Table 1 |
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Functions of Jaks |
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| Gene |
Phenotype of mouse knockout |
Cytokines whose signaling requires this Jak |
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| Jak1 |
Viable but early postnatal lethal owing to neurological deficits; SCID |
Families of receptor with the shared subunits γc or gp130; IFNs |
| Jak2 |
Embryonic lethal owing to a defect of erythropoiesis |
IL-3; family of receptors with the shared subunit gp130; IFN-γ hormone-like cytokines
(EPO, GH, PRL, TPO) |
| Jak3 |
SCID, viable and fertile |
Family of receptor with the shared subunit γc |
| Tyk2 |
Viable and fertile; susceptible to parasite infection; resistant to LPS; resistant
to collagen-induced arthritis |
IL-12; LPS |
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Abbreviations: EPO, erythropoietin; γc, common γ chain; GH, growth hormone; IFN, interferon; IL, interleukin; LPS, bacterial lipopolysaccharide; PRL, prolactin; SCID, severe combined immunodeficiency; TPO, thrombopoietin. |
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Yamaoka et al. Genome Biology 2004 5:253 doi:10.1186/gb-2004-5-12-253 |
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