, Peter R Galle, Achim Tresch, Andreas Teufel BMC Medical Genomics 2011, 4:53 (30 June 2011)

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MicroRNA genes preferentially expressed in dendritic cells contain sites for conserved transcription factor binding motifs in their promoters

Bastiaan JH Jansen, Iziah E Sama, Dagmar Eleveld-Trancikova, Maaike A van Hout-Kuijer, Joop H Jansen, Martijn A Huynen, Gosse J Adema BMC Genomics 2011, 12:330 (27 June 2011)

Methodology article   Open Access

Cell subset prediction for blood genomic studies

Christopher R Bolen, Mohamed Uduman, Steven H Kleinstein BMC Bioinformatics 2011, 12:258 (24 June 2011)

Research article   Open Access

Deregulation upon DNA damage revealed by joint analysis of context-specific perturbation data

Ewa Szczurek, Florian Markowetz, Irit Gat-Viks, Przemysław Biecek, Jerzy Tiuryn, Martin Vingron BMC Bioinformatics 2011, 12:249 (21 June 2011)

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Network target for screening synergistic drug combinations with application to traditional Chinese medicine

Shao Li, Bo Zhang, Ningbo Zhang BMC Systems Biology 2011, 5(Suppl 1):S10 (20 June 2011)

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Comparative genomics of Escherichia coli isolated from patients with inflammatory bowel disease

Rebecca Vejborg, Viktoria Hancock, Andreas M Petersen, Karen A Krogfelt, Per Klemm BMC Genomics 2011, 12:316 (15 June 2011)

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Chromosome-wide mapping of DNA methylation patterns in normal and malignant prostate cells reveals pervasive methylation of gene-associated and conserved intergenic sequences

Srinivasan Yegnasubramanian, Zhijin Wu, Michael C Haffner, David Esopi, Martin J Aryee, Raghav Badrinath, Tony L He, James D Morgan, Benilton Carvalho, Qizhi Zheng, Angelo M De Marzo, Rafael A Irizarry, William G Nelson BMC Genomics 2011, 12:313 (13 June 2011)

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Evaluating methods for ranking differentially expressed genes applied to microArray quality control data

Koji Kadota, Kentaro Shimizu BMC Bioinformatics 2011, 12:227 (6 June 2011)

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Gene coexpression clusters and putative regulatory elements underlying seed storage reserve accumulation in Arabidopsis

Fred Y Peng, Randall J Weselake BMC Genomics 2011, 12:286 (2 June 2011)

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OntoCAT -- simple ontology search and integration in Java, R and REST/JavaScript

Tomasz Adamusiak, Tony Burdett, Natalja Kurbatova, K Joeri van der Velde, Niran Abeygunawardena, Despoina Antonakaki, Misha Kapushesky, Helen Parkinson, Morris A Swertz BMC Bioinformatics 2011, 12:218 (29 May 2011)

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Multiple testing for gene sets from microarray experiments

Insuk Sohn, Kouros Owzar, Johan Lim, Stephen L George, Stephanie Mackey Cushman, Sin-Ho Jung BMC Bioinformatics 2011, 12:209 (26 May 2011)

Proceedings   Open Access

Managing and querying gene expression data using Curray

Hasan Jamil, Aminul Islam BMC Proceedings 2011, 5(Suppl 2):S10 (28 April 2011)

Data Note   Open Access Highly Accessed

Flow cytometry data standards

Josef Spidlen, Parisa Shooshtari, Tobias R Kollmann, Ryan R Brinkman BMC Research Notes 2011, 4:50 (7 March 2011)

This article is part of a collection on Data standardization...

Novel open file formats can be used to describe flow cytometry data analysis in a standardized and computationally exchangeable format allowing for enhanced scientific collaboration and highlights the need for a public data repository.

Proceedings   Open Access

An intuitive Python interface for Bioconductor libraries demonstrates the utility of language translators

Laurent Gautier BMC Bioinformatics 2010, 11(Suppl 12):S11 (21 December 2010)

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An overview of the Hadoop/MapReduce/HBase framework and its current applications in bioinformatics

Ronald C Taylor BMC Bioinformatics 2010, 11(Suppl 12):S1 (21 December 2010)

Methodology article   Open Access

Optimizing transformations for automated, high throughput analysis of flow cytometry data

Greg Finak, Juan-Manuel Perez, Andrew Weng, Raphael Gottardo BMC Bioinformatics 2010, 11:546 (4 November 2010)

Technical Note   Open Access

EMA - A R package for Easy Microarray data analysis

Nicolas Servant, Eleonore Gravier, Pierre Gestraud, Cecile Laurent, Caroline Paccard, Anne Biton, Isabel Brito, Jonas Mandel, Bernard Asselain, Emmanuel Barillot, Philippe Hupé BMC Research Notes 2010, 3:277 (3 November 2010)

This article is part of a collection on Microarray normalization...

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Elimination of head and neck cancer initiating cells through targeting glucose regulated protein78 signaling

Meng-Ju Wu, Chia-Ing Jan, Yeou-Guang Tsay, Yau-Hua Yu, Chih-Yang Huang, Shu-Chun Lin, Chung-Ji Liu, Yu-Syuan Chen, Jeng-Fan Lo, Cheng-Chia Yu Molecular Cancer 2010, 9:283 (27 October 2010)

Proceedings   Open Access

Shrunken methodology to genome-wide SNPs selection and construction of SNPs networks

Yang Liu, Michael Ng BMC Systems Biology 2010, 4(Suppl 2):S5 (13 September 2010)

Research highlight   Free Highly Accessed

The missing graphical user interface for genomics

Michael C Schatz Genome Biology 2010, 11:128 (25 August 2010)

The Galaxy package for genomic analysis empowers regular users through a much-needed and user-friendly graphical web interface.

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Galaxy: a comprehensive approach for supporting accessible, reproducible, and transparent computational research in the life sciences

Jeremy Goecks, Anton Nekrutenko, James Taylor, Genome Biology 2010, 11:R86 (25 August 2010)

This article is part of a collection on Cloud computing tools and...

The Galaxy computing platform allows researchers to share data and data analysis workflows, facilitating easily reproducible analyses.

Review   Open Access

A maternal low protein diet has pronounced effects on mitochondrial gene expression in offspring liver and skeletal muscle; protective effect of taurine

Ole Mortensen, Hanne Olsen, Lis Frandsen, Peter Nielsen, Finn Nielsen, Niels Grunnet, Bjørn Quistorff Journal of Biomedical Science 2010, 17(Suppl 1):S38 (24 August 2010)

Introduction   Open Access

Proceedings of the ninth annual UT-ORNL-KBRIN Bioinformatics Summit 2010

Eric C Rouchka, Robert M Flight, Claire Rinehart BMC Bioinformatics 2010, 11(Suppl 4):I1 (23 July 2010)

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Pathway analysis of the transcriptome and metabolome of salt sensitive and tolerant poplar species reveals evolutionary adaption of stress tolerance mechanisms

Dennis Janz, Katja Behnke, Jörg-Peter Schnitzler, Basem Kanawati, Philippe Schmitt-Kopplin, Andrea Polle BMC Plant Biology 2010, 10:150 (17 July 2010)

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The dietary isothiocyanate sulforaphane modulates gene expression and alternative gene splicing in a PTEN null preclinical murine model of prostate cancer

Maria H Traka, Caroline A Spinks, Joanne F Doleman, Antonietta Melchini, Richard Y Ball, Robert D Mills, Richard F Mithen Molecular Cancer 2010, 9:189 (13 July 2010)

The isothiocyanate sulforaphane found at high levels in broccoli modulates PTEN tumor suppressor gene activity and provides further evidence that dietary components could be of benefit in preventing prostate cancer.

Methodology article   Open Access Highly Accessed

ChIP on Chip: surprising results are often artifacts

Torsten Waldminghaus, Kirsten Skarstad BMC Genomics 2010, 11:414 (5 July 2010)

Software   Open Access Highly Accessed

A flexible R package for nonnegative matrix factorization

Renaud Gaujoux, Cathal Seoighe BMC Bioinformatics 2010, 11:367 (2 July 2010)

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Dynamic changes in gene expression in vivo predict prognosis of tamoxifen-treated patients with breast cancer

Karen J Taylor, Andrew H Sims, Liang Liang, Dana Faratian, Morwenna Muir, Graeme Walker, Barbara Kuske, J Michael Dixon, David A Cameron, David J Harrison, Simon P Langdon Breast Cancer Research 2010, 12:R39 (22 June 2010)

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Establishment and characterization of a new human pancreatic adenocarcinoma cell line with high metastatic potential to the lung

Tatyana Kalinina, Cenap Güngör, Sabrina Thieltges, Maren Möller-Krull, Eva Murga Penas, Daniel Wicklein, Thomas Streichert, Udo Schumacher, Viacheslav Kalinin, Ronald Simon, Benjamin Otto, Judith Dierlamm, Heidi Schwarzenbach, Katharina E Effenberger, Maximilian Bockhorn, Jakob R Izbicki, Emre F Yekebas BMC Cancer 2010, 10:295 (16 June 2010)

Research article   Open Access

Muscle transcriptomic profiles in pigs with divergent phenotypes for fatness traits

Angela Cánovas, Raquel Quintanilla, Marcel Amills, Ramona N Pena BMC Genomics 2010, 11:372 (11 June 2010)

Research   Open Access

Response of the mouse lung transcriptome to welding fume: effects of stainless and mild steel fumes on lung gene expression in A/J and C57BL/6J mice

Patti C Zeidler-Erdely, Michael L Kashon, Shengqiao Li, James M Antonini Respiratory Research 2010, 11:70 (3 June 2010)

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Nutrient control of eukaryote cell growth: a systems biology study in yeast

Alex Gutteridge, Pınar Pir, Juan I Castrillo, Philip D Charles, Kathryn S Lilley, Stephen G Oliver BMC Biology 2010, 8:68 (24 May 2010)

In a study on the –omics of yeast cell growth, Stephen Oliver and colleagues measure the response to nutrient deprivation and the global perturbation of the genetic circuitry that accompanies carbon deprivation.

Research article   Open Access

A simple optimization can improve the performance of single feature polymorphism detection by Affymetrix expression arrays

Youko Horiuchi, Yoshiaki Harushima, Hironori Fujisawa, Takako Mochizuki, Masanori Kawakita, Takayuki Sakaguchi, Nori Kurata BMC Genomics 2010, 11:315 (20 May 2010)

Research article   Open Access

Plasmodium infection alters Anopheles gambiae detoxification gene expression

Rute C Félix, Pie Müller, Vera Ribeiro, Hilary Ranson, Henrique Silveira BMC Genomics 2010, 11:312 (19 May 2010)

Methodology article   Open Access

CNstream: A method for the identification and genotyping of copy number polymorphisms using Illumina microarrays

Arnald Alonso, Antonio Julià, Raül Tortosa, Cristina Canaleta, Juan D Cañete, Javier Ballina, Alejandro Balsa, Jesús Tornero, Sara Marsal BMC Bioinformatics 2010, 11:264 (19 May 2010)

Research article   Open Access

Genomic expression and single-nucleotide polymorphism profiling discriminates chromophobe renal cell carcinoma and oncocytoma

Min-Han Tan, Chin Wong, Hwei Tan, Ximing J Yang, Jonathon Ditlev, Daisuke Matsuda, Sok Khoo, Jun Sugimura, Tomoaki Fujioka, Kyle A Furge, Eric Kort, Sophie Giraud, Sophie Ferlicot, Philippe Vielh, Delphine Amsellem-Ouazana, Bernard Debré, Thierry Flam, Nicolas Thiounn, Marc Zerbib, Gérard Benoît, Stéphane Droupy, Vincent Molinié, Annick Vieillefond, Puay Tan, Stéphane Richard, Bin Teh BMC Cancer 2010, 10:196 (12 May 2010)

Methodology article   Open Access Highly Accessed

Consistent annotation of gene expression arrays

Benoît Ballester, Nathan Johnson, Glenn Proctor, Paul Flicek BMC Genomics 2010, 11:294 (11 May 2010)

This article is part of a collection on Ensembl update 2010

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ChIPpeakAnno: a Bioconductor package to annotate ChIP-seq and ChIP-chip data

Lihua J Zhu, Claude Gazin, Nathan D Lawson, Hervé Pagès, Simon M Lin, David S Lapointe, Michael R Green BMC Bioinformatics 2010, 11:237 (11 May 2010)

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A comparison of massively parallel nucleotide sequencing with oligonucleotide microarrays for global transcription profiling

James R Bradford, Yvonne Hey, Tim Yates, Yaoyong Li, Stuart D Pepper, Crispin J Miller BMC Genomics 2010, 11:282 (5 May 2010)

Research   Open Access

The dissection of transcriptional modules regulated by various drugs of abuse in the mouse striatum

Marcin Piechota, Michal Korostynski, Wojciech Solecki, Agnieszka Gieryk, Michal Slezak, Wiktor Bilecki, Barbara Ziolkowska, Elzbieta Kostrzewa, Iwona Cymerman, Lukasz Swiech, Jacek Jaworski, Ryszard Przewlocki Genome Biology 2010, 11:R48 (4 May 2010)

The transcriptional response to six commonly-abused drugs was assessed in the mouse brain revealing common modules of drug-induced genes.

Research article   Open Access

Meta-analysis of archived DNA microarrays identifies genes regulated by hypoxia and involved in a metastatic phenotype in cancer cells

Michael Pierre, Benoît DeHertogh, Anthoula Gaigneaux, Bertrand DeMeulder, Fabrice Berger, Eric Bareke, Carine Michiels, Eric Depiereux BMC Cancer 2010, 10:176 (30 April 2010)

Research article   Open Access

Aryl hydrocarbon receptor (AHR)-regulated transcriptomic changes in rats sensitive or resistant to major dioxin toxicities

Ivy D Moffat, Paul C Boutros, Hanbo Chen, Allan B Okey, Raimo Pohjanvirta BMC Genomics 2010, 11:263 (26 April 2010)

Research article   Open Access

Signal pathways JNK and NF-κB, identified by global gene expression profiling, are involved in regulation of TNFα-induced mPGES-1 and COX-2 expression in gingival fibroblasts

Tove Båge, Johan Lindberg, Joakim Lundeberg, Thomas Modéer, Tülay Yucel-Lindberg BMC Genomics 2010, 11:241 (15 April 2010)

Software   Open Access Highly Accessed

web cellHTS2: A web-application for the analysis of high-throughput screening data

Oliver Pelz, Moritz Gilsdorf, Michael Boutros BMC Bioinformatics 2010, 11:185 (12 April 2010)

Software   Open Access

CNAReporter: a GenePattern pipeline for the generation of clinical reports of genomic alterations

Yuri Kotliarov, Serdar Bozdag, Hangjiong Cheng, Stefan Wuchty, Jean-Claude Zenklusen, Howard A Fine BMC Medical Genomics 2010, 3:11 (9 April 2010)

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GeneMesh: a web-based microarray analysis tool for relating differentially expressed genes to MeSH terms

Saurin D Jani, Gary L Argraves, Jeremy L Barth, W Scott Argraves BMC Bioinformatics 2010, 11:166 (1 April 2010)

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Bacterial diversity at different stages of the composting process

Pasi Partanen, Jenni Hultman, Lars Paulin, Petri Auvinen, Martin Romantschuk BMC Microbiology 2010, 10:94 (29 March 2010)

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Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways

Elgene Lim, Di Wu, Bhupinder Pal, Toula Bouras, Marie-Liesse Asselin-Labat, François Vaillant, Hideo Yagita, Geoffrey J Lindeman, Gordon K Smyth, Jane E Visvader Breast Cancer Research 2010, 12:R21 (26 March 2010)

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Analysing time course microarray data using Bioconductor: a case study using yeast2 Affymetrix arrays

Colin S Gillespie, Guiyuan Lei, Richard J Boys, Amanda Greenall, Darren J Wilkinson BMC Research Notes 2010, 3:81 (19 March 2010)

This article is part of a collection on Microarray normalization...

Research article   Open Access

The embryonic genes Dkk3, Hoxd8, Hoxd9 and Tbx1 identify muscle types in a diet-independent and fiber-type unrelated way

Janneke de Wilde, Martijn FM Hulshof, Mark V Boekschoten, Philip de Groot, Egbert Smit, Edwin CM Mariman BMC Genomics 2010, 11:176 (15 March 2010)

Software   Open Access

XGAP: a uniform and extensible data model and software platform for genotype and phenotype experiments

Morris A Swertz, K Joeri Velde, Bruno M Tesson, Richard A Scheltema, Danny Arends, Gonzalo Vera, Rudi Alberts, Martijn Dijkstra, Paul Schofield, Klaus Schughart, John M Hancock, Damian Smedley, Katy Wolstencroft, Carole Goble, Engbert O de Brock, Andrew R Jones, Helen E Parkinson, Ritsert C Jansen Genome Biology 2010, 11:R27 (9 March 2010)

XGAP, a software platform for the integration and analysis of genotype and phenotype data.

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Promiscuity of enhancer, coding and non-coding transcription functions in ultraconserved elements

Danilo Licastro, Vincenzo A Gennarino, Francesca Petrera, Remo Sanges, Sandro Banfi, Elia Stupka BMC Genomics 2010, 11:151 (4 March 2010)

Method   Open Access Highly Accessed

A scaling normalization method for differential expression analysis of RNA-seq data

Mark D Robinson, Alicia Oshlack Genome Biology 2010, 11:R25 (2 March 2010)

A novel and empirical method for normalization of RNA-seq data is presented

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Modeling expression quantitative trait loci in data combining ethnic populations

Ching-Lin Hsiao, Ie-Bin Lian, Ai-Ru Hsieh, Cathy SJ Fann BMC Bioinformatics 2010, 11:111 (27 February 2010)

Research article   Open Access

Escherichia coli infection induces distinct local and systemic transcriptome responses in the mammary gland

Simone Mitterhuemer, Wolfram Petzl, Stefan Krebs, Daniel Mehne, Andrea Klanner, Eckhard Wolf, Holm Zerbe, Helmut Blum BMC Genomics 2010, 11:138 (25 February 2010)

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Probe set filtering increases correlation between Affymetrix GeneChip and qRT-PCR expression measurements

Jakub Mieczkowski, Magdalena E Tyburczy, Michal Dabrowski, Piotr Pokarowski BMC Bioinformatics 2010, 11:104 (24 February 2010)

Research article   Open Access

Variability of gene expression profiles in human blood and lymphoblastoid cell lines

Josine L Min, Amy Barrett, Tim Watts, Fredrik H Pettersson, Helen E Lockstone, Cecilia M Lindgren, Jennifer M Taylor, Maxine Allen, Krina T Zondervan, Mark I McCarthy BMC Genomics 2010, 11:96 (8 February 2010)

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BABAR: an R package to simplify the normalisation of common reference design microarray-based transcriptomic datasets

Mark J Alston, John Seers, Jay CD Hinton, Sacha Lucchini BMC Bioinformatics 2010, 11:73 (3 February 2010)

Research   Open Access

Candidate genes for alcohol preference identified by expression profiling in alcohol-preferring and -nonpreferring reciprocal congenic rats

Tiebing Liang, Mark W Kimpel, Jeanette N McClintick, Ashley R Skillman, Kevin McCall, Howard J Edenberg, Lucinda G Carr Genome Biology 2010, 11:R11 (3 February 2010)

Transcriptional profiling of specific regions of inbred rat brains reveals genes associated with alcohol preference in a known QTL locus on chromosome 4

Research article   Open Access

Changes in gene expression linked with adult reproductive diapause in a northern malt fly species: a candidate gene microarray study

Maaria Kankare, Tiina Salminen, Asta Laiho, Laura Vesala, Anneli Hoikkala BMC Ecology 2010, 10:3 (1 February 2010)

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Testing for mean and correlation changes in microarray experiments: an application for pathway analysis

Mayer Alvo, Zhongzhu Liu, Andrew Williams, Carole Yauk BMC Bioinformatics 2010, 11:60 (28 January 2010)

Research article   Open Access

Transcriptome analysis reveals absence of unintended effects in drought-tolerant transgenic plants overexpressing the transcription factor ABF3

Ashraf Abdeen, Jaimie Schnell, Brian Miki BMC Genomics 2010, 11:69 (28 January 2010)

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Validation of differential gene expression algorithms: Application comparing fold-change estimation to hypothesis testing

Corey M Yanofsky, David R Bickel BMC Bioinformatics 2010, 11:63 (28 January 2010)

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Processing of Agilent microRNA array data

Pedro López-Romero, Manuel A González, Sergio Callejas, Ana Dopazo, Rafael A Irizarry BMC Research Notes 2010, 3:18 (22 January 2010)

This article is part of a collection on Microarray normalization...

Research article   Open Access

Quantitative model for inferring dynamic regulation of the tumour suppressor gene p53

Junbai Wang, Tianhai Tian BMC Bioinformatics 2010, 11:36 (19 January 2010)

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Gene expression profiling of peripheral blood cells for early detection of breast cancer

Jørgen Aarøe, Torbjørn Lindahl, Vanessa Dumeaux, Solve Sæbø, Derek Tobin, Nina Hagen, Per Skaane, Anders Lönneborg, Praveen Sharma, Anne-Lise Børresen-Dale Breast Cancer Research 2010, 12:R7 (15 January 2010)

Research article   Open Access

Transcriptional adaptations following exercise in Thoroughbred horse skeletal muscle highlights molecular mechanisms that lead to muscle hypertrophy

Beatrice A McGivney, Suzanne S Eivers, David E MacHugh, James N MacLeod, Grace M O'Gorman, Stephen DE Park, Lisa M Katz, Emmeline W Hill BMC Genomics 2009, 10:638 (30 December 2009)

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Correlating measurements across samples improves accuracy of large-scale expression profile experiments

Mariano Alvarez, Pavel Sumazin, Presha Rajbhandari, Andrea Califano Genome Biology 2009, 10:R143 (30 December 2009)

Cleaner is a method for removing uninformative and flawed probes from microarray experiment data, thus improving reproducibility between replicate experiments.

Software   Open Access

TargetSearch - a Bioconductor package for the efficient preprocessing of GC-MS metabolite profiling data

Álvaro Cuadros-Inostroza, Camila Caldana, Henning Redestig, Miyako Kusano, Jan Lisec, Hugo Peña-Cortés, Lothar Willmitzer, Matthew A Hannah BMC Bioinformatics 2009, 10:428 (16 December 2009)

Research article   Open Access

Quantitative comparison of microarray experiments with published leukemia related gene expression signatures

Hans-Ulrich Klein, Christian Ruckert, Alexander Kohlmann, Lars Bullinger, Christian Thiede, Torsten Haferlach, Martin Dugas BMC Bioinformatics 2009, 10:422 (15 December 2009)

Proceedings   Open Access

PutidaNET: Interactome database service and network analysis of Pseudomonas putida KT2440

Seong-Jin Park, Jong-Soon Choi, Byoung-Chul Kim, Seong-Woong Jho, Jea-Woon Ryu, Daeui Park, Kyung-A Lee, Jong Bhak, Seung Il Kim BMC Genomics 2009, 10(Suppl 3):S18 (3 December 2009)

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A comprehensive sensitivity analysis of microarray breast cancer classification under feature variability

Herman MJ Sontrop, Perry D Moerland, René van den Ham, Marcel JT Reinders, Wim FJ Verhaegh BMC Bioinformatics 2009, 10:389 (26 November 2009)

Research article   Open Access

Characterisation of microRNA expression in post-natal mouse mammary gland development

Stefanie Avril-Sassen, Leonard D Goldstein, John Stingl, Cherie Blenkiron, John Le Quesne, Inmaculada Spiteri, Konstantina Karagavriilidou, Christine J Watson, Simon Tavaré, Eric A Miska, Carlos Caldas BMC Genomics 2009, 10:548 (20 November 2009)

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Environmentally-acquired bacteria influence microbial diversity and natural innate immune responses at gut surfaces

Imke E Mulder, Bettina Schmidt, Christopher R Stokes, Marie Lewis, Mick Bailey, Rustam I Aminov, James I Prosser, Bhupinder P Gill, John R Pluske, Claus-Dieter Mayer, Corran C Musk, Denise Kelly BMC Biology 2009, 7:79 (20 November 2009)

Pigs reared indoors or in isolation have a less healthy gut microbiota than outdoor-reared pigs, and signs of immune activation in gut tissues, reinforcing human data associating childhood hygiene with inflammatory bowel disease.

Research article   Open Access

Differentially expressed genes for aggressive pecking behaviour in laying hens

Bart Buitenhuis, Jakob Hedegaard, Luc Janss, Peter Sørensen BMC Genomics 2009, 10:544 (19 November 2009)

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The choroid plexus response to a repeated peripheral inflammatory stimulus

Fernanda Marques, João C Sousa, Giovanni Coppola, Daniel H Geschwind, Nuno Sousa, Joana A Palha, Margarida Correia-Neves BMC Neuroscience 2009, 10:135 (18 November 2009)

Research article   Open Access

Endogenous control genes in complex vascular tissue samples

Lasse Folkersen, Sanela Kurtovic, Anton Razuvaev, Hanna E Agardh, Anders Gabrielsen, Gabrielle Paulsson-Berne BMC Genomics 2009, 10:516 (10 November 2009)

Software   Open Access

ArrayMining: a modular web-application for microarray analysis combining ensemble and consensus methods with cross-study normalization

Enrico Glaab, Jonathan M Garibaldi, Natalio Krasnogor BMC Bioinformatics 2009, 10:358 (28 October 2009)

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Genetical genomic determinants of alcohol consumption in rats and humans

Boris Tabakoff, Laura Saba, Morton Printz, Pam Flodman, Colin Hodgkinson, David Goldman, George Koob, Heather N Richardson, Katerina Kechris, Richard L Bell, Norbert Hübner, Matthias Heinig, Michal Pravenec, Jonathan Mangion, Lucie Legault, Maurice Dongier, Katherine M Conigrave, John B Whitfield, John Saunders, Bridget Grant, Paula L Hoffman, BMC Biology 2009, 7:70 (27 October 2009)

Genetic pathways involving appetite, satiety and reward affect alcohol consumption in rats and humans, specifically GABAergic and dopaminergic signaling, but genes in these pathways are not linked to alcohol dependence or abuse in people.

Research article   Open Access

Expulsion of Trichuris muris is associated with increased expression of angiogenin 4 in the gut and increased acidity of mucins within the goblet cell

Riccardo D'Elia, Matthew L deSchoolmeester, Leo AH Zeef, Steven H Wright, Alan D Pemberton, Kathryn J Else BMC Genomics 2009, 10:492 (24 October 2009)

Research article   Open Access

Comparative transcriptional survey between laser-microdissected cells from laminar abscission zone and petiolar cortical tissue during ethylene-promoted abscission in citrus leaves

Javier Agustí, Paz Merelo, Manuel Cercós, Francisco R Tadeo, Manuel Talón BMC Plant Biology 2009, 9:127 (23 October 2009)

Research   Open Access

Differential effects of cytokines and corticosteroids on Toll-like receptor 2 expression and activity in human airway epithelia

Audra A Winder, Christine Wohlford-Lenane, Todd E Scheetz, Brie N Nardy, Lori J Manzel, Dwight C Look, Paul B McCray Respiratory Research 2009, 10:96 (16 October 2009)

Research   Open Access

Survival Online: a web-based service for the analysis of correlations between gene expression and clinical and follow-up data

Luca Corradi, Valentina Mirisola, Ivan Porro, Livia Torterolo, Marco Fato, Paolo Romano, Ulrich Pfeffer BMC Bioinformatics 2009, 10(Suppl 12):S10 (15 October 2009)

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An oligo-based microarray offers novel transcriptomic approaches for the analysis of pathogen resistance and fruit quality traits in melon (Cucumis melo L.)

Albert Mascarell-Creus, Joaquin Cañizares, Josep Vilarrasa-Blasi, Santiago Mora-García, José Blanca, Daniel Gonzalez-Ibeas, Montserrat Saladié, Cristina Roig, Wim Deleu, Belén Picó-Silvent, Nuria López-Bigas, Miguel A Aranda, Jordi Garcia-Mas, Fernando Nuez, Pere Puigdomènech, Ana I Caño-Delgado BMC Genomics 2009, 10:467 (12 October 2009)

An oligo-based microarray derived from over 30,000 melon (Cucumis melo) ESTs provides a platform for the functional genomic study of experimental conditions such as fruit quality and response to viral and fungal infections.

Research article   Open Access

Oligonucleotide array discovery of polymorphisms in cultivated tomato (Solanum lycopersicum L.) reveals patterns of SNP variation associated with breeding

Sung-Chur Sim, Matthew D Robbins, Charles Chilcott, Tong Zhu, David M Francis BMC Genomics 2009, 10:466 (9 October 2009)

Proceedings   Open Access

Threshold selection in gene co-expression networks using spectral graph theory techniques

Andy D Perkins, Michael A Langston BMC Bioinformatics 2009, 10(Suppl 11):S4 (8 October 2009)

Research article   Open Access

Robust extraction of functional signals from gene set analysis using a generalized threshold free scoring function

Petri Törönen, Pauli J Ojala, Pekka Marttinen, Liisa Holm BMC Bioinformatics 2009, 10:307 (23 September 2009)

Research article   Open Access

Mapping of HNF4α target genes in intestinal epithelial cells

Mette Boyd, Simon Bressendorff, Jette Møller, Jørgen Olsen, Jesper T Troelsen BMC Gastroenterology 2009, 9:68 (17 September 2009)

Proceedings   Open Access

Mechanism-anchored profiling derived from epigenetic networks predicts outcome in acute lymphoblastic leukemia

Xinan Yang, Yong Huang, James L Chen, Jianming Xie, Xiao Sun, Yves A Lussier BMC Bioinformatics 2009, 10(Suppl 9):S6 (17 September 2009)

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Reciprocal regulation of microRNA and mRNA profiles in neuronal development and synapse formation

Sergei A Manakov, Seth GN Grant, Anton J Enright BMC Genomics 2009, 10:419 (8 September 2009)

Debate   Open Access

A cross-study gene set enrichment analysis identifies critical pathways in endometriosis

Hongbo Zhao, Qishan Wang, Chunyan Bai, Kan He, Yuchun Pan Reproductive Biology and Endocrinology 2009, 7:94 (8 September 2009)

Research   Open Access Highly Accessed

Meta-analysis of glioblastoma multiforme versus anaplastic astrocytoma identifies robust gene markers

Jonathan M Dreyfuss, Mark D Johnson, Peter J Park Molecular Cancer 2009, 8:71 (4 September 2009)

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Molecular mechanisms of tungstate-induced pancreatic plasticity: a transcriptomics approach

Jordi Altirriba, Albert Barbera, Héctor Del Zotto, Belen Nadal, Sandra Piquer, Alex Sánchez-Pla, Juan J Gagliardino, Ramon Gomis BMC Genomics 2009, 10:406 (28 August 2009)

Sodium tungstate acts via several glycemia-independent pathways to induce pancreatic beta cell proliferation in a rat model of diabetes, with the MAPK pathway playing a key role.

Software   Open Access

dictyExpress: a Dictyostelium discoideum gene expression database with an explorative data analysis web-based interface

Gregor Rot, Anup Parikh, Tomaz Curk, Adam Kuspa, Gad Shaulsky, Blaz Zupan BMC Bioinformatics 2009, 10:265 (25 August 2009)

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MicroRNA-125a is over-expressed in insulin target tissues in a spontaneous rat model of Type 2 Diabetes

Blanca M Herrera, Helen E Lockstone, Jennifer M Taylor, Quin F Wills, Pamela J Kaisaki, Amy Barrett, Carme Camps, Christina Fernandez, Jiannis Ragoussis, Dominique Gauguier, Mark I McCarthy, Cecilia M Lindgren BMC Medical Genomics 2009, 2:54 (18 August 2009)

Combining global microRNA and mRNA expression data indicates MiR-125a is over-expressed in the liver of hyperglycaemic rats and is a putative modulator of glucose and lipid metabolism in a rat model of type 2 diabetes.

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Computational identification of hepatitis C virus associated microRNA-mRNA regulatory modules in human livers

Xinxia Peng, Yu Li, Kathie-Anne Walters, Elizabeth R Rosenzweig, Sharon L Lederer, Lauri D Aicher, Sean Proll, Michael G Katze BMC Genomics 2009, 10:373 (11 August 2009)

Research article   Open Access

Grapevine cell early activation of specific responses to DIMEB, a resveratrol elicitor

Anita Zamboni, Pamela Gatto, Alessandro Cestaro, Stefania Pilati, Roberto Viola, Fulvio Mattivi, Claudio Moser, Riccardo Velasco BMC Genomics 2009, 10:363 (6 August 2009)

Methodology article   Open Access Highly Accessed

Improving detection of differentially expressed gene sets by applying cluster enrichment analysis to Gene Ontology

Tao Xu, JianLei Gu, Yan Zhou, LinFang Du BMC Bioinformatics 2009, 10:240 (5 August 2009)

Research article   Open Access Highly Accessed

Gene copy number variation throughout the Plasmodium falciparum genome

Ian H Cheeseman, Natalia Gomez-Escobar, Celine K Carret, Alasdair Ivens, Lindsay B Stewart, Kevin KA Tetteh, David J Conway BMC Genomics 2009, 10:353 (4 August 2009)

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Characterization of the Zoarces viviparus liver transcriptome using massively parallel pyrosequencing

Erik Kristiansson, Noomi Asker, Lars Förlin, DG Joakim Larsson BMC Genomics 2009, 10:345 (31 July 2009)

Research article   Open Access

Gene expression profile of rat left ventricles reveals persisting changes following chronic mild exercise protocol: implications for cardioprotection

Betti Giusti, Marina Marini, Luciana Rossi, Ilaria Lapini, Alberto Magi, Andrea Capalbo, Rosa Lapalombella, Simona di Tullio, Michele Samaja, Fabio Esposito, Vittoria Margonato, Maria Boddi, Rosanna Abbate, Arsenio Veicsteinas BMC Genomics 2009, 10:342 (30 July 2009)

Software   Open Access Highly Accessed

TableButler – a Windows based tool for processing large data tables generated with high-throughput methods

Christian Schwager, Ute Wirkner, Amir Abdollahi, Peter E Huber BMC Bioinformatics 2009, 10:235 (29 July 2009)

Methodology article   Open Access Highly Accessed

CLEAN: CLustering Enrichment ANalysis

Johannes M Freudenberg, Vineet K Joshi, Zhen Hu, Mario Medvedovic BMC Bioinformatics 2009, 10:234 (29 July 2009)

Method   Open Access Highly Accessed

Probe-level estimation improves the detection of differential splicing in Affymetrix exon array studies

Essi Laajala, Tero Aittokallio, Riitta Lahesmaa, Laura L Elo Genome Biology 2009, 10:R77 (16 July 2009)

A novel statistical procedure is presented that uses probe-level information on Affymetrix exon arrays to detect differential splicing.

Research   Open Access

Microarray data mining using Bioconductor packages

Haisheng Nie, Pieter BT Neerincx, Jan Poel, Francesco Ferrari, Silvio Bicciato, Jack AM Leunissen, Martien AM Groenen BMC Proceedings 2009, 3(Suppl 4):S9 (16 July 2009)

Research   Open Access

Gene set analysis methods applied to chicken microarray expression data

Axel Skarman, Li Jiang, Henrik Hornshøj, Bart Buitenhuis, Jakob Hedegaard, Lene N Conley, Peter Sørensen BMC Proceedings 2009, 3(Suppl 4):S8 (16 July 2009)

Research   Open Access

Comparison of three microarray probe annotation pipelines: differences in strategies and their effect on downstream analysis

Pieter BT Neerincx, Pierrot Casel, Dennis Prickett, Haisheng Nie, Michael Watson, Jack AM Leunissen, Martien AM Groenen, Christophe Klopp BMC Proceedings 2009, 3(Suppl 4):S1 (16 July 2009)

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Evolution of plant senescence

Howard Thomas, Lin Huang, Mike Young, Helen Ougham BMC Evolutionary Biology 2009, 9:163 (14 July 2009)

Research article   Open Access

Finding exclusively deleted or amplified genomic areas in lung adenocarcinomas using a novel chromosomal pattern analysis

Philippe Broët, Patrick Tan, Marco Alifano, Sophie Camilleri-Broët, Sylvia Richardson BMC Medical Genomics 2009, 2:43 (14 July 2009)

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Genomic profiling of breast tumours in relation to BRCA abnormalities and phenotypes

Olafur Stefansson, Jon Jonasson, Oskar Johannsson, Kristrun Olafsdottir, Margret Steinarsdottir, Sigridur Valgeirsdottir, Jorunn Eyfjord Breast Cancer Research 2009, 11:R47 (9 July 2009)

Research   Open Access

A distribution-free convolution model for background correction of oligonucleotide microarray data

Zhongxue Chen, Monnie McGee, Qingzhong Liu, Megan Kong, Youping Deng, Richard H Scheuermann BMC Genomics 2009, 10(Suppl 1):S19 (7 July 2009)

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Sequence diversity in three tomato species: SNPs, markers, and molecular evolution

José M Jiménez-Gómez, Julin N Maloof BMC Plant Biology 2009, 9:85 (3 July 2009)

Analysis of the available expressed sequence tags (ESTs) for one cultivated and two wild tomato species highlights sets of genes and polymorphisms with potential significance for the evolution and domestication of this important crop.

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Unsupervised assessment of microarray data quality using a Gaussian mixture model

Brian E Howard, Beate Sick, Steffen Heber BMC Bioinformatics 2009, 10:191 (22 June 2009)

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The development of a comparison approach for Illumina bead chips unravels unexpected challenges applying newest generation microarrays

Daniela Eggle, Svenja Debey-Pascher, Marc Beyer, Joachim L Schultze BMC Bioinformatics 2009, 10:186 (18 June 2009)

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Host cell transcriptional profiling during malaria liver stage infection reveals a coordinated and sequential set of biological events

Sónia S Albuquerque, Céline Carret, Ana Grosso, Alice S Tarun, Xinxia Peng, Stefan HI Kappe, Miguel Prudêncio, Maria M Mota BMC Genomics 2009, 10:270 (17 June 2009)

Proceedings   Open Access

Expression pattern divergence of duplicated genes in rice

Zhe Li, He Zhang, Song Ge, Xiaocheng Gu, Ge Gao, Jingchu Luo BMC Bioinformatics 2009, 10(Suppl 6):S8 (16 June 2009)

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Integrated analysis of DNA methylation and gene expression reveals specific signaling pathways associated with platinum resistance in ovarian cancer

Meng Li, Curt Balch, John S Montgomery, Mikyoung Jeong, Jae Chung, Pearlly Yan, Tim HM Huang, Sun Kim, Kenneth P Nephew BMC Medical Genomics 2009, 2:34 (8 June 2009)

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Large-scale analysis of antisense transcription in wheat using the Affymetrix GeneChip Wheat Genome Array

Tristan E Coram, Matthew L Settles, Xianming Chen BMC Genomics 2009, 10:253 (29 May 2009)

Research article   Open Access

Identification of gene co-regulatory modules and associated cis-elements involved in degenerative heart disease

Charles G Danko, Arkady M Pertsov BMC Medical Genomics 2009, 2:31 (28 May 2009)

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Gene expression during Drosophila melanogaster egg development before and after reproductive diapause

Dean A Baker, Steven Russell BMC Genomics 2009, 10:242 (24 May 2009)

Methodology article   Open Access Highly Accessed

Differential splicing using whole-transcript microarrays

Mark D Robinson, Terence P Speed BMC Bioinformatics 2009, 10:156 (22 May 2009)

The Affymetrix GeneChip microarray platform, widely used to assay gene expression, can also detect differential splicing events with the help of a new statistical method called FIRMAGene that analyses information from poorly fitting adjacent probes.

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Gene expression in the prefrontal cortex during adolescence: implications for the onset of schizophrenia

Laura W Harris, Helen E Lockstone, Phillipp Khaitovich, Cynthia Weickert, Maree J Webster, Sabine Bahn BMC Medical Genomics 2009, 2:28 (20 May 2009)

Database   Open Access Highly Accessed

MIMAS 3.0 is a Multiomics Information Management and Annotation System

Alexandre Gattiker, Leandro Hermida, Robin Liechti, Ioannis Xenarios, Olivier Collin, Jacques Rougemont, Michael Primig BMC Bioinformatics 2009, 10:151 (18 May 2009)

An international collaboration of software developers, computer scientists, life scientists and research technicians has extended a database tool that manages microarray data from various sources to include data from the latest ultra-high throughput DNA sequencing technologies.

Software   Open Access

flowClust: a Bioconductor package for automated gating of flow cytometry data

Kenneth Lo, Florian Hahne, Ryan R Brinkman, Raphael Gottardo BMC Bioinformatics 2009, 10:145 (14 May 2009)

Research   Open Access

Classification-based comparison of pre-processing methods for interpretation of mass spectrometry generated clinical datasets

Wouter Wegdam, Perry D Moerland, Marrije R Buist, Emiel van Themaat, Boris Bleijlevens, Huub CJ Hoefsloot, Chris G de Koster, Johannes MFG Aerts Proteome Science 2009, 7:19 (14 May 2009)

Research article   Open Access

Similar gene expression profiles of sporadic, PGL2-, and SDHD-linked paragangliomas suggest a common pathway to tumorigenesis

Erik F Hensen, Jelle J Goeman, Jan Oosting, Andel GL Van der Mey, Pancras CW Hogendoorn, Cor WRJ Cremers, Peter Devilee, Cees J Cornelisse BMC Medical Genomics 2009, 2:25 (11 May 2009)

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Insights into the regulation of intrinsically disordered proteins in the human proteome by analyzing sequence and gene expression data

Yvonne JK Edwards, Anna E Lobley, Melissa M Pentony, David T Jones Genome Biology 2009, 10:R50 (11 May 2009)

Signals for microRNA targeting and ubiquitination are enriched in intrinsically disordered proteins, but some highly disordered proteins can escape rapid degradation.

Short Report   Open Access

Differential gene expression signatures for cell wall integrity found in chitin synthase II (chs2Δ) and myosin II (myo1Δ) deficient cytokinesis mutants of Saccharomyces cerevisiae

José F Rodríguez-Quiñones, José R Rodríguez-Medina BMC Research Notes 2009, 2:87 (9 May 2009)

Research   Open Access

Systemic analysis of the response of Aspergillus niger to ambient pH

Mikael R Andersen, Linda Lehmann, Jens Nielsen Genome Biology 2009, 10:R47 (1 May 2009)

Systems modeling of Aspergillus niger under different pH conditions reveals novel pH-regulated metabolic genes and signaling genes in the pal/pacC pathway.

Research   Open Access Highly Accessed

Ranking differentially expressed genes from Affymetrix gene expression data: methods with reproducibility, sensitivity, and specificity

Koji Kadota, Yuji Nakai, Kentaro Shimizu Algorithms for Molecular Biology 2009, 4:7 (22 April 2009)

Software   Open Access Highly Accessed

flowCore: a Bioconductor package for high throughput flow cytometry

Florian Hahne, Nolwenn LeMeur, Ryan R Brinkman, Byron Ellis, Perry Haaland, Deepayan Sarkar, Josef Spidlen, Errol Strain, Robert Gentleman BMC Bioinformatics 2009, 10:106 (9 April 2009)

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Expression profile and transcription factor binding site exploration of imprinted genes in human and mouse

Christine Steinhoff, Martina Paulsen, Szymon Kielbasa, Jörn Walter, Martin Vingron BMC Genomics 2009, 10:144 (31 March 2009)

Research article   Open Access

QPRT: a potential marker for follicular thyroid carcinoma including minimal invasive variant; a gene expression, RNA and immunohistochemical study

Nora Hinsch, Matthias Frank, Claudia Döring, Christian Vorländer, Martin-Leo Hansmann BMC Cancer 2009, 9:93 (26 March 2009)

Methodology article   Open Access

Detection of genomic deletions in rice using oligonucleotide microarrays

Myron Bruce, Ann Hess, Jianfa Bai, Ramil Mauleon, M Genaleen Diaz, Nobuko Sugiyama, Alicia Bordeos, Guo-Liang Wang, Hei Leung, Jan E Leach BMC Genomics 2009, 10:129 (25 March 2009)

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MicroRNA and gene expression patterns in the differentiation of human embryonic stem cells

Jiaqiang Ren, Ping Jin, Ena Wang, Francesco M Marincola, David F Stroncek Journal of Translational Medicine 2009, 7:20 (23 March 2009)

Research article   Open Access

Cbf genes of the Fr-A2 allele are differentially regulated between long-term cold acclimated crown tissue of freeze-resistant and – susceptible, winter wheat mutant lines

Fedora Sutton, Ding-Geng Chen, Xijin Ge, Don Kenefick BMC Plant Biology 2009, 9:34 (23 March 2009)

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Expression-based discovery of candidate ovule development regulators through transcriptional profiling of ovule mutants

Debra J Skinner, Charles S Gasser BMC Plant Biology 2009, 9:29 (16 March 2009)

Comparison of Arabidopsis mutants 'inner no outer' and 'aintegumenta' with wild-type using microarray analysis identified candidate genes expressed specifically in the integuments of ovules providing a useful resource for functional analysis.

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Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo

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