Proposed reaction mechanism for HMGRP [7,18]. The side groups of the key catalytic residues, Lys267, Asp283, Glu83, and His381, are shown, and the substrate and products are shown with R representing the HMG portion. The reaction follows three stages (see text for details). A basically similar mechanism has been proposed for HMGRH .
Friesen and Rodwell Genome Biology 2004 5:248 doi:10.1186/gb-2004-5-11-248