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Bioconductor: open software development for computational biology and bioinformatics

Robert C Gentleman1 email, Vincent J Carey2 email, Douglas M Bates3 email, Ben Bolstad4 email, Marcel Dettling5 email, Sandrine Dudoit4 email, Byron Ellis6 email, Laurent Gautier7 email, Yongchao Ge8 email, Jeff Gentry1, Kurt Hornik9, Torsten Hothorn10, Wolfgang Huber11, Stefano Iacus12, Rafael Irizarry13, Friedrich Leisch9, Cheng Li1, Martin Maechler5, Anthony J Rossini14, Gunther Sawitzki15, Colin Smith16, Gordon Smyth17, Luke Tierney18, Jean YH Yang19 and Jianhua Zhang1

1Department of Biostatistical Science, Dana-Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA

2Channing Laboratory, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA

3Department of Statistics, University of Wisconsin-Madison, 1210 W Dayton St, Madison, WI 53706, USA

4Division of Biostatistics, University of California, Berkeley, 140 Warren Hall, Berkeley, CA 94720-7360, USA

5Seminar for Statistics LEO C16, ETH Zentrum, Zürich CH-8092, Switzerl

6Department of Statistics, Harvard University, 1 Oxford St, Cambridge, MA 02138, USA

7Center for Biological Sequence Analysis, Technical University of Denmark, Building 208, Lyngby 2800, Denmark

8Department of Biomathematical Sciences, Mount Sinai School of Medicine, 1 Gustave Levy Place, Box 1023, New York, NY 10029, USA

9Institut für Statistik und Wahrscheinlichkeitstheorie, TU Wien, Wiedner Hauptstrasse 8-10/1071, Wien 1040, Austria

10Institut für Medizininformatik, Biometrie und Epidemiologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Waldstraße6, D-91054 Erlangen, Germany

11Division of Molecular Genome Analysis, DKFZ (German Cancer Research Center), 69120 Heidelberg, Germany

12Department of Economics, University of Milan, 23 Via Mercalli, I-20123 Milan, Italy

13Department of Biostatistics, Johns Hopkins University, 615 N Wolfe St E3035, Baltimore, MD 21205, USA

14Department of Medical Education and Biomedical Informatics, University of Washington, Box 357240, 1959 NE Pacific, Seattle, WA 98195, USA

15Statistisches Labor, Institut für Angewandte Mathematik, Im Neuenheimer Feld 294, D 69120, Heidelberg, Germany

16Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, TPC-28, La Jolla, CA 92037, USA

17Division of Genetics and Bioinformatics, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia

18Department of Statistics and Actuarial Science, University of Iowa, 241 Schaeffer Hall, Iowa City, IA 52242, USA

19Center for Bioinformatics and Molecular Biostatistics, Univerisity of California, San Francisco, 500 Parnassus Ave, San Francisco 94143-0560, USA

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Genome Biology 2004, 5:R80doi:10.1186/gb-2004-5-10-r80

Published: 15 September 2004

Subject areas: Bioinformatics, Methods

Abstract

The Bioconductor project is an initiative for the collaborative creation of extensible software for computational biology and bioinformatics. The goals of the project include: fostering collaborative development and widespread use of innovative software, reducing barriers to entry into interdisciplinary scientific research, and promoting the achievement of remote reproducibility of research results. We describe details of our aims and methods, identify current challenges, compare Bioconductor to other open bioinformatics projects, and provide working examples.


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