Genomic transcriptional response to loss of chromosomal supercoiling in Escherichia coli

Brian J Peter^1,6 , Javier Arsuaga^1,2, Adam M Breier³, Arkady B Khodursky⁴, Patrick O Brown⁵ and Nicholas R Cozzarelli¹

¹Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720-3204, USA

²Mathematics Department, University of California, Berkeley, CA 94720, USA

³Graduate Group in Biophysics, University of California, Berkeley, CA 94720, USA

⁴Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, St. Paul, MN 55108, USA

⁵Department of Biochemistry and Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305-5307, USA

⁶Current address: Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge CB2 2QH, UK