Table 4

Statistical significance of the overall analysis of coexpression, common 5' regulatory motifs, homogeneity in dispensability and lethality for the phylogenetically distinct module cores

Function

P-exp

P-mot

P-hom

P-let

p-core

p-net

Cell fate

<0.05

-

-

<0.05

0.28

0.08

Energy

-

<.005

-

-

0

0.05

Metabolism

<0.0005

<0.05

-

<0.01

0.14

0.08

Cellular transport

-

-

< 0.01

-

None

0.28

Cell cycle

<0.05

-

< 0.05

0.0001

0.35

0.29

Protein fate

<0.0005

-

-

-

0.41

0.16

Transport facilitation

-

-

-

-

0.5

0.15

Cell environment

-

-

-

<0.05

0

0.06

Protein synthesis

<0.05

-

< 0.0005

0.0001

0.2

0.06

Cell rescue

<0.05

-

-

-

0

0.12

Signaling

-

-

-

-

0

0.12

Cell organization

<0.01

<0.05

-

-

0.08

0.12

Transcription

<0.05

<0.01

<0.01

<0.001

0.68

0.3

Statistical significance (P-values), of the overall analysis of coexpression (P-exp), common 5' regulatory motifs (P-mot), homogeneity in dispensability (P-hom) and lethality (P-let), for the phylogenetically distinct module cores (see text and Materials and methods for details). Not significant statistical results are denoted by -. p-core is the probability of finding lethal genes in the set of proteins without human homolog belonging to the significant cores. p-net is the probability of finding lethal genes in those proteins not found in humans which are part of each full network.

Poyatos and Hurst Genome Biology 2004 5:R93   doi:10.1186/gb-2004-5-11-r93