Genome Biology

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GOToolBox: functional analysis of gene datasets based on Gene Ontology

David Martin*, Christine Brun, Elisabeth Remy, Pierre Mouren, Denis Thieffry and Bernard Jacq

Genome Biology 2004, 5:R101 doi:10.1186/gb-2004-5-12-r101

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BioMed Central: 33 citations

Research article   Open Access

SND2, a NAC transcription factor gene, regulates genes involved in secondary cell wall development in Arabidopsis fibres and increases fibre cell area in Eucalyptus

Steven G Hussey, Eshchar Mizrachi, Antanas V Spokevicius, Gerd Bossinger, Dave K Berger, Alexander A Myburg BMC Plant Biology 2011, 11:173 (1 December 2011)

Research article   Open Access Highly Accessed

Nutrigenomics in honey bees: digital gene expression analysis of pollen's nutritive effects on healthy and varroa-parasitized bees

Cédric Alaux, Christelle Dantec, Hughes Parrinello, Yves Le Conte BMC Genomics 2011, 12:496 (10 October 2011)

Research article   Open Access

Revealing and avoiding bias in semantic similarity scores for protein pairs

Jing Wang, Xianxiao Zhou, Jing Zhu, Chenggui Zhou, Zheng Guo BMC Bioinformatics 2010, 11:290 (28 May 2010)

Research article   Open Access

Identifying overrepresented concepts in gene lists from literature: a statistical approach based on Poisson mixture model

Xin He, Moushumi Sarma, Xu Ling, Brant Chee, Chengxiang Zhai, Bruce Schatz BMC Bioinformatics 2010, 11:272 (20 May 2010)

Method   Open Access Highly Accessed

Gene ontology analysis for RNA-seq: accounting for selection bias

Matthew D Young, Matthew J Wakefield, Gordon K Smyth, Alicia Oshlack Genome Biology 2010, 11:R14 (4 February 2010)

GOseq is a method for GO analysis of RNA-seq data that takes into account the length bias inherent in RNA-seq

Proceedings   Open Access

Graph ranking for exploratory gene data analysis

Cuilan Gao, Xin Dang, Yixin Chen, Dawn Wilkins BMC Bioinformatics 2009, 10(Suppl 11):S19 (8 October 2009)

Research   Open Access Highly Accessed

A polynomial time biclustering algorithm for finding approximate expression patterns in gene expression time series

Sara C Madeira, Arlindo L Oliveira Algorithms for Molecular Biology 2009, 4:8 (4 June 2009)

Research article   Open Access

A Drosophila systems model of pentylenetetrazole induced locomotor plasticity responsive to antiepileptic drugs

Farhan Mohammad, Priyanka Singh, Abhay Sharma BMC Systems Biology 2009, 3:11 (21 January 2009)

Method   Open Access Highly Accessed

KEGG spider: interpretation of genomics data in the context of the global gene metabolic network

Alexey V Antonov, Sabine Dietmann, Hans W Mewes Genome Biology 2008, 9:R179 (18 December 2008)

A web-based tool for interpretation of experimentally-derived gene lists that provides global models uniting genes from different metabolic pathways.

Methodology article   Open Access Highly Accessed

Assessment of protein set coherence using functional annotations

Monica Chagoyen, Jose M Carazo, Alberto Pascual-Montano BMC Bioinformatics 2008, 9:444 (20 October 2008)

A novel approach to evaluating the homogeneity of protein sets on the basis of the global similarity of their Gene Ontology functional annotations compliments methods for validating microarray clusters and protein-protein interaction networks.

Methodology article   Open Access Highly Accessed

Integration of relational and hierarchical network information for protein function prediction

Xiaoyu Jiang, Naoki Nariai, Martin Steffen, Simon Kasif, Eric D Kolaczyk BMC Bioinformatics 2008, 9:350 (22 August 2008)

Research article   Open Access Highly Accessed

Gene Ontology term overlap as a measure of gene functional similarity

Meeta Mistry, Paul Pavlidis BMC Bioinformatics 2008, 9:327 (4 August 2008)

Research article   Open Access

Defining a Modular Signalling Network from the Fly Interactome

Anaïs Baudot, Jean-Baptiste Angelelli, Alain Guénoche, Bernard Jacq, Christine Brun BMC Systems Biology 2008, 2:45 (19 May 2008)

Method   Open Access

Simplified ontologies allowing comparison of developmental mammalian gene expression

Adele Kruger, Oliver Hofmann, Piero Carninci, Yoshihide Hayashizaki, Winston Hide Genome Biology 2007, 8:R229 (25 October 2007)

The Developmental eVOC ontologies presented are simplified orthogonal ontologies describing the temporal and spatial distribution of developmental human and mouse anatomy.

Research article   Open Access Highly Accessed

Comparison of the contributions of the nuclear and cytoplasmic compartments to global gene expression in human cells

Roger A Barthelson, Georgina M Lambert, Cheryl Vanier, Ronald M Lynch, David W Galbraith BMC Genomics 2007, 8:340 (25 September 2007)

Method   Open Access

The LeFE algorithm: embracing the complexity of gene expression in the interpretation of microarray data

Gabriel S Eichler, Mark Reimers, David Kane, John N Weinstein Genome Biology 2007, 8:R187 (10 September 2007)

The LeFE algorithm has been developed to address the complex, non-linear regulation of gene expression.

Software   Open Access Highly Accessed

The DAVID Gene Functional Classification Tool: a novel biological module-centric algorithm to functionally analyze large gene lists

Da Huang, Brad T Sherman, Qina Tan, Jack R Collins, W Gregory Alvord, Jean Roayaei, Robert Stephens, Michael W Baseler, H Clifford Lane, Richard A Lempicki Genome Biology 2007, 8:R183 (4 September 2007)

The DAVID gene functional classification tool uses a novel fuzzy clustering algorithm to condense a list of genes or associated biological terms into organized classes of related genes or biology, called biological modules.

Research article   Open Access

Gene analogue finder: a GRID solution for finding functionally analogous gene products

Angelica Tulipano, Giacinto Donvito, Flavio Licciulli, Giorgio Maggi, Andreas Gisel BMC Bioinformatics 2007, 8:329 (3 September 2007)

Database   Open Access Highly Accessed

EasyGO: Gene Ontology-based annotation and functional enrichment analysis tool for agronomical species

Xin Zhou, Zhen Su BMC Genomics 2007, 8:246 (24 July 2007)

Research article   Open Access

Species differences in brain gene expression profiles associated with adult behavioral maturation in honey bees

Moushumi Sen Sarma, Charles W Whitfield, Gene E Robinson BMC Genomics 2007, 8:202 (29 June 2007)

Poster presentation   Open Access

A global statistical test for improved detection of gene activity

David JG Bakewell, Ernst Wit BMC Systems Biology 2007, 1(Suppl 1):P10 (8 May 2007)

Research article   Open Access

Thermal evolution of gene expression profiles in Drosophila subobscura

Hafid Laayouni, Francisco García-Franco, Blanca E Chávez-Sandoval, Vincenzo Trotta, Sergi Beltran, Montserrat Corominas, Mauro Santos BMC Evolutionary Biology 2007, 7:42 (19 March 2007)

Research article   Open Access

Conservation of noncoding microsatellites in plants: implication for gene regulation

Lida Zhang, Kaijing Zuo, Fei Zhang, Youfang Cao, Jiang Wang, Yidong Zhang, Xiaofen Sun, Kexuan Tang BMC Genomics 2006, 7:323 (25 December 2006)

Research article   Open Access

The homeobox transcription factor Even-skipped regulates acquisition of electrical properties in Drosophila neurons

Edward CG Pym, Tony D Southall, Christopher J Mee, Andrea H Brand, Richard A Baines Neural Development 2006, 1:3 (16 November 2006)

Research article   Open Access Highly Accessed

Topological basis of signal integration in the transcriptional-regulatory network of the yeast, Saccharomyces cerevisiae

Illés J Farkas, Chuang Wu, Chakra Chennubhotla, Ivet Bahar, Zoltán N Oltvai BMC Bioinformatics 2006, 7:478 (28 October 2006)

Software   Open Access Highly Accessed

TreeDyn: towards dynamic graphics and annotations for analyses of trees

François Chevenet, Christine Brun, Anne-Laure Bañuls, Bernard Jacq, Richard Christen BMC Bioinformatics 2006, 7:439 (10 October 2006)

The open source TreeDyn tool eliminates the need for laborious manual analysis of phylogenetic and similar trees, providing easy manipulation and annotation of multiple trees.

Methodology article   Open Access Highly Accessed

A literature-based similarity metric for biological processes

Monica Chagoyen, Pedro Carmona-Saez, Concha Gil, Jose M Carazo, Alberto Pascual-Montano BMC Bioinformatics 2006, 7:363 (26 July 2006)

Research   Open Access Highly Accessed

Evolution of candidate transcriptional regulatory motifs since the human-chimpanzee divergence

Ian J Donaldson, Berthold Göttgens Genome Biology 2006, 7:R52 (29 June 2006)

The genome-wide identification of conserved candidate transcription-factor binding sites that have evolved since the human-chimpanzee divergence supports the notion that changes in transcriptional regulation have contributed to the recent human evolution.

Methodology article   Open Access Highly Accessed

Combining evidence, biomedical literature and statistical dependence: new insights for functional annotation of gene sets

Marc Aubry, Annabelle Monnier, Celine Chicault, Marie de Tayrac, Marie-Dominique Galibert, Anita Burgun, Jean Mosser BMC Bioinformatics 2006, 7:241 (4 May 2006)

Methodology article   Open Access

Gene functional similarity search tool (GFSST)

Peisen Zhang, Jinghui Zhang, Huitao Sheng, James J Russo, Brian Osborne, Kenneth Buetow BMC Bioinformatics 2006, 7:135 (14 March 2006)

Method   Open Access

Large-scale gene discovery in the pea aphid Acyrthosiphon pisum (Hemiptera)

Beatriz Sabater-Muñoz, Fabrice Legeai, Claude Rispe, Joël Bonhomme, Peter Dearden, Carole Dossat, Aymeric Duclert, Jean-Pierre Gauthier, Danièle Ducray, Wayne Hunter, Phat Dang, Srini Kambhampati, David Martinez-Torres, Teresa Cortes, Andrès Moya, Atsushi Nakabachi, Cathy Philippe, Nathalie Prunier-Leterme, Yvan Rahbé, Jean-Christophe Simon, David L Stern, Patrick Wincker, Denis Tagu Genome Biology 2006, 7:R21 (10 March 2006)

A large-scale sequencing analysis of the Hemiptera Acyrthosiphon pisumexpressed sequence tags corresponding to about 12,000 unique transcripts is described, along with an in silico profiling analysis that identifies 135 aphid tissue-specific transcripts.

Database   Open Access

The Gene Set Builder: collation, curation, and distribution of sets of genes

Dimas Yusuf, Jonathan S Lim, Wyeth W Wasserman BMC Bioinformatics 2005, 6:305 (21 December 2005)

Methodology article   Open Access

Theme discovery from gene lists for identification and viewing of multiple functional groups

Petri Pehkonen, Garry Wong, Petri Törönen BMC Bioinformatics 2005, 6:162 (29 June 2005)