Table 1

Functions of Jaks

Gene

Phenotype of mouse knockout

Cytokines whose signaling requires this Jak

Jak1

Viable but early postnatal lethal owing to neurological deficits; SCID

Families of receptor with the shared subunits γc or gp130; IFNs

Jak2

Embryonic lethal owing to a defect of erythropoiesis

IL-3; family of receptors with the shared subunit gp130; IFN-γ hormone-like cytokines (EPO, GH, PRL, TPO)

Jak3

SCID, viable and fertile

Family of receptor with the shared subunit γc

Tyk2

Viable and fertile; susceptible to parasite infection; resistant to LPS; resistant to collagen-induced arthritis

IL-12; LPS

Abbreviations: EPO, erythropoietin; γc, common γ chain; GH, growth hormone; IFN, interferon; IL, interleukin; LPS, bacterial lipopolysaccharide; PRL, prolactin; SCID, severe combined immunodeficiency; TPO, thrombopoietin.

Yamaoka et al. Genome Biology 2004 5:253   doi:10.1186/gb-2004-5-12-253